-
The National Parkinson’s Project: A Historic Opportunity to Address an Urgent, Growing Need
December 16, 2024
… nature, Parkinson’s research is currently spread across multiple federal agencies including the National Institutes … cost savings for patients and families, public health systems and the federal government. Together with other …
-
Validation of USP30 as a Therapeutic Target for Parkinson's Disease Modification
… USP30 is a newly discovered protein that regulates the clearance of poorly functioning mitochondria by modifying … Paul Thompson, PhD …
-
The role of nociceptin/orphanin FQ in regulation of motor behavior and induction of parkinsonism
… and attenuated akinesia and catalepsy induced by systemic haloperidol injection. On the basis of these … provide novel information on the behavioral profile of a systemically active NOP receptor antagonist in pre-clinical …
-
LRRK2 and Vitamin D3 Metabolism
… is to examine the role of LRRK2 in the regulation of systemic and local vitamin D3 metabolism and vitamin … We will decipher the role of LRRK2 in the regulation of systemic and local vitamin D3 levels and understand how …
-
Quantifying Spatiotemporal Gait Parameters with HoloLens in Healthy Adults and People with Parkinson’s Disease: Test-Retest Reliability, Concurrent Validity, and Face Validity
June 8, 2020
… validated markerless reference motion-registration system. We comprehensively evaluated HoloLens 1 for … over repetitions) and concurrent validity (i.e., between-systems agreement), using the intraclass correlation … limits of agreement. Test-retest reliability and between-systems agreement were excellent for walking speed (ICC ≥ …
-
Discovery of Translational Pharmacodynamic Biomarkers and Biomarkers of Endo-lysosomal Pathway Pathology by Biased & Unbiased Lipidomics and Metabolomics
… Study Rationale: The endolysosomal system within living cells is comprised of small, … that improve the impaired function of the endolysosomal system and benefit PD patients. Biomarkers (or indicators) …