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Increasing the Sensitivity of LRRK2 Assays: Development of Proximity Ligation Assays for LRRK2
… detection of signaling events within cells. We will develop multiple probes for LRRK2 kinase activity and several …
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Laboratory Phenotyping of Parkinson Disease Subjects Using a Multiplex Approach
… simultaneous analysis of several different markers (called multiplexing) - all from a single sample specimen (rather than multiple individual ones tested in parallel) – and thereby … aim to pursue the development of a further advanced multiplex assay for PD by converting existing and newly …
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The Michael J. Fox Foundation’s Strategy to Generate, Characterize, and Distribute Preclinical Alpha-Synuclein Research Tools for Molecular Biology
November 12, 2016
… launched alpha-synuclein protein library, which contains multiple versions of recombinant alpha-synuclein proteins …
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FDA Reviewing New Treatment for “Off” Episodes
December 20, 2019
… and the apomorphine sublingual film. It’s important to have multiple treatment options as patients may experience …
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Association of caffeine and related analytes with resistance to Parkinson’s disease among LRRK2 mutation carriers: a metabolomic study
August 5, 2020
… study site cohort, and sex, with p value corrections for multiple comparisons. Results: Plasma caffeine …
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Development of a Small Interfering RNA that Reduces Production of Alpha-synuclein in Parkinson's Disease
… of alpha-synuclein accumulation has been shown in multiple preclinical models to positively affect PD …
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