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Estimating Neuroprotective Effects of Nigral AAV-NRTN Using Selective Reaction Monitoring to Quantitatively Measure p-erk1/2 Signaling Strength in Nigral DA Neurons
… sites identified in both phases of the project included multiple phosphosites on MBP, CAMK2B, MAP1A, CRMP2/DPYSL2, … in an antibody-independent manner and interrogation of multiple signaling pathways in an unbiased …
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The Michael J. Fox Foundation for Parkinson’s Research Adopts Open Access Publication Policy
March 2, 2020
… transparency and scientific collaboration to accelerate the development of new treatments, The Michael J. Fox Foundation … its publication policy is the latest expression of MJFF’s commitment to collaboration, transparency and patient … short history. The Foundation has established multiple pre-competitive consortia for data-sharing and scientific …
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Analysis of Adhesion and Chemotactic Factor Expression Possibly Involved in T Cell Brain Extravasation in Parkinson's Disease: A Human Postmortem Analysis
… has been identified in patients with Parkinson's disease and implicated in neurodegeneration in pre-clinical models. … candidates in a pre-clinical model of the disease. To compare our experimental data with the real pathology, we … Gene expression level of candidates will be assessed and compared on the one hand, between affected and non-affected …
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Developing Progression Markers of Parkinson’s Disease with Multimodal Structural MRI of Substantia Nigra and Locus Coeruleus
… and again 16 months later. The MRI scans will include multiple “pulse sequences” or programs that acquire images …
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Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
February 4, 2015
… treatment for Parkinson's disease. However, there is no clinical validation as yet, and the safety implications of targeting LRRK2 kinase activity are not well understood. We evaluated the potential safety risks by comparing human and mouse LRRK2 mRNA tissue expression, by …
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Diurnal and Intersubject Variability of Cerebrospinal Fluid Biomarkers in Parkinson’s Disease and Healthy Volunteers
June 17, 2012
… may reflect a gradient effect by frequent CSF sampling at multiple time points over one day. Additionally, it will be …