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The role of nociceptin/orphanin FQ in regulation of motor behavior and induction of parkinsonism
… and attenuated akinesia and catalepsy induced by systemic haloperidol injection. On the basis of these … provide novel information on the behavioral profile of a systemically active NOP receptor antagonist in pre-clinical …
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LRRK2 and Vitamin D3 Metabolism
… is to examine the role of LRRK2 in the regulation of systemic and local vitamin D3 metabolism and vitamin … We will decipher the role of LRRK2 in the regulation of systemic and local vitamin D3 levels and understand how …
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Quantifying Spatiotemporal Gait Parameters with HoloLens in Healthy Adults and People with Parkinson’s Disease: Test-Retest Reliability, Concurrent Validity, and Face Validity
June 8, 2020
… validated markerless reference motion-registration system. We comprehensively evaluated HoloLens 1 for … over repetitions) and concurrent validity (i.e., between-systems agreement), using the intraclass correlation … limits of agreement. Test-retest reliability and between-systems agreement were excellent for walking speed (ICC ≥ …
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Discovery of Translational Pharmacodynamic Biomarkers and Biomarkers of Endo-lysosomal Pathway Pathology by Biased & Unbiased Lipidomics and Metabolomics
… Study Rationale: The endolysosomal system within living cells is comprised of small, … that improve the impaired function of the endolysosomal system and benefit PD patients. Biomarkers (or indicators) …
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Senate Votes Against Health Care Reform
July 28, 2017
… rejected a bill to reform our health care and insurance systems. This was the last of three proposals the Senate … members on both sides of the aisle to create a health care system that meets the needs of people with Parkinson’s and …
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The Nur77/RXR Transcriptional Complex as a New Target in L-Dopa-induced Dyskinesia Treatment
… (AIMs) rating scale. To investigate the role of RXR, systemic administrations of synthetic RXR agonists in … RXR may represent a selective target for the brain dopamine system with limited effects in the periphery. Anticipated … models (gene rescue), using a virally driven gene delivery system, exacerbated dyskinesia. This transcription factor is …