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Cutaneous Alpha-Synuclein Deposition — A Biomarker in Parkinson’s Disease
… alpha-synuclein deposition in the peripheral nervous system. Because PD has prominent manifestations in the autonomic system (which controls visceral functions like digestion, …
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The delta-specific opioid glycopeptide BBI-11008: CNS penetration and behavioral analysis in a preclinical model of levodopa-induced dyskinesia
December 18, 2020
… showed penetration of the blood-brain barrier (BBB) after systemic administration to rats, as well as profound central … it reduced the levodopa-induced locomotor AIMs by 50% after systemic injection. The N -methyl-D-aspartate receptor …
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Enhancing Access to Meaningful Data: Nebraska Parkinson’s Disease Registry
… (NPDR) will roll out a new electronic data collection system, enforce state statutes requiring that physicians … of Parkinson’s disease: Support of the NPDR electronic system implementation, operations and maintenance will …
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Examining the Mechanisms of Mitochondrial Damage Control by PINK1 and Parkin
… in PD. We already discovered one natural brake on the system, called Rubicon. By blocking Rubicon, we found we can make the system run better in cells, even when PINK1 and Parkin are …
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Patrick Flood, PhD
… mechanisms of inflammation within the Central Nervous System, as well as the role of the immune system in cancer resistance. …
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The Role of Subclinical Rejection in Graft-mediated Dyskinesias
… to test whether activation of the brain's immune system following withdrawal of immunosuppression results in … allow us explore whether activation of the brain's immune system plays a role in producing the negative side-effects …