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Gut Inflammation and Microbial Imbalance in Parkinson’s Disease
… environment can affect the activity of the nervous system, and inflammation in the gut could contribute to the … individuals, with and without PD, collected as part of the Systemic Synuclein Sampling study (S4). Samples of colon …
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New Study Looks at Gait Dysfunction and Falls in Parkinson’s
October 13, 2014
… play in ambulation issues. Changes in the acetylcholine system have been implicated in Parkinson’s-associated … will focus their efforts on understanding the acetylcholine system in more detail, parsing out its effect on falls and …
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Prothena Alpha-synuclein Antibody Completes Phase I and Readies for Next Step
November 10, 2016
… announced, too, that the drug gets into the central nervous system well and reduces levels of alpha-synuclein in blood … anti-alpha-synuclein antibody — the body’s natural immune system fighters — is one way researchers aim to stop the …
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Amy Rubinstein, PhD
… of dopamine-producing neurons. Molecules identified in this system could form the basis for developing new PD drugs. Dr. … Rubinstein studied the development of the zebrafish nervous system, under the direction of Dr. Marnie Halpern. In July …
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Investigating the Role of Immune Cell Exhaustion (ICE) and Biological Immune Aging (BIA) in PD Risk and PD Heterogeneity
… We aim to understand if and how the aging immune system plays a role in both causing Parkinson’s disease and … uncover novel treatment strategies that target the immune system to slow or prevent disease progression in specific …
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T-Cell Receptors Changes as a Biomarker of Parkinson's Disease
… can be mirrored by alterations in the peripheral immune system, we will study white blood cell (T-cell) receptor … to develop a blood test to profile markers of the immune system that correlate with clinical stages of PD. In … TCR changes that change as disease progresses, these immune system markers will serve as a biomarker for PD diagnosis …