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Multi-center Study of EEG Biomarkers for Alpha-synucleinopathy Diagnosis and Prognosis Decision Support Tools Using Machine Learning
… Sleep Disorders …
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Integrated Analysis of Alpha-synuclein in the North American Prodromal Synucleinopathy (NAPS) Cohort
… Study Rationale: REM sleep behavior disorder is well recognized as a prodromal … based on detailed characterization of REM sleep behavior disorder in a prodromal patient population. … in a seed amplification assay in individuals with REM sleep behavior disorder, along with co-pathology markers in …
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Can the electrocardiogram be used to identify pre-motor Parkinson's Disease
… 47 patients diagnosed with pure RBD who underwent all night sleep recordings at the Stanford Sleep Clinic between 2000 and 2008. Age-and gender matched … Sleep Disorders …
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Prospective Validation of Risk Markers for the Development of Parkinson’s Disease
… markers and symptoms are discussed to antedate PD – i.e. sleep problems (specifically rem sleep behaviour disorder, RBD), autonomic dysfunction (like … Sleep Disorders …
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Evaluation of a Specific DAT Inhibitor in Pre-clinical Models of Parkinson's Disease
… use induces complications such as movement disorders, sleep disturbances (nightmares, nocturnal confusion), and … thereby also reducing side effects such as movement and sleep disorders. Project Description: Pre-clinical models … PD is a multi-symptom disease with deficits in motor, sleep, cognitive, and other systems, we propose to establish …
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Relationship between REM Behavior Disorder and Freezing of Gait in Parkinson's Disease
… Objective/Rationale: Many people with REM sleep behavior disorder (RBD), a disease associated with disturbance of sleep, eventually develop Parkinson’s disease. Dysfunction … people with RBD alone; people with PD who have severe FOG problems; people with PD who do not have FOG, and control …
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