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Colin Kelly Combs, PhD
… Combs’ laboratory focuses on understanding how the immune system contributes to brain changes during chronic …
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Douglas G. Manuel, MD, MSc
… research interests include population health, health care systems and primary care. Researchers at the Ottawa Hospital …
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Jackson G. Schumacher, BS
… efforts focused on Parkinson’s genetics, systems biology, and early-stage therapeutic discovery. …
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IL-13Ra1 and Neuroinflammatory Damage in the MPTP Pre-Clinical Model of PD
… may represent novel therapeutic targets for PD. The “IL-13 system” is an attractive drug target due to its role in … here will help us determine whether targeting the “IL-13 system” represents a novel strategy to treat PD. Next Steps …
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Responsive, Closed-Loop Approach to Treat Freezing of Gait in Parkinson’s Disease
… that may lead to freezing of gait in order to develop a DBS system to target this symptom. Hypothesis: We posit that we can develop a “smart” DBS system that will monitor the GPi and the PPN (and the …
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Functional Evaluation of Alpha-synuclein Dosage Effects in CRISPR‐edited SNCA Model
… cell lines to address variability of the cell model system, to characterize potential off-target effects of … or related alpha-synucleinopathies. Our unique cell model system of different alpha-synuclein gene copies at the …
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