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Antibody Testing in Postmortem Human Brain
… human brain samples presently held at the Banner Sun Health Research Institute in Sun City, AZ and the University …
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PD Pre-clinical Model Repository
… easily monitored. The JAX repository carefully monitors the health status and the genetic composition of the mice it … to investigate how genetic factors interact with environmental factors. Anticipated Outcome: We hope that this …
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Mechanisms of Parkin Recruitment and Mitophagy
… Parkin is thought to be required for the maintenance of healthy mitochondria, critical subcellular organelles that … required for Parkin to work properly. Objectives for Supplemental Investigation: The work that we will now do stems … Parkin activity and its involvement in maintenance of the health and function of mitochondria. We will also focus on …
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The Influence of Bacterial Amyloid on Alpha-synuclein Misfolding in a Pre-clinical Model Supplement
… animals receiving control bacteria. Objectives for Supplemental Investigation: We will carry out further … of the bacteria residing in our intestines for human health and disease. The results will be valuable for …
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Disruption of Pathological Protein-protein Interactions in Alpha-synuclein
… is to conduct pilot screens with the National Institutes of Health Clinical Compound library and the Library of …
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Cognitive-driven Activities of Daily Living Impairment as a Predictor for Parkinson's Disease Dementia
… contributions to ADL impairment can aid researchers and health care professionals in reaching a definite PDD …