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PET Tracer to Support Trials of Drugs Inhibiting Neuroinflammation via the NLRP3 Inflammasome
… diseases such as Alzheimer’s, motor neuron disease, and multiple system atrophy. Next Steps for Development: Once the PET tracer has …
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Maximizing the Sensitivity of Seed Amplification Assays Used to Detect Alpha-synuclein Aggregates
… but distinguishable protein aggregates involved in PD and multiple systems atrophy (MSA). Impact on Diagnosis/Treatment of Parkinson’s …
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Using the Chemical Modification of Alpha-synuclein to Define Disease State and Facilitate Patient Stratification in Parkinson’s Disease
… Study Rationale: Novel disease-modifying treatments for Parkinson’s disease (PD) are urgently needed as the prevalence … of Parkinson’s disease: Next, we will further validate quantitative alpha-synuclein modification assays for …
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Episode 10: Understanding Genetics, Pathology, and Progression in Parkinson's Disease and Atypical Parkinsonian Syndromes with Huw Morris
March 5, 2024
… Syndromes, such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and dementia …
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Quantitative SAA for Measuring Disease Progression in Parkinson’s Disease from Plasma
… REM-sleep behavior disorder, dementia with Lewy bodies, and multiple system atrophy. Additionally, we will work toward making the assay …
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Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function
May 23, 2022
… such as dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Although the etiology of most …