Your search for “Multiple System Atrophy” returned 2622 results.
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Nigrostriatal Dopaminergic Degeneration and Alpha-synuclein Aggregation in Mice with Reduced TrkB Signaling
… which promote survival of neurons in the mammalian nervous system. We have generated a mouse mutant which expresses the …
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Specific Inhibition of Nucleation of Alpha-synuclein Aggregation As a Therapeutic Strategy
… is to identify this enzyme, using a powerful genetic model system, with the longer-term goal of seeing if inhibiting …
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Validation of VPS41, a protein involved in lysosomal trafficking, as a target for Parkinson disease therapy
… target to emerge was VPS41, believed to be involved in systems that breakdown abnormal proteins. Our goal is to …
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Testing of small molecules in an alpha-synuclein pre-clinical model of Parkinson’s disease
… molecular and cellular perturbations of the nigrostriatal system in response to alpha-synuclein and implementing the …
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Engineering Midbrain Dopamine Neurons by Forced Expression of a Novel Dopamine Cell Determinant in Pre-Clinical Model Embryonic Stem Cells
… Transcriptional Activity by the Ubiquitin Proteasome System Understanding how the different cells of the brain …
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Executive, ADL, and Cholinergic Functions in PD
… (in addition to drugs that act on the dopamine brain system) to improve cognitive functions and activities of …