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Characterization of LRRK2 Monoclonal Antibodies in Pre-clinical Brain Tissue
… A color signal is generated via an immunological detection system. Brain tissue will include (a) normal pre-clinical … express LRRK2 gives us clues to which neurotransmitter systems/brain circuitries rely on normal LRRK2 function. …
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Drug Rescue of PINK1 Kinase Activity - A New Therapeutic Modality For Treating PD
… unprecedented but we have solid evidence in simplified systems that we can increase the function of a …
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LRRK2 in Neuronal Architecture
… simple read-out of efficacy for future compound screening. systems Robust ‘etiologic’ are vital for, to develop novel …
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Generation of a Novel Recombinant Protein Activator of GPR88
… Anticipated Outcome : We plan to further improve the system we use to screen keys so that if needed, we can …
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AFFITOPE based immunotherapeutic strategies for Parkinson´s disease
… accumulations, so called Lewy bodies, in the nervous system. Alpha-synuclein is currently believed to be central …
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Exploring Serotonergic Cortical Targets for Treatment of Parkinson's Disease Using a Mathematical Disease Model
… modulation of the serotonergic and dopaminergic systems. After screening a large number of approved and …
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