… — to measure the amount and distribution of brain atrophy in both diseases, related to clinical severity. We …

… alpha-synuclein) via its effect on the Renin Angiotensin System in the brain, a system that is associated with cognition enhancement and … followed by other cellular and molecular analyses in multiple brain regions to understand how PNA5 alters …

… mechanism for LRRK2. This work will create a measurable system to detect the phosphorylation/ubiquitination of LRRK2 … cycle of LRRK2 modification. Project Goal: Cellular systems are ideal to study the molecular players in a … can be adapted to a multi-well format to enable testing of multiple regulators of LRRK2 phosphorylation at once. Study …

… Study Rationale: This study aims to compare the immune system of Parkinson's disease (PD) patients and their … clinical research efforts have implicated the immune system as a potential source of PD biomarker information. … the same environment. These samples will be evaluated for multiple inflammatory and immunological endpoints. We will …

… in Parkinson’s disease. Inflammation is an immune system response to injury or disease, but chronic … research. This initiative seeks to approach the issue from multiple angles, including:  Evaluating the prevalence of … that enhance survival of cell grafts in the nigrostriatal system; and Exploring immune status as a biomarker of …

… addresses this need by developing a unique human cellular system for the early identification and study of … investigator plans to grow skin fibroblasts derived from multiple Parkinson's patients and age-matched controls and …