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Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model
June 9, 2021
… Multiple mutations have been described in the human GBA1 … and inflammation were not observed in the nigrostriatal system of this model. In summary, the GBA1 D409V KI mouse …
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Richard Macko, MD
… based exercise strategies have potential to improve multiple physiological systems which determine disability in other condtions, …
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Caleb Webber, PhD
… may be best understood through the contribution of multiple genes to multiple disease-relevant processes. Thus, Dr. Webber does … and models of gene functional relationships that allow multiple pathways and processes to intersect. His gene …
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The Michael J. Fox Foundation for Parkinson’s Research Announces Study to Measure Parkinson’s Protein throughout Body
March 16, 2016
… Parkinson’s Research (MJFF) has launched the observational Systemic Synuclein Sampling Study (S4) to investigate the … research at the Institute for Neurodegenerative Disorders. “Multiple studies have demonstrated the significance of … biomarker, but none have measured alpha-synuclein levels in multiple biofluids and peripheral tissues in a single …
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Team Big B: How Honoring Brian Adam Turned 100 Miles into Impact
December 22, 2025
… of Big B. I watched Brian battle Parkinson’s disease and Multiple System Atrophy for years, and he faced the disease and the daily …
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Development of Nanobodies as Novel Tools to Characterize LRRK2 as a Potential Drug Target for Parkinson's Disease
… (accelerates chemical reactions) functions. Targeting the multiple enzymatic functions of LRRK2 represents a very … fragments derived from a special type of antibodies (immune system cells) present in camelids such as llamas. In recent …