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Screen for Novel Glucocerebrosidase-Interacting Parkinson's Genes
… characteristic Parkinson’s disease pathology in the nervous system, as well as for motor problems (such as difficulty … of when GBA leads to degeneration of neurons in the nervous system. We expect that our screen will identify novel genes … Parkinson’s disease. With this study we expect to identify multiple genes with previously unrecognized roles in …
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Global Efforts & Resources in Parkinson’s Research
… Disease The study, a collaborative effort between multiple nonprofit partner organizations and industry … Parkinson's Disease is Moving Towards a Biological Staging System Much like Alzeihmer's and Huntington's, Parkinson‘s disease is moving towards a biologic staging system, with a potentially transformational impact on …
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TGF-beta Signaling as Novel Therapeutic Treatment for Parkinson's Disease
… to Diagnosis/Treatment of Parkinson’s Disease: TGF-beta has multiple associations with Parkinson's disease as well as the nigrostriatal system. However, no direct causal relationship has been …
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A New Pharmaceutical Target for Mono and Add-on Therapy in Parkinson’s Disease
… Description: We have recently discovered multiple small molecules that are capable of inhibiting the … A novel medicine for PD not targeting the dopamine system of the brain could improve patient’s quality of life. …
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Comparing the Effectiveness of Two Imaging Methods for Monitoring the Progression of Parkinson’s Disease
… imaging methods can be used to monitor the brain’s dopamine systems and assess how dopamine-producing neurons are … study in which people with PD undergo repeated imaging at multiple time points. Such assessment could improve our …
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Using “Nanobodies” to Prevent Formation of Intracellular Alpha-synuclein Aggregates
… particular, we will inhibit proteasomes and lysosomes, two systems cells use to degrade damaged and worn-out … its penetration and distribution. Finally, we will use multiple techniques to assess whether protection of …