… Alberto Ascherio leads multiple NIH-funded projects involving both national and … Ascherio has developed the skills to efficiently manage the multiple steps of scientific research, from study design and … the past 25 years, he has direction the investigations of multiple sclerosis (MS), Parkinson’s disease (PD) and …

… to Diagnosis/Treatment of Parkinson’s Disease: TGF-beta has multiple associations with Parkinson's disease as well as the nigrostriatal system. However, no direct causal relationship has been …

… Description:              We have recently discovered multiple small molecules that are capable of inhibiting the …          A novel medicine for PD not targeting the dopamine system of the brain could improve patient’s quality of life. …

… imaging methods can be used to monitor the brain’s dopamine systems and assess how dopamine-producing neurons are … study in which people with PD undergo repeated imaging at multiple time points. Such assessment could improve our …

… particular, we will inhibit proteasomes and lysosomes, two systems cells use to degrade damaged and worn-out … its penetration and distribution. Finally, we will use multiple techniques to assess whether protection of …

…  We hypothesize that specific changes in the immune system play a role in the development and progression of PD … from individuals with varying forms of PD. We will then use multiple single-cell analytic techniques to catalog the …