… Objective/Rationale:  Multiple pieces of evidence converge on the notion that … model, and whether induction of this degradation system in vivo can be used to get rid of excess … in PD, is unknown. Project Description:  We will use a system of viral delivery, in which the gene of interest is …

… We aim to generate pre-clinical models that incorporate multiple genetic defects found in PD patients. In terms of … littermate controls. Characterization of the dopaminergic system and the neurobiological basis for this phenomenon is …

… the inflammatory response by modulating the immune system to alleviate the hostile environment associated with … to neuronal proteins and currently approved for use in multiple sclerosis, inhibit inflammation and neuronal death …

… state and re-establishing a functional dopaminergic system. Finally, some critical aspects of these neurons will … of disease-affected iDA neurons for studying in the dish multiple pathogenetic mechanisms of PD with relevant …

… (i.e., programmed). However, DBS programming often requires multiple clinic visits to test the large number of possible … DBS for Parkinson’s disease. The process of programming DBS systems takes numerous clinic visits, resulting in a long, …

… the neural networks that control an example of each system. Hypothesis:  Understanding the wiring diagrams that … we will study the celiac ganglion, which innervates multiple internal organs, including the esophagus, stomach, …