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Evaluating the Therapeutic Potential of the Systemic Antagonism of Dopamine Receptor D3
… for dopamine (DR), a substance produced by the nervous system, plays a pivotal role in the death of brain cells … if inhibiting the dopamine receptor in this more complex system still provides a therapeutic benefit. Our goal is to …
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The First Biological Staging System for Parkinson’s: A Research Accelerator for the Field
January 23, 2024
… think about the disease. The framework then describes a system for staging the disease that accounts for Parkinson’s … as the neuronal alpha-synuclein disease integrated staging system (NSD-ISS), is the first biological staging system for …
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Does Peripheral Immune Challenge Exacerbate LRRK2-Induced Neuronal Pathology?
… has recently also been highlighted as a mediator of immune system function. We believe that aberrant interactions … onset in PD. In this project we will determine how a systemic infection can influence neural dysfunction and …
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New Findings Add to Evidence of Immune System Role in Parkinson's Disease
June 22, 2017
… University revealed a possible link between the immune system -- the body's defense system against disease -- and alpha-synuclein , the sticky …
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Parkinson's and Inflammatory Bowel Diseases: Interaction in LRRK2 Transgenic Pre-clinical models
… suggest that LRRK2 is an important modulator in the immune system. Thus, it is important to determine if immune system alterations may play a role in LRRK2-PD and if …
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Parallel Reaction Monitoring within the Parkin Ubiquitin Ligase System
… of more than a dozen mitochondrial proteins. Using this system, we closely followed the ubiquitylation process and …