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Alpha-Synuclein Assay Standardization LEAPS
… blood, cerebrospinal fluid and saliva has been reported by multiple scientists using a variety of analytical … that have the necessary experience and expertise to assess multiple alpha-synuclein research assays for consistency of … who developed the assay to be tested. Each team consists of multiple laboratories that will compare the performance of …
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Jeffrey A. Johnson, PhD
… ARE-driven genes. This common pool of genes includes multiple detoxification enzymes and antioxidant genes, which … with neuronal cell death during the pathogenesis of multiple chronic neurodegenerative diseases including … of the Nrf2-ARE pathway is being evaluated through multiple techniques including: 1) genomic and proteomic …
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Characterization, Optimization and Validation of a Preformed Fibril Pre-clinical Model of Parkinson's Disease
… platform will allow for evaluation of treatment effects on multiple brain regions simultaneously to address non-motor … wide spread use and thereby provide a platform for multiple investigators to use the same platform from which …
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Determining the Level of LRRK2 Inhibition Required for Therapeutic Efficacy
… has yet to be determined. This study will examine multiple levels of target engagement in a model of … linked to LRRK2 inhibition). Next, we will determine multiple doses of PFE360 that produce differing levels of …
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Kevin J. Tomaselli, PhD
… first-in-class, oral small molecule currently in multiple Phase 2 clinical trials in hematologic and solid … focused on apoptosis, or programmed cell death, across multiple therapeutic areas, including cancer, CNS, …
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Carole Ho
… tenure at Genentech, she led the successful development of multiple therapeutics that advanced to Phase III trials or were approved, including ocrelizumab for multiple sclerosis, lampalizumab for age-related macular …