-
Determine the Structure of LRRK2 Protein
… The purpose of this consortium is to bring together multiple laboratories, technologies and approaches to obtain … quantities to study biochemically. We have developed new systems for making this protein in cells in the laboratory, …
-
MJFF Issues Grant to Expand, Leverage Important Parkinson’s Dataset
May 9, 2025
… data that helps with examining the role of the immune system in PD, whole genome sequences to facilitate genetic … datasets. This grant builds upon the successes of multiple data collection and sharing efforts, moving us …
-
Functional Analysis of LRRK2 Phosphorylation in Human Dopaminergic Neurodegeneration
… First, we will quantify LRRK2 phosphorylation at multiple sites on mDA neurons. mDA neurons with typical or … This project will lead to a better understanding of how multiple LRRK2 phosphorylation sites are regulated within …
-
Allogeneic Bone marrow-derived Mesenchymal Stem Cells as a Disease-modifying Therapy for Idiopathic Parkinson’s Disease: Phase 2a Double-Blind, Randomized Controlled Trial
… neuroinflammation in PD. Hypothesis: We hypothesize that multiple intravenous infusions of mesenchymal stem cells … Next Steps for Development: This trial aims to prove that multiple infusions of mesenchymal stem cells are a safe and …
-
Preclinical Efficacy and Biomarker Development for a Clinical Stage Inhibitor of Lipid Metabolism in Parkinson’s Disease
… that inhibits SCD. In this study, we will test YTX-7739 in multiple preclinical models that differ in how … reveal how YTX-7739 affects alpha-synuclein toxicity in multiple brain cell types and how people with PD may best …
-
Evaluation of Digital Mobility Data to Identify Individuals at Risk of Developing Parkinson’s Disease
… technology provides accurate, sensitive assessment of multiple, disparate mobility functions, both in controlled … technology, which is capable of accurately capturing multiple mobility functions. Development of these …