… in general unfolds at a snail’s pace, central nervous system (CNS) drug development moves at the clip of a banana …

… for dopamine (DR), a substance produced by the nervous system, plays a pivotal role in the death of brain cells … if inhibiting the dopamine receptor in this more complex system still provides a therapeutic benefit. Our goal is to …

… symptom progression. We propose using the samples from the Systemic Synuclein Sampling Study (S4) to identify … levels in different tissues and to responses of biologic systems in PD via metabolomics. Impact on …

… think about the disease.   The framework then describes a system for staging the disease that accounts for Parkinson’s … as the neuronal alpha-synuclein disease integrated staging system (NSD-ISS), is the first biological staging system for PD. With it, biopharma companies can more …

… is tightly controlled by specific protein degradation systems whose activity can be disrupted in PD. The goal of …