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Parkinson's and Inflammatory Bowel Diseases: Interaction in LRRK2 Transgenic Pre-clinical models
… suggest that LRRK2 is an important modulator in the immune system. Thus, it is important to determine if immune system alterations may play a role in LRRK2-PD and if …
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June Third Thursdays Webinar Immune's System Role in Parkinson's Transcript
… June 2019_Immune System Webinar July 2018 Podcast_transcript.pdf …
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Investigation of Neuroinflammation in LRRK2 Mutation Carriers Using Positron Emission Tomography
… with a downstream selective impact on the dopaminergic system. It is thus reasonable to surmise that the primary, … related to the link between LRRK2 function and the immune system. Project Description: The first goal …
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LRRK2 Regulates Host Response to Microbial Infections
… this, to explore a function for LRRK2 in the immune system. Several laboratories including ours determined that … hope to have shown that LRRK2 has a function in the immune system, which will undoubtedly inform efforts to develop …
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Regulation of Nurr1 Nuclear Receptor Transcriptional Activity by the Ubiquitin Proteasome System
… is tightly controlled by specific protein degradation systems whose activity can be disrupted in PD. The goal of …
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Regulated GDNF Gene Therapy: A Novel Regulatory System Based on Protein Degradation
… grant: Regulated GDNF Gene Therapy: a Novel Regulatory System Based on Protein Degradation Promising Outcomes of … step towards development of a new regulatable gene therapy system for trophic factors to combat Parkinson’s disease. …