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The Michael J. Fox Foundation Funds $2 Million to Solve Midbrain System Mysteries
June 23, 2004
… signals that produce and maintain the midbrain dopaminergic system that degenerates in Parkinson’s disease. The awards … brain circuitry network. Understanding how the dopamine system develops and functions will shed light on the causes … Patterning and Maintenance of Midbrain Dopaminergic Systems in the Normal and Parkinsonian Brain initiative: …
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Identification of Axon Guidance Molecules Relevant to the Midbrain Dopaminergic System
… In Parkinson's patients a substantial number of dopaminergic neurons necessary for proper motor …
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The Michael J. Fox Foundation to Fund $2 Million for Study of Midbrain System
October 22, 2003
… suggests that greater insight into the entire dopaminergic system, including its development, will increase … the local environment in the midbrain and the dopaminergic system we are trying to repair is crucial to refining new … executive director. “Understanding the functioning of this system within the brain is essential to rapid development of …
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Development of a Cellular System to Screen for Small Molecules that Upregulate the hVMAT2 Promoter Activity
… Objective/Rationale: We will develop an essential cellular system as a platform for future high throughput screen (HTS) … development. Project Description: To establish the cellular system, we will genetically engineer SH-SY5Y cells to link … of Parkinson’s Disease: Establishment of this cellular system will facilitate HTS for small molecules that …
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Exploring a Novel Neurotrophic Factor to Protect the Nigrostriatal Dopaminergic System and Alleviate Motor Deficits
… studies to assess the integrity of dopaminergic system. The combined approaches at both structural and …