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Regulation of Nurr1 Nuclear Receptor Transcriptional Activity by the Ubiquitin Proteasome System
… is tightly controlled by specific protein degradation systems whose activity can be disrupted in PD. The goal of …
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The Michael J. Fox Foundation Funds $2 Million to Solve Midbrain System Mysteries
June 23, 2004
… signals that produce and maintain the midbrain dopaminergic system that degenerates in Parkinson’s disease. The awards … brain circuitry network. Understanding how the dopamine system develops and functions will shed light on the causes … Patterning and Maintenance of Midbrain Dopaminergic Systems in the Normal and Parkinsonian Brain initiative: …
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The Michael J. Fox Foundation to Fund $2 Million for Study of Midbrain System
October 22, 2003
… suggests that greater insight into the entire dopaminergic system, including its development, will increase … the local environment in the midbrain and the dopaminergic system we are trying to repair is crucial to refining new … executive director. “Understanding the functioning of this system within the brain is essential to rapid development of …
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Dissecting Non-canonical Basal Ganglia Output Circuitry Modulating Movement
… Study Rationale: Multiple brain structures work together to coordinate … system biology …