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Research Paper Adds Clinical Anchors to Proposed Parkinson’s Staging System
October 11, 2024
… the Neuronal alpha-Synuclein Disease Integrated Staging System (NSD-ISS) . The FDA acknowledged the potential of … fine-tune these definitions and improve the staging system even further. The NSD-ISS framework, bolstered by …
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Development of a Cellular System to Screen for Small Molecules that Upregulate the hVMAT2 Promoter Activity
… Objective/Rationale: We will develop an essential cellular system as a platform for future high throughput screen (HTS) … development. Project Description: To establish the cellular system, we will genetically engineer SH-SY5Y cells to link …
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The Michael J. Fox Foundation to Fund $2 Million for Study of Midbrain System
October 22, 2003
… suggests that greater insight into the entire dopaminergic system, including its development, will increase … Patterning, and Maintenance of Midbrain Dopaminergic Systems In the Normal and Parkinsonian Brain is one element …
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The Four Horsemen of G2019S
… G2019S variant of LRRK2 are abnormally sensitive to immune system molecules that naturally increase in the body with … … Inflammation … California … LRRK2 … LRRK2 in the Immune System … Theo D. Palmer, PhD …
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Studying DNA Methylation in Parkinson’s Disease Using the Systemic Synuclein Sampling Study
… symptom progression. We propose using the samples from the Systemic Synuclein Sampling Study (S4) to identify … levels in different tissues and to responses of biologic systems in PD via metabolomics. Impact on …