… underlying frontotemporal dementia and studying whether multiple mechanisms are associated with the different …

… previously led efforts at Codexis, where his team advanced multiple therapeutic enzyme candidates—several with FDA …

… association studies (PheWAS) in large biobanks across multiple human populations, as demonstrated in his recent …

… antennas to receive signals. Inside the cell, a recycling system helps maintain these antennas by removing old or … parts and replacing them with new ones. If either of these systems fails, brain cells cannot process signals correctly … disease. Our study aims to uncover how these two systems normally work together and what goes wrong in …

… that accumulate in cells of the central nervous system. In healthy cells, protein misfolding and aggregation … or reversed by various protein quality control (PQC) systems. However, we lack a complete understanding of these systems, which hinders our ability to develop therapies for …

… Objective/Rationale: The heart, particularly the conduction system, is influenced by the parasympathetic and sympathetic nervous systems. Recently, early-occurring Parkinson’s … cardiac pathology fits into the neuropathological staging system for the brain published by our Frankfurt group in …