… association studies (PheWAS) in large biobanks across multiple human populations, as demonstrated in his recent …

… that accumulate in cells of the central nervous system. In healthy cells, protein misfolding and aggregation … or reversed by various protein quality control (PQC) systems. However, we lack a complete understanding of these systems, which hinders our ability to develop therapies for …

… Objective/Rationale: The heart, particularly the conduction system, is influenced by the parasympathetic and sympathetic nervous systems. Recently, early-occurring Parkinson’s … cardiac pathology fits into the neuropathological staging system for the brain published by our Frankfurt group in …

… The Brio Neurostimulation System consists of a pacemaker-like device implanted in the … disease and essential tremor. The Brio Neurostimulation System from St. Jude Medical works in a similar way as the … device: Medtronic’s Activa Deep Brain Stimulation Therapy System, approved in 1997 for tremor and in 2002 for …

… death of nerves within the gut (i.e., the enteric nervous system), driven by accumulation of toxic forms of the … symptoms. This program seeks to develop a new experimental system that accurately replicates Parkinson’s disease biology in enteric nervous system cell cultures. The investigators will use it to …

… Objective/Rationale: The glutamate, serotonin and adenosine systems are interesting targets for pharmacological … disease. However, interventions addressed at single systems have so far produced limited results. Indeed, the … are complex and affect the function of several brain systems. In this project we intend to counteract dyskinesia …