… killer (NK) cells play a protective role on the nervous system in Parkinson’s disease. We evaluated the role of NK … cells in synuclein-related diseases that affect the nervous system. Our study provided evidence of potential usefulness … demonstrated the protective role of NK cells on the nervous system in a preclinical model of Parkinson’s. The next steps …

… GTPase activation in vitro. Final Outcome After testing multiple sources of LRRK2, we found that only LRRK2 isolated … a robust assay for GDP production by LRRK2. We identified multiple hit compounds that reproducibly inhibited GDP …

… Objective/Rationale: Parkinson’s disease has multiple genetic and environmental causes. As a result, … or pharmacological tools was found to be protective in multiple animal models of Parkinson’s disease, stroke, …

… target for PD research. LRRK-2 is a large protein with multiple functional domains, including a protein kinase … has well-recognized expertise in this approach, having multiple ongoing kinase inhibitor programs in several …

… is present alone (as a monomer) or in a large complex with multiple LRRK2 molecules, and then directly measure its … known as size-exclusion chromatography. We will then assess multiple aspects of LRRK2 kinase activity simultaneously; …

… disorders—which include Parkinson’s, Alzheimer’s, ALS, and multiple sclerosis, and others—have many features and … the three-day Neurodegenerative Drug Development Summit. Multiple companies that have received support from MJFF are …