… Nature Protocols, and Science. He has received multiple awards, including the Ernst-Reuter Award, the NCL …

… from discovery through development and authorization across multiple therapeutic areas and modalities. He leverages his …

… GTPase activation in vitro. Final Outcome After testing multiple sources of LRRK2, we found that only LRRK2 isolated … a robust assay for GDP production by LRRK2. We identified multiple hit compounds that reproducibly inhibited GDP …

… Objective/Rationale: Parkinson’s disease has multiple genetic and environmental causes. As a result, … or pharmacological tools was found to be protective in multiple animal models of Parkinson’s disease, stroke, …

… target for PD research. LRRK-2 is a large protein with multiple functional domains, including a protein kinase … has well-recognized expertise in this approach, having multiple ongoing kinase inhibitor programs in several …

… is present alone (as a monomer) or in a large complex with multiple LRRK2 molecules, and then directly measure its … known as size-exclusion chromatography. We will then assess multiple aspects of LRRK2 kinase activity simultaneously; …