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Does Peripheral Immune Challenge Exacerbate LRRK2-Induced Neuronal Pathology?
… has recently also been highlighted as a mediator of immune system function. We believe that aberrant interactions between mutant LRRK2 and the immune system may modify disease onset in PD. In this project we will determine how a systemic infection can influence neural dysfunction and …
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Parkinson's and Inflammatory Bowel Diseases: Interaction in LRRK2 Transgenic Pre-clinical models
… suggest that LRRK2 is an important modulator in the immune system. Thus, it is important to determine if immune system alterations may play a role in LRRK2-PD and if … models exhibit functional alterations in the immune system that elucidate overlap in pathogenic mechanisms …
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Axonopathy induced by overexpression of human -synuclein in the rat nigrostriatal dopamine system
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Identification and Characterization of Compounds that Regulate the Activity of the LRRK2 System
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Investigation of Neuroinflammation in LRRK2 Mutation Carriers Using Positron Emission Tomography
… with a downstream selective impact on the dopaminergic system. It is thus reasonable to surmise that the primary, … related to the link between LRRK2 function and the immune system. Project Description: The first goal … Most importantly, if treatment targeting the immune system is administered early in a subject-at-risk life, it …
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Proteomic analysis of accumulated proteins in dopaminergic neurons using a pre-clinical model ofubiquitin-proteasome system dysfunction
… that degrades them. Failure of this protein degradation system in dopamine neurons is believed to contribute to the …