-
Assessment of the Novel Neuronal Synuclein Disease Staging System in Stratifying Dementia with Lewy Bodies Patients
… of "the neuronal synuclein disease (NSD) integrated staging system,” originally designed for PD, in people with … translational research on DLB. We will use the NSD staging system to categorize patients within the E-DLB that have … of Parkinson’s disease: Application of the NSD staging system in DLB should reduce diagnostic variability and …
-
Axonopathy induced by overexpression of human -synuclein in the rat nigrostriatal dopamine system
-
Identification and Characterization of Compounds that Regulate the Activity of the LRRK2 System
-
Does Peripheral Immune Challenge Exacerbate LRRK2-Induced Neuronal Pathology?
… has recently also been highlighted as a mediator of immune system function. We believe that aberrant interactions between mutant LRRK2 and the immune system may modify disease onset in PD. In this project we will determine how a systemic infection can influence neural dysfunction and …
-
Parkinson's and Inflammatory Bowel Diseases: Interaction in LRRK2 Transgenic Pre-clinical models
… suggest that LRRK2 is an important modulator in the immune system. Thus, it is important to determine if immune system alterations may play a role in LRRK2-PD and if … models exhibit functional alterations in the immune system that elucidate overlap in pathogenic mechanisms …
-
Proteomic analysis of accumulated proteins in dopaminergic neurons using a pre-clinical model ofubiquitin-proteasome system dysfunction
… that degrades them. Failure of this protein degradation system in dopamine neurons is believed to contribute to the …