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Axonopathy induced by overexpression of human -synuclein in the rat nigrostriatal dopamine system
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Identification and Characterization of Compounds that Regulate the Activity of the LRRK2 System
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Does Peripheral Immune Challenge Exacerbate LRRK2-Induced Neuronal Pathology?
… has recently also been highlighted as a mediator of immune system function. We believe that aberrant interactions between mutant LRRK2 and the immune system may modify disease onset in PD. In this project we will determine how a systemic infection can influence neural dysfunction and …
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Parkinson's and Inflammatory Bowel Diseases: Interaction in LRRK2 Transgenic Pre-clinical models
… suggest that LRRK2 is an important modulator in the immune system. Thus, it is important to determine if immune system alterations may play a role in LRRK2-PD and if … models exhibit functional alterations in the immune system that elucidate overlap in pathogenic mechanisms …
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Proteomic analysis of accumulated proteins in dopaminergic neurons using a pre-clinical model ofubiquitin-proteasome system dysfunction
… that degrades them. Failure of this protein degradation system in dopamine neurons is believed to contribute to the …
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Using a Systems-based Approach to Study the Molecular Processes Underlying Parkinson’s Disease: The Foundational Data Initiative
… disease networks. Hypothesis: We hypothesize that systems-based approaches, combined with complex genetics, … of potential therapeutics against identified targets. This system can also be used to test whether an intervention is …