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Dissecting Non-canonical Basal Ganglia Output Circuitry Modulating Movement
… Study Rationale: Multiple brain structures work together to coordinate … system biology …
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Toward an Atlas of Endolysosomal System Dysfunction with PD-associated Channels/Transporters
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Development of a Cellular System to Screen for Small Molecules that Upregulate the hVMAT2 Promoter Activity
… Objective/Rationale: We will develop an essential cellular system as a platform for future high throughput screen (HTS) … development. Project Description: To establish the cellular system, we will genetically engineer SH-SY5Y cells to link … of Parkinson’s Disease: Establishment of this cellular system will facilitate HTS for small molecules that …
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Exploring a Novel Neurotrophic Factor to Protect the Nigrostriatal Dopaminergic System and Alleviate Motor Deficits
… studies to assess the integrity of dopaminergic system. The combined approaches at both structural and …
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Does Peripheral Immune Challenge Exacerbate LRRK2-Induced Neuronal Pathology?
… has recently also been highlighted as a mediator of immune system function. We believe that aberrant interactions between mutant LRRK2 and the immune system may modify disease onset in PD. In this project we will determine how a systemic infection can influence neural dysfunction and …
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Assessment of the Novel Neuronal Synuclein Disease Staging System in Stratifying Dementia with Lewy Bodies Patients
… of "the neuronal synuclein disease (NSD) integrated staging system,” originally designed for PD, in people with … translational research on DLB. We will use the NSD staging system to categorize patients within the E-DLB that have … of Parkinson’s disease: Application of the NSD staging system in DLB should reduce diagnostic variability and …
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