… disease networks. Hypothesis:  We hypothesize that systems-based approaches, combined with complex genetics, … of potential therapeutics against identified targets. This system can also be used to test whether an intervention is …

… with a downstream selective impact on the dopaminergic system. It is thus reasonable to surmise that the primary, … related to the link between LRRK2 function and the immune system.   Project Description:              The first goal … Most importantly, if treatment targeting the immune system is administered early in a subject-at-risk life, it …

… we propose to analyze existing skin samples from the MJFF Systemic Synuclein Sampling Study (S4). Hypothesis:  We …

… this, to explore a function for LRRK2 in the immune system. Several laboratories including ours determined that … hope to have shown that LRRK2 has a function in the immune system, which will undoubtedly inform efforts to develop … in humans. … Inflammation … LRRK2 … LRRK2 in the Immune System … Michael G. Schlossmacher, MD … Julianna J. …

… a publication in Lancet Neurology proposing a new staging system for Neuronal Synuclein Disease (NSD). As part of the … several letters raising questions about the staging system and definition of NSD. On June 12, 2024, Lancet … conversation surrounding NSD and its accompanying staging system.   A global team of researchers published a paper in …

… Study Design:  We will begin by modifying and improving our system to facilitate future regulatory approval. We will …