-
Investigation of Neuroinflammation in LRRK2 Mutation Carriers Using Positron Emission Tomography
… with a downstream selective impact on the dopaminergic system. It is thus reasonable to surmise that the primary, … related to the link between LRRK2 function and the immune system. Project Description: The first goal … Most importantly, if treatment targeting the immune system is administered early in a subject-at-risk life, it …
-
LRRK2 Regulates Host Response to Microbial Infections
… this, to explore a function for LRRK2 in the immune system. Several laboratories including ours determined that … hope to have shown that LRRK2 has a function in the immune system, which will undoubtedly inform efforts to develop … LRRK2 in the Immune System …
-
Proteomic analysis of accumulated proteins in dopaminergic neurons using a pre-clinical model ofubiquitin-proteasome system dysfunction
… that degrades them. Failure of this protein degradation system in dopamine neurons is believed to contribute to the …
-
Using a Systems-based Approach to Study the Molecular Processes Underlying Parkinson’s Disease: The Foundational Data Initiative
… disease networks. Hypothesis: We hypothesize that systems-based approaches, combined with complex genetics, … of potential therapeutics against identified targets. This system can also be used to test whether an intervention is …
-
Analysis of Skin Biopsies from the Systemic Synuclein Sampling Study by Alpha-synuclein Seed Amplification Assay
… we propose to analyze existing skin samples from the MJFF Systemic Synuclein Sampling Study (S4). Hypothesis: We …
-
The Four Horsemen of G2019S
… G2019S variant of LRRK2 are abnormally sensitive to immune system molecules that naturally increase in the body with … LRRK2 in the Immune System …