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LRRK2 Regulates Host Response to Microbial Infections
… Michael G. Schlossmacher, MD … Julianna J. Tomlinson, PhD … Dana Philpott, PhD …
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Using a Systems-based Approach to Study the Molecular Processes Underlying Parkinson’s Disease: The Foundational Data Initiative
… disease networks. Hypothesis: We hypothesize that systems-based approaches, combined with complex genetics, … of potential therapeutics against identified targets. This system can also be used to test whether an intervention is …
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Analysis of Skin Biopsies from the Systemic Synuclein Sampling Study by Alpha-synuclein Seed Amplification Assay
… we propose to analyze existing skin samples from the MJFF Systemic Synuclein Sampling Study (S4). Hypothesis: We …
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New Biological Definition and Proposed Staging System for PD: What it means for Researchers, Industry Professionals and Clinicians
January 29, 2024
… a publication in Lancet Neurology proposing a new staging system for Neuronal Synuclein Disease (NSD). As part of the … several letters raising questions about the staging system and definition of NSD. On June 12, 2024, Lancet … conversation surrounding NSD and its accompanying staging system. A global team of researchers published a paper in …
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The Four Horsemen of G2019S
… G2019S variant of LRRK2 are abnormally sensitive to immune system molecules that naturally increase in the body with … … Inflammation … California … LRRK2 … LRRK2 in the Immune System … Theo D. Palmer, PhD …
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Translation of the Neuroprotective Immune Modulator LBT-3627 into First-In-Human Studies
… well as people with PD who exhibit a dysfunctional immune system. Participants will be treated with a single dose of … in terms of future PD clinical trials. … Adaptive immune system … autoimmunity … Clinical trials … disease … tolerance … Inflammation … neuroimmune … peripheral immune system … t cell … 2022: Accelerated Therapeutics Program … …