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Stuart C. Sealfon, MD
… of Medicine and Professor of Neurobiology, Pharmacology and Systems Therapeutics. His laboratory applies diverse systems biology approaches to achieve a better understanding … signals. His research focuses on studying signaling systems, which are critical for understanding cell responses …
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Shalini Narayana, MBBS, PhD
… research emphasis is on examining the changes in the neural systems that result from neurological disorders, training, … imaging to study both normal and disordered speech motor systems. Dr. Narayana has focused on examining examined alterations in the speech motor system in patients with Parkinson’s disease, as well as its …
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Physiological Role of Lysosomal LRRK2 in the Regulation of CMA
… Brain cells rely on very efficient surveillance systems to identify defective components and break them … Project Description: These researchers have developed systems that permit them to reconstitute each of the steps … to their delivery and destruction in the cellular cleaning systems. Using these methods, they intend to add normal …
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LRRK2 Safety Initiative
… LRRK2 kinase inhibitors in the clinic. If we confirm that multiple LRRK2 kinase inhibitors are a safety liability, we …
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Identification of binding proteins for alpha-synuclein oligomers in brain and cells
… therapies. Final Outcome Dr. Jensen successfully identified multiple oligomer-specific targets. He is now conducting a …
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Rita Balice-Gordon, PhD
… and gene therapy for patients with rare genetic disorders, multiple sclerosis and neurodegenerative diseases. She …