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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Biomarkers, 2009
    Development of an mGluR5 Imaging Marker for Parkinson's Disease

    Objective/Rationale
    The goal of this proposal is to develop an imaging test, 18F-PEB PET, to assess glutamate function in the brain of individuals with Parkinson disease (PD) and determine if the...

  • Biomarkers, 2009
    High Resolution Diffusion Tensor MRI Imaging as a Biomarker of Parkinson's Disease Diagnosis and Disease Progression

    Objective/Rationale
    As Parkinson’s disease (PD) is moving into the era of neuroprotective interventions one of the major objectives is the development of a biomarker of PD diagnosis.  This study...

  • Biomarkers, 2009
    Development of an alpha6*-Selective Neuronal Nicotinic Receptor (NNR) Imaging Agent as a Parkinson's Disease Biomarker

    Objective/Rationale
    The availability of a selective PET radiotracer for the drug target is critical for determining receptor occupancy in humans. NNR subtypes containing the alpha? subunit have been...

  • Biomarkers, 2009
    High Resolution Diffusion Tensor Imaging in Parkinson's Disease and Parkinson Plus Syndromes

    Objective/Rationale
    An objective and valid trait and state biomarker of Parkinson’s disease will help therapeutic development by providing a measure to help confirm diagnosis (trait), and track...

  • Rapid Response Innovation Awards, 2009
    Possibility of Small Molecule Activation of PINK1 Kinase Activity

    Objective/Rationale
    Many genetic disorders are caused by the loss of a functional protein which protects cells from disease. These disorders are difficult to treat with drugs because most drugs block...

  • MJFF Research Grant, 2009
    Supplemental Biomarkers Study to Clinical Trial for CoQ10

    Objective/Rationale
    There is a critical need for biomarkers of Parkinson’s disease (PD), for accurate and earlier diagnosis, and for monitoring treatment effects. We are investigating two potential...

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