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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • 2022: Accelerated Therapeutics Program, 2022
    Translation of the Neuroprotective Immune Modulator LBT-3627 into First-In-Human Studies

    Study Rationale: LBT-3627 is a disease-modifying therapeutic candidate that has been shown to reduce brain inflammation and immune imbalance in preclinical models of Parkinson's disease (PD). A recent...

  • Fall 2021 RFA: Promoting Diversity, Equity and Inclusion in Parkinson’s Disease Research, 2022
    Disparities in Neurocognitive Impairment Among Hispanics and Latinos in the United States with Parkinson’s Disease: The Role of Cardiovascular Risk

    Study Rationale: In the United States, Latinos with Parkinson’s disease (PD) are more likely to have problems with memory, planning and other thinking skills than individuals of other ethnic/racial...

  • Diversity, Equity and Inclusivity in Parkinson's research, 2022
    Identifying Barriers and Motivators Associated with Access to Care and Participation in Genetic Research Studies for Parkinson's Disease among Asian Americans

    Study Rationale: Clinicians have observed that Asian Americans are older and have had symptoms for a longer period of time than Whites when they are diagnosed with Parkinson’s disease (PD). In...

  • Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022
    Assessment of Alpha-synuclein Aggregation Inhibitor ASN121151 as a Potential New Treatment for Parkinson’s Disease

    Study Rationale: Genetic defects in the gene encoding alpha-synuclein cause the protein to aggregate in the brains of people with a familial form of Parkinson’s disease (PD). We have developed a novel...

  • Fall 2020 RFA: Therapeutic Pipeline Program-Pre-Clinical, 2022
    Targeting Colony-stimulating Factor 1 Receptor (CSF1R) to Modify Disease Progression in Preclinical Experimental Models of Parkinson’s Disease

    Study Rationale: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by pronounced neuroimmune dysfunction. Although the disease is very common, no therapy is available...

  • 2022: Accelerated Therapeutics Program, 2022
    Using Small Molecules that Modulate Mitochondrial Function for the Treatment of Parkinson's Disease

    Study Rationale: Dysfunction in energy-producing structures called mitochondria is a crucial driver of the initiation and progression of Parkinson’s disease (PD). Mitochondria in the cells of people...

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