The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Biology Consortium, 2017From Structure to Function: Targeting LRRK2-mediated Parkinson's Disease
Study Rationale:
Parkinson's disease (PD) mutations in the LRRK2 protein have been linked to decreased GTPase (enzyme that binds to G proteins) activity and increased kinase (enzyme that modifies a... -
LRRK2 Biology Consortium, 2017Consequences of LRRK2 Rab Phosphorylation in Neurons and Astrocytes
Study Rationale:
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are important contributors to LRRK2-linked Parkinson's disease (PD); therefore, LRRK2 is an important drug target. The goal... -
Improved Biomarkers and Clinical Outcome Measures, 2016Supramolecular Hosts as Combined Protein Aggregation Inhibitors and Hyperpolarized MRI Reporters
Study Rationale:
Amyloid fibrils play a key role in Parkinson's disease (PD) and monitoring of their formation from self‐assembled insoluble molecular aggregates would be extremely valuable as a... -
Research Grant, 2016Parkinson's Disease Genetics Sequencing Consortium
Study Rationale:
The Parkinson's Disease Genetics Sequencing Consortium (PDGSC) was established following a National Institute of Neurological Disorders and Stroke workshop in June 2014 and brings... -
Research Grant, 2017Validation of the Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB) for Parkinson's Disease
Study Rationale:
The US Food and Drug (FDA) requires acceptable outcome measures to approve a cognitive-enhancing medication for the treatment of mild cognitive impairment (MCI) in Parkinson's disease... -
Research Grant, 2017A Proof-of-Concept Study of Mitochondrial Drugs in Pre-Clinical Models of Parkinson’s Disease
Study Rationale:
Mitochondrial dysfunction (powerhouse of the cell), free-radical induced injury (highly reactive atoms that can be harmful) and inflammatory mechanisms have been proposed to play a...
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Our funding programs support basic, translational and clinical research from academia and industry.