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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Improved Biomarkers and Clinical Outcome Measures, 2019
    International Validation of Two Non-motor Symptom Scales in Parkinson’s Disease

    Study Rationale:
    Non-motor Parkinson’s symptoms can fluctuate with dopaminergic medication effectiveness. Anxiety, sadness, lack of energy and fatigue are common symptoms during the off-medication...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Investigation of a Novel Therapeutic Approach for Non-motor Symptoms of Parkinson’s Disease

    Study Rationale:                  

    Parkinson's disease (PD) is characterized by both motor symptoms and non-motor symptoms. While progress has been made in addressing motor symptoms, non-motor...

  • Summer 2025 RFA: Personalized Approaches for Understanding, Assessing and Improving Gait in Parkinson’s Disease Research Program, 2025
    Predicting Freezing of Gait in Parkinson’s Disease: An Objective Quantitative Exploration Combining Patient Perception with Multi-Dimensional Digital Gait Analysis & Multi-Domain Cognitive Testing

    Study Rationale: Freezing of gait (FOG) is a debilitating – and not well understood - symptom impacting many patients with Parkinson’s disease (PwPD). FOG can occur during any stage of the disease but...

  • Defining Cognitive Phenotypes of Parkinson’s Disease, 2011
    The Relationship Between Cognitive Phenotypes of PD with Visual Hallucinations and 5HT2A Receptors in the Inferotemporal Cortex

    Objective/Rationale:
    The project aims to understand the mechanisms underlying cognitive deficits that are associated with visual hallucinations (VH) in Parkinson’s disease (PD). We have previously...

  • Repositioning Drugs for PD, 2011
    Evaluation of a Specific DAT Inhibitor in Pre-clinical Models of Parkinson's Disease

    Objective/Rationale: 
    MLR-1017 is a psychostimulant drug used clinically for a variety of neuropsychiatric and other applications, but has never been tested in Parkinson’s disease (PD). Levodopa is a...

  • Therapeutic Pipeline Program, 2015
    Improving Access to Depression Care in Parkinson’s Disease: A Telehealth Approach

    Study Rationale:                   
    There is a critical need for treatments that address depression and barriers to care among the approximately 5 million people living with Parkinson’s disease (PD)...

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