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John A. Gruner, PhD

Director of Neurophysiology, Senior Scientific Fellow at Melior Discover, Inc.

Location: Exton, PA United States

Dr. Gruner received his BA from University of California, San Diego, and PhD at Purdue University, where he investigated the role of the cerebellum in motor control. He subsequently was research assistant professor in the Dept. of Neurosurgery at NYU where he designed stimulation systems for paralyzed muscle, and implemented electrophysiological and behavior methods to evaluate treatment efficacy in the NYU spinal cord injury model he co-developed. At Cephalon, Inc., he designed and supervised neurophysiological and pharmacological studies in numerous neurological disease areas, including neuroprotection in neuropathy, neurodegeneration, traumatic (spinal) injury, and motor neuron disease models; mechanisms of action analgesic agents; and actions of drugs on sleep and wake activity. He was a critical discovery team member for an H3 receptor antagonist currently in clinical development. At Melior Discovery, he has developed pre-clinical EEG models for evaluating seizure liability, and is investigating neurophysiological models for evaluating drug efficacy in schizophrenia and cognitive disorders.

Associated Grants

  • Evaluation of a Specific DAT Inhibitor in Pre-clinical Models of Parkinson's Disease


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