MJFF Publications

Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection

2025

OPEN

Title: Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection

Author(s): Debotri Chatterjee, Drishya Kurup, Richard J. Smeyne

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

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Publication Date: 2025-04-23

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1038/s41531-025-00925-0

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Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein

2025

OPEN

Title: Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein

Author(s): Hope Pan, Melinda Balbirnie, Ke Hou, Naomi S. Sta Maria, Shruti Sahay, Paul Denver, Stefano Lepore, Mychica Jones, Xiaohong Zuo, Chunni Zhu, Hilda Mirbaha, Hedieh Shahpasand‐Kroner, Marisa Mekkittikul, Jiahui Lu, Carolyn J. Hu, Xinyi Cheng, Romany Abskharon, M.R. Sawaya, Christopher Kazu Williams, Harry V. Vinters, Russell E. Jacobs, Neil Harris, Gregory M. Cole, Sally A. Frautschy, David Eisenberg

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

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Publication Date: 2025-04-23

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1038/s41531-025-00918-z

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MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson’s HLA locus exhibits epigenetic regulation

2025

OPEN

Title: MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson’s HLA locus exhibits epigenetic regulation

Author(s): Elizabeth M. Kline, Janna Jernigan, Christopher D. Scharer, Jeffrey Maurer, Sakeenah L. Hicks, Mary K. Herrick, Rebecca L. Wallings, Sean D. Kelly, Jianjun Chang, Kelly B. Menees, Nikolaus R. McFarland, Jeremy M. Boss, Malú G. Tansey, Valerie Joers

Journal Name: Scientific Reports

Publisher: Springer Science and Business Media LLC

Vol: 15

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-21

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1038/s41598-025-95679-3

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Prioritizing Parkinson’s disease risk genes in genome-wide association loci

2025

OPEN

Title: Prioritizing Parkinson’s disease risk genes in genome-wide association loci

Author(s): Lara M. Lange, Catalina Cerquera Cleves, Marijn Schipper, Georgia Panagiotaropoulou, Alice Braun, Julia Kraft, Swapnil Awasthi, Nathaniel Bell, Daniëlle Posthuma, Stephan Ripke, Cornelis Blauwendraat, Karl Heilbron

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-16

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1038/s41531-025-00933-0

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Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration

2025

OPEN

Title: Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration

Author(s): Hélèna L. Denis, Aurélie de Rus Jacquet, Melanie Alpaugh, Michel Panisset, Roger A. Barker, Éric Boilard, Francesca Cicchetti

Journal Name: Fluids and Barriers of the CNS

Publisher: Springer Science and Business Media LLC

Vol: 22

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-14

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1186/s12987-025-00646-9

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Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques

2025

OPEN

Title: Additive effect of distant Lewy bodies and tau seeds injections on nigral degeneration in macaques

Author(s): Morgane Darricau, Valentine Kulifaj, Marie-Laure Arotçarena, Qin Li, Panagiotis Katsinelos, William A. McEwan, Maria Xilouri, Benjamin Dehay, Erwan Bézard, Vincent Planche

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-13

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1038/s41531-025-00938-9

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Astrocytic RNA editing regulates the host immune response to alpha-synuclein

2025

OPEN

Title: Astrocytic RNA editing regulates the host immune response to alpha-synuclein

Author(s): Karishma D’Sa, Minee-Liane Choi, Aaron Z. Wagen, Núria Setó‐Salvia, Olga Kopach, James R. Evans, Margarida Rodrigues, Patricia Lopez-Garcia, Joanne Lachica, Benjamin Clarke, Jaijeet Singh, Ali Ghareeb, James Bayne, Melissa Grant‐Peters, Sonia García-Ruiz, Zhongbo Chen, Samuel G. Rodriques, Dilan Athauda, Emil K. Gustavsson, Sarah A. Gagliano Taliun, Christina E. Toomey, Regina H. Reynolds, George R. Young, Stephanie Strohbuecker, Thomas T. Warner, Dmitri A. Rusakov, Rickie Patani, Clare Bryant, David Klenerman, Sonia Gandhi, Mina Ryten

Journal Name: Science Advances

Publisher: American Association for the Advancement of Science (AAAS)

Vol: 11

Issue #: 15

Start Page:

End Page:

Publication Date: 2025-04-11

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1126/sciadv.adp8504

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Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

2025

OPEN

Title: Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

Author(s): Moriah R. Arnold, Gabriel Cohn, Kezia Catharina Oxe, Somarr N. Elliott, Cindy Moore, Allison May Zhou, Peter V. Laraia, Sahar Shekoohi, Dillon Brownell, Rosalie C. Sears, R. L. Woltjer, Charles K. Meshul, Stephan N. Witt, Dorthe Helena Larsen, Vivek K. Unni

Journal Name: Science Advances

Publisher: American Association for the Advancement of Science (AAAS)

Vol: 11

Issue #: 15

Start Page:

End Page:

Publication Date: 2025-04-09

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1126/sciadv.adq2519

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GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

2025

OPEN

Title: GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau

Author(s): Diana Acosta Ingram, Emir Turkes, Tae Yeon Kim, S.T. Vo, Nicholas Sweeney, Marie-Amandine Bonte, Ryan Rutherford, Dominic Julian, Meixia Pan, Jacob Marsh, Andrea R. Argouarch, Min Wu, Douglas W. Scharre, Erica H. Bell, Lawrence S. Honig, Jean Paul Vonsattel, Geidy E. Serrano, Thomas G. Beach, Celeste M. Karch, Aimee W. Kao, Mark E. Hester, Xianlin Han, Hongjun Fu

Journal Name: Nature Communications

Publisher: Springer Science and Business Media LLC

Vol: 16

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-09

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1038/s41467-025-58585-w

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Tet2 loss and enhanced ciliogenesis suppress α-synuclein pathology

2025

OPEN

Title: Tet2 loss and enhanced ciliogenesis suppress α-synuclein pathology

Author(s): Quansah Emmanuel, Naman Vatsa, Elizabeth Ensink, Jaycie Brown, Tyce Cave, Miguel Aguileta, Emily Schulz, Allison Lindquist, Carla Gilliland, Jennifer A. Steiner, Martha L. Escobar Galvis, Milda Milčiūtė, Michael X. Henderson, Patrik Brundin, Lena Brundin, Lee Marshall, Juozas Gordevičius

Journal Name: Acta Neuropathologica Communications

Publisher: Springer Science and Business Media LLC

Vol: 13

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-07

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1186/s40478-025-01988-z

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Application of new biologic disease criteria for synucleinopathies to the systemic synuclein sampling study cohort

2025

OPEN

Title: Application of new biologic disease criteria for synucleinopathies to the systemic synuclein sampling study cohort

Author(s): Lana M. Chahine, Michael C. Brumm, A R Nair, Sherri Mosovsky, Nicole K. Polinski, Thomas G. Beach, Brit Mollenhauer, Charles H. Adler

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-05

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41531-025-00919-y

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Characterization of Isolated Human Astrocytes from Aging Brain

2025

OPEN

Title: Characterization of Isolated Human Astrocytes from Aging Brain

Author(s): Geidy E. Serrano, Sidra Aslam, Jessica E. Walker, Ignazio S. Piras, Matthew J. Huentelman, Richard Arce, Michael J. Glass, Anthony J. Intorcia, Katsuko E. Suszczewicz, Claryssa I. Borja, Madison P. Cline, Sanaria H. Qiji, Ileana Lorenzini, Suet Theng Beh, Monica Mariner, Addison Krupp, Rylee McHattie, Anissa Shull, Zekiel R. Wermager, Thomas G Beach

Journal Name: International Journal of Molecular Sciences

Publisher: MDPI AG

Vol: 26

Issue #: 7

Start Page: 3416

End Page: 3416

Publication Date: 2025-04-05

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.3390/ijms26073416

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Hyposmia in Parkinson’s disease; exploring selective odour loss

2025

OPEN

Title: Hyposmia in Parkinson’s disease; exploring selective odour loss

Author(s): Eleanor Mitchell, Christian Mattjie, Jonathan P. Bestwick, Rodrigo C. Barros, Artur Francisco Schumacher Schuh, Cristina Simonet, Alastair Noyce

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-04

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41531-025-00922-3

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Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures

2025

OPEN

Title: Seeding-competent early tau multimers are associated with cell type-specific transcriptional signatures

Author(s): Rahel Feleke, Simona Jogaudaite, Elisavet Velentza‐Almpani, Leung Yeung-Yeung, Daniel Clode, Jeong Hun Ko, Ben Shin, S. Matthews, Maria Otero‐Jimenez, Marcelina J. Wojewska, Sandra Gray‐Rodriguez, Sarah J. Marzi, Maxwell P. Spires-Jones, Tara L. Spires‐Jones, Michael R. Johnson, Javier Alegre‐Abarrategui

Journal Name: Acta Neuropathologica

Publisher: Springer Science and Business Media LLC

Vol: 149

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-04

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1007/s00401-025-02869-4

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Fears and uncertainties of people with Parkinson's disease

2025

OPEN

Title: Fears and uncertainties of people with Parkinson's disease

Author(s): Esme D. Trahair, Darby Steiger, Naomi Lowe, Robyn Rapoport, Caitlin Kelliher, Stephanie Benvengo, Catherine Kopil, Lana M. Chahine, Connie Marras, Sneha Mantri

Journal Name: Journal of Parkinson’s Disease

Publisher: SAGE Publications

Vol:

Issue #:

Start Page:

End Page:

Publication Date: 2025-04-03

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1177/1877718x251328565

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Systematic review and consensus conceptual model of meaningful symptoms and functional impacts in early Parkinson’s Disease

2025

OPEN

Title: Systematic review and consensus conceptual model of meaningful symptoms and functional impacts in early Parkinson’s Disease

Author(s): Jennifer R. Mammen, Jamie Adams, Rikki Mangrum, Yuge Xiao, William Barbosa, Mirinda Tyo, Christopher Redmond, C. Carter, Kelly Cifelli, Robert Cifelli, Hope Maruzo, J. F. Meeker, Gerry Shultz, Charles R. Thomas, Claire Bale, Evan Davies, Catherine Kopil, Connie Marras, Tiago Mestre, Thomas Morel, Tanya Simuni, Glenn T. Stebbins, Daniel Weintraub, Diane Stephenson

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-04-03

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41531-025-00907-2

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Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2

2025

OPEN

Title: Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2

Author(s): Jan Philipp Dobert, Jan-Hannes Schäfer, Thomas Dal Maso, P. N. Ravindran, Dustin J. E. Huard, Eileen Socher, Lisa A. Schildmeyer, Raquel L. Lieberman, Wim Versées, Arne Moeller, Friederike Zunke, Philipp Arnold

Journal Name: Nature Communications

Publisher: Springer Science and Business Media LLC

Vol: 16

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-03-30

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41467-025-58340-1

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An integrative network approach for longitudinal stratification in Parkinson’s disease

2025

OPEN

Title: An integrative network approach for longitudinal stratification in Parkinson’s disease

Author(s): Barry Ryan, Riccardo E. Marioni, T. Ian Simpson

Journal Name: PLOS Computational Biology

Publisher: Public Library of Science (PLoS)

Vol: 21

Issue #: 3

Start Page: e1012857

End Page: e1012857

Publication Date: 2025-03-28

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1371/journal.pcbi.1012857

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Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

2025

OPEN

Title: Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

Author(s): Ching‐Chieh Chou, Ryan T. Vest, Miguel A. Prado, Joshua Wilson‐Grady, João A. Paulo, Yohei Shibuya, Patricia Moran‐Losada, Ting-Ting Lee, Jian Luo, Steven P. Gygi, Jeffery W. Kelly, Daniel Finley, Marius Wernig, Tony Wyss‐Coray, Judith Frydman

Journal Name: Nature Cell Biology

Publisher: Springer Science and Business Media LLC

Vol: 27

Issue #: 4

Start Page:

End Page:

Publication Date: 2025-03-26

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41556-025-01623-y

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Association between serum sodium and sporadic Parkinson’s disease

2025

OPEN

Title: Association between serum sodium and sporadic Parkinson’s disease

Author(s): Wen Zhou, Qingqing Xia, Duan Liu, Junying Li, Liang Gong

Journal Name: Frontiers in Neuroscience

Publisher: Frontiers Media SA

Vol: 19

Issue #:

Start Page:

End Page:

Publication Date: 2025-03-25

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.3389/fnins.2025.1555831

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The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population

2025

OPEN

Title: The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population

Author(s): Lara M. Lange, Kristin Levine, Susan H. Fox, Connie Marras, Nazish Rafique, Nicole Kuznetsov, Dan Vitale, Hirotaka Iwaki, Katja Lohmann, Luca Marsili, Alberto J. Espay, Peter Bauer, Christian Beetz, Jessica Martin, Stewart A. Factor, Lenora A. Higginbotham, Honglei Chen, Hampton L. Leonard, M. A. Nalls, Niccoló E. Mencacci, Huw R. Morris, Andrew Singleton, Christine Klein, Cornelis Blauwendraat, Zih‐Hua Fang, Emilia Gatto, Marcelo Kauffman, Samson Khachatryan, Zaruhi Tavadyan, Claire E. Shepherd, Julie Hunter, Kishore R. Kumar, Melina Ellis, Miguel E. Rentería, Sulev Kõks, Alexander Zimprich, Artur Francisco Schumacher Schuh, Carlos Roberto de Mello Rieder, Paula Saffie Awad, Vítor Tumas, Sarah Camargos, Edward A. Fon, Oury Monchi, Ted Fon, Benjamin Pizarro Galleguillos, Patricio Olguı́n, Marcelo Miranda, M. Leonor Bustamante, Pedro Chaná, Beisha Tang, Huifang Shang, Jifeng Guo, Piu Chan, Wei Luo, Gonzálo Arboleda, Jorge Orozco, Marlene Jiménez-Del-Río, Álvaro Hernández-Flores, Mohamed Salama, Walaa A. Kamel, Yared Z. Zewde, Alexis Brice, Jean‐Christophe Corvol, Ana Westenberger, Eva‐Juliane Vollstedt, Harutyun Madoev, Joanne Trinh, Johanna Junker, Anastasia Illarionova, Brit Mollenhauer, Franziska Hopfner, Günter U. Höglinger, Manu Sharma, Thomas Gasser, Sergiu Groppa, Albert Akpalu, Georgia Xiromerisiou, Georgios Hadjigorgiou, Efthymios Dadiotis, Ioannis E. Dagklis, Ioannis Tarnanas, Leonidas Stefanis, María Stamelou, Alex Medina, Germaine Hiu-Fai Chan, Nelson Yuk-Fai Cheung, Nancy Y. Ip, Phillip Chan, Xiaopu Zhou, Asha Kishore, Divya KP, Pramod Kr. Pal, Prashanth Lingappa Kukkle, Roopa Rajan, Rupam Borgohain, Mehri Salari, Andrea Quattrone, Monica Gagliardi, Enza Maria Valente, Micol Avenali, Grazia Annesi, Lucilla Parnetti, Tommaso Schirinzi, Manabu Funayama, Nobutaka Hattori, Tomotaka Shiraishi, Altynay Karimova, Gulnaz Kaishibayeva, Cholpon Shambetova, Rejko Krüger, Ai Huey Tan, Azlina Ahmad‐Annuar, Shen‐Yang Lim, Yi Wen Tay, Norlinah Mohamed Ibrahim, Nor Azian Abdul Murad, Shahrul Azmin, Wael Mohamed, Daniel Martinez‐Ramirez, Mayela Rodríguez‐Violante, Paula Reyes‐Pérez, Bayasgalan Tserensodnom, Rajeev Ojha, Tim Anderson, Toni L. Pitcher, Arinola Sanyaolu, Njideka Okubadejo, Oluwadamilola O. Ojo, Jan Aasly, Lasse Pihlstrøm, Manuela Tan, Shoaib Ur-Rehman, Mario Cornejo‐Olivas, Maria Leila M. Doquenia, Raymond L. Rosales, Ángel Viñuela, Е. А. Яковенко, Bashayer Al Mubarak, Muhammad Umair, Eng‐King Tan, Jia Nee Foo, Ferzana Amod, Jonathan Carr, Soraya Bardien, Beomseok Jeon, Yun Joong Kim, Esther Cubo, Ignacio Álvarez, Janet Hoenicka, Katrin Beyer, María Teresa Periñán, Pau Pástor, Sarah El-Sadig, Kajsa Brolin, Christiane Zweier, Paul Krack, Gerd Tinkhauser, Chin‐Hsien Lin, Pin-Jui Kung, Hsiu-Chuan Wu, Ruey‐Meei Wu, Yih‐Ru Wu, Rim Amouri, Samia Ben Sassi, A. Nazlı Başak, Özgür Öztop Çakmak, Sibel Ertan, Gençer Genç, Alastair Noyce, Sumit Dey, Alejandro Martínez-Carrasco, Anette Schrag, Anthony H.V. Schapira, Eleanor J. Stafford, Henry Houlden, John Hardy, Kin Y. Mok, Mie Rizig, Nicholas Wood, Olaitan Okunoye, Rauan Kaiyrzhanov, Rimona S. Weil, Simona Jasaityte, Vida Obese, Camille Carroll, Claire Bale, Donald G. Grosset, Nigel Williams, Patrick A. Lewis, Seth Love, Simon Stott, Caroline B. Pantazis, Katherine M. Andersh, Laurel Screven, Sara Bandrés‐Ciga, Ignacio Juan Keller Sarmiento, Alyssa O’Grady, Bernadette Siddiqi, Bradford Casey, Brian Fiske, Charisse Comart, Justin Solle, Kaileigh Murphy, Maggie Kuhl, Naomi Louie, Sohini Chowdhury, Todd Sherer, Andrew K. Sobering, Cabell Jonas, Carlos Cruchaga, Laura Ibáñez, Claire Wegel, Tatiana Foroud, Deborah A. Hall, Dena G. Hernandez, Jonggeol Jeff Kim, Yeajin Song, Ejaz Shiamim, Ekemini Riley, Geidy E. Serrano, Ignácio F. Mata, Miguel Inca‐Martinez, Jared Williamson, Joseph Jankovic, Joshua Shulman, Kamalini Ghosh Galvelis, Karen Nuytemans, Karl Kieburtz, Katerina Markopoulou, Kenneth Marek, Lana M. Chahine, Lauren Ruffrage, Lisa Shulman, Marissa Dean, Matthew J. Farrer, Megan J. Puckelwartz, Steven Lubbe, Roger L. Albin, Roy N. Alcalay, Ruth Walker, Sonya B. Dumanis, Tao Xie, Thomas Beach, Faraz Faghri, Mary B. Makarious, Mathew J. Koretsky, Duan Nguyen, Toan Nguyen, Masharip Atadzhanov

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-03-25

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41531-025-00896-2

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Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner

2025

OPEN

Title: Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner

Author(s): Moriah R. Arnold, Suzie Chen, Vivek K. Unni

Journal Name: Frontiers in Oncology

Publisher: Frontiers Media SA

Vol: 15

Issue #:

Start Page:

End Page:

Publication Date: 2025-03-20

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.3389/fonc.2025.1554059

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Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo

2025

OPEN

Title: Spatial genomics of AAV vectors reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo

Author(s): Gerard Michael Coughlin, Máté Borsos, Bre’Anna H. Barcelona, Nathan Appling, Acacia M Hori, Elisha D.W. Mackey, Rana Eser, Cameron Jackson, Xinhong Chen, Sripriya Ravindra Kumar, Viviana Gradinaru

Journal Name: Nature Biotechnology

Publisher: Springer Science and Business Media LLC

Vol:

Issue #:

Start Page:

End Page:

Publication Date: 2025-03-20

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1038/s41587-025-02565-4

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The Exon-Based Transcriptomic Analysis of Parkinson’s Disease

2025

OPEN

Title: The Exon-Based Transcriptomic Analysis of Parkinson’s Disease

Author(s): Sulev Kõks

Journal Name: Biomolecules

Publisher: MDPI AG

Vol: 15

Issue #: 3

Start Page: 440

End Page: 440

Publication Date: 2025-03-19

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.3390/biom15030440

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PseudoSorter: A self-supervised spike sorting approach applied to reveal Tau-induced reductions in neuronal activity

2025

OPEN

Title: PseudoSorter: A self-supervised spike sorting approach applied to reveal Tau-induced reductions in neuronal activity

Author(s): Marius Brockhoff, Jakob Träuble, Sagnik Middya, Tanja Fuchsberger, Ana Fernández‐Villegas, Amberley D. Stephens, Miranda Robbins, Wenyue Dai, Belquis Haider, Sulay Vora, Nino F. Läubli, Clemens F. Kaminski, George G. Malliaras, Ole Paulsen, Gabriele S. Kaminski Schierle

Journal Name: Science Advances

Publisher: American Association for the Advancement of Science (AAAS)

Vol: 11

Issue #: 11

Start Page:

End Page:

Publication Date: 2025-03-14

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1126/sciadv.adr4155

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An axonal brake on striatal dopamine output by cholinergic interneurons

2025

OPEN

Title: An axonal brake on striatal dopamine output by cholinergic interneurons

Author(s): Yan-Feng Zhang, Pengwei Luan, Qinbo Qiao, Yiran He, Peter Zatka-Haas, Guofeng Zhang, Michael Z. Lin, Armin Lak, Miao Jing, Edward O. Mann, Stephanie J. Cragg

Journal Name: Nature Neuroscience

Publisher: Springer Science and Business Media LLC

Vol: 28

Issue #: 4

Start Page:

End Page:

Publication Date: 2025-03-13

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1038/s41593-025-01906-5

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Structure–Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1H-indoles as Tauopathy Positron Emission Tomography Radiotracers

2025

OPEN

Title: Structure–Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1H-indoles as Tauopathy Positron Emission Tomography Radiotracers

Author(s): Jeffrey S. Stehouwer, Guofeng Huang, Dinahlee Saturnino Guarino, Manik L. Debnath, Ashok Polu, Steven J. Geib, Brian J. Lopresti, Miloš D. Ikonomović, N. Scott Mason, Robert H. Mach, Chester A. Mathis

Journal Name: Journal of Medicinal Chemistry

Publisher: American Chemical Society (ACS)

Vol: 68

Issue #: 6

Start Page:

End Page:

Publication Date: 2025-03-11

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1021/acs.jmedchem.4c02988

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Radiosynthesis, In Vitro Characterization, and In Vivo PET Neuroimaging of [18F]F-4 for Tau Protein: A First-in-Human PET Study

2025

OPEN

Title: Radiosynthesis, In Vitro Characterization, and In Vivo PET Neuroimaging of [18F]F-4 for Tau Protein: A First-in-Human PET Study

Author(s): Anton Lindberg, Junchao Tong, Chao Zheng, André Mueller, Heiko Kroth, Andrew Stephens, Chester A. Mathis, Neil Vasdev

Journal Name: ACS Chemical Neuroscience

Publisher: American Chemical Society (ACS)

Vol: 16

Issue #: 6

Start Page:

End Page:

Publication Date: 2025-03-10

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1021/acschemneuro.4c00866

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LRRK2-associated parkinsonism with and without in vivo evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization

2025

OPEN

Title: LRRK2-associated parkinsonism with and without in vivo evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization

Author(s): Lana M. Chahine, David-Erick Lafontant, Seung Ho Choi, Hirotaka Iwaki, Cornelis Blauwendraat, Andrew Singleton, Michael C. Brumm, Roy N. Alcalay, Kalpana Merchant, Kelly Nudelman, Alain Dagher, Andrew Vo, Tao Qin, Charles S. Venuto, Karl Kieburtz, Kathleen L. Poston, Susan Bressman, Paulina González-Latapí, Brian Avants, Christopher S. Coffey, Danna Jennings, Eduardo Tolosa, Andrew Siderowf, Kenneth Marek, Tatyana Simuni, Kenneth Marek, Caroline M. Tanner, Tanya Simuni, Andrew Siderowf, Douglas Galasko, Lana M. Chahine, Christopher S. Coffey, Kalpana Merchant, Kathleen L. Poston, Roseanne D. Dobkin, Tatiana M. Foroud, Brit Mollenhauer, Dan Weintraub, Ethan G. Brown, Karl Kieburtz, Mark Frasier, Todd Sherer, Sohini Chowdhury, Roy N. Alcalay, Aleksandar Videnović, Duygu Tosun, Werner Poewe, Susan Bressman, Jan Hammer, Raymond James, Ekemini Riley, John Seibyl, Yi‐Ju Li, David G. Standaert, Sneha Mantri, Nabila Dahodwala, Michael A. Schwarzschild, Connie Marras, Hubert Fernandez, Ira Shoulson, Helen M. Rowbotham, Paola Casalin, Claudia Trenkwalder, Jamie L. Eberling, Katie Kopil, A. O'Grady, Maggie Kuhl, L. Kirsch, Tracy A. Willson, Emily Flagg, Bridget McMahon, Craig Stanley, Kim Fabrizio, Dixie Ecklund, Trevis Huff, Laura Heathers, Christopher Hobbick, Gena Antonopoulos, Chelsea Caspell‐Garcia, Michael C. Brumm, Arthur W. Toga, Karen Crawford, John E. Hamer, Doug Galasko, Andrew Singleton, Thomas J. Montine, Roseanne D. Dobkin, Monica Korell, Charles Adler, Amy W. Amara, Paolo Barone, Bastiaan R. Bloem, Kathrin Brockmann, Norbert Brüggemann, Kelvin L. Chou, Alberto J. Espay, Stewart A. Factor, Michelle Fullard, Robert Hauser, Penelope Hogarth, Shu-Ching Hu, Joshua Shulman, Stuart Isaacson, Christine Klein, Rejko Krueger, Mark Lew, Zoltan Mari, Maria José Martí, Nikolaus R. McFarland, Tiago Mestre, Emile Moukheiber, Alastair J. Noyce, Wolfgang H. Oertel, Njideka Okubadejo, Sarah A. O’Shea, Rajesh Pahwa, Nicola Pavese, Ron Postuma, Giulietta Riboldi, Lauren Ruffrage, Javier Ruiz‐Martínez, David A. Russell, Marie Saint‐Hilaire, Nancy Dos Santos, Wesley Schlett, Ruth B. Schneider, Holly Shill, David Shprecher, Leonidas Stefanis, Yen Tai, Arjun Tarakad, Eduardo Tolosa

Journal Name: Brain Communications

Publisher: Oxford University Press (OUP)

Vol: 7

Issue #: 2

Start Page:

End Page:

Publication Date: 2025-03-06

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1093/braincomms/fcaf103

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Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model

2025

OPEN

Title: Parkinson-like wild-type superoxide dismutase 1 pathology induces nigral dopamine neuron degeneration in a novel murine model

Author(s): Amr H. Abdeen, Benjamin G. Trist, Sara Nikseresht, R. J. Harwood, Stéphane Roudeau, Benjamin D. Rowlands, Fabian Kreilaus, Veronica Cottam, David Mor, Miriam Richardson, Julio C. Siciliano, Julia Forkgen, Greta Schaffer, Sian Genoud, Anne A. Li, Nicholas Proschogo, Bernadeth Antonio, Gerald Falkenberg, Dennis Brueckner, Kai Kysenius, Jeffrey R. Liddell, Sandrine Chan Moi Fat, Sharlynn Wu, Jennifer A. Fifita, Thomas E. Lockwood, David Bishop, Ian P. Blair, Richard Ortega, Peter J. Crouch, Kay L. Double

Journal Name: Acta Neuropathologica

Publisher: Springer Science and Business Media LLC

Vol: 149

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-03-05

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1007/s00401-025-02859-6

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Diffusion tensor subspace imaging of double diffusion–encoded MRI delineates small fibers and gray‐matter microstructure not visible with single encoding techniques

2025

OPEN

Title: Diffusion tensor subspace imaging of double diffusion–encoded MRI delineates small fibers and gray‐matter microstructure not visible with single encoding techniques

Author(s): Elizabeth Hutchinson, Jean‐Philippe Galons, Courtney Comrie, Thomas G. Beach, Geidy E. Serrano, Mark W. Bondi, Seraphina K. Solders, V. L. Galinsky, Lawrence R. Frank

Journal Name: Magnetic Resonance in Medicine

Publisher: Wiley

Vol: 93

Issue #: 6

Start Page:

End Page:

Publication Date: 2025-03-04

Open Access(OA) Status: OPEN

License: cc-by-nc

DOI - Digital Object Identifier: 10.1002/mrm.30463

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Male sex accelerates cognitive decline in GBA1 Parkinson’s disease

2025

OPEN

Title: Male sex accelerates cognitive decline in GBA1 Parkinson’s disease

Author(s): Stephanie Caminiti, Micol Avenali, Alice Galli, Rachele Malito, Giada Cuconato, Caterina Galandra, Rosaria Calabrese, Andrea Pilotto, Alessandro Padovani, Fabio Blandini, Daniela Perani, Cristina Tassorelli, Enza Maria Valente

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-03-04

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1038/s41531-025-00883-7

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Contribution of brain pericytes to neuroinflammation following repetitive head trauma

2025

OPEN

Title: Contribution of brain pericytes to neuroinflammation following repetitive head trauma

Author(s): Arianna Cembran, Maxwell Eisenbaum, Daniel Paris, Michael Mullan, Fiona Crawford, Scott Ferguson, Corbin Bachmeier

Journal Name: Journal of Inflammation

Publisher: Springer Science and Business Media LLC

Vol: 22

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-03-03

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1186/s12950-025-00439-9

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Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: A DNA co-methylation network analysis

2025

OPEN

Title: Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: A DNA co-methylation network analysis

Author(s): Joshua Harvey, Adam R. Smith, Luke Weymouth, Rebecca G. Smith, Isabel Castanho, Leon Hubbard, Byron Creese, Catherine Bresner, Nigel Williams, Ehsan Pishva, Katie Lunnon

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-03-02

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41531-025-00877-5

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Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson’s Disease Psychosis

2025

OPEN

Title: Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson’s Disease Psychosis

Author(s): Sara Pisani, Latha Velayudhan, Dag Aarsland, К. Ray Chaudhuri, Clive Ballard, Dominic ffytche, Sagnik Bhattacharyya

Journal Name: BMJ Mental Health

Publisher: BMJ

Vol: 28

Issue #: 1

Start Page: e301430

End Page: e301430

Publication Date: 2025-03-01

Open Access(OA) Status: OPEN

License: cc-by-nc

DOI - Digital Object Identifier: 10.1136/bmjment-2024-301430

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History of Traumatic Brain Injury Does Not Influence Rate of Progression of Clinical or Pathological Outcomes in Two Early Parkinson's Disease Cohorts

2025

OPEN

Title: History of Traumatic Brain Injury Does Not Influence Rate of Progression of Clinical or Pathological Outcomes in Two Early Parkinson's Disease Cohorts

Author(s): Angus McNamara, Irina Baetu, Lyndsey E. Collins‐Praino

Journal Name: European Journal of Neurology

Publisher: Wiley

Vol: 32

Issue #: 3

Start Page:

End Page:

Publication Date: 2025-03-01

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1111/ene.70090

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Plasma Glucosylceramide Levels Are Regulated by ATP10D and Are Not Involved in Parkinson's Disease Pathogenesis

2025

OPEN

Title: Plasma Glucosylceramide Levels Are Regulated by ATP10D and Are Not Involved in Parkinson's Disease Pathogenesis

Author(s): Emma N. Somerville, Alva James, Christian Beetz, Robert Schwieger, Gal Barrel, Krishna Kumar Kandaswamy, Marius I. Iurascu, Peter Bauer, Michael Ta, Hirotaka Iwaki, Konstantin Senkevich, Eric Yu, Roy N. Alcalay, Ziv Gan‐Or

Journal Name: Annals of Neurology

Publisher: Wiley

Vol: 97

Issue #: 5

Start Page:

End Page:

Publication Date: 2025-03-01

Open Access(OA) Status: OPEN

License:

DOI - Digital Object Identifier: 10.1002/ana.27219

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Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease

2025

OPEN

Title: Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease

Author(s): Shijun Yan, Wenjing Zhang, Xinying Li, Suman Dutta, Andrew R. Castle, Yiming Liu, Akhila K. Sahoo, C. Lam, Nicholas J.F. Gatford, Joshua Shulman, Chenzhong Li, Cheng Jiang, Bowen Shu, George K. Tofaris

Journal Name: Cell Reports Medicine

Publisher: Elsevier BV

Vol: 6

Issue #: 3

Start Page: 101999

End Page: 101999

Publication Date: 2025-03-01

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1016/j.xcrm.2025.101999

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A long-lived pool of PINK1 imparts a molecular memory of depolarization-induced activity

2025

OPEN

Title: A long-lived pool of PINK1 imparts a molecular memory of depolarization-induced activity

Author(s): Liam Pollock, Ioanna Ch. Georgiou, Emma V. Rusilowicz-Jones, Michael J. Clague, Sylvie Urbé

Journal Name: Science Advances

Publisher: American Association for the Advancement of Science (AAAS)

Vol: 11

Issue #: 9

Start Page:

End Page:

Publication Date: 2025-02-28

Open Access(OA) Status: OPEN

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DOI - Digital Object Identifier: 10.1126/sciadv.adr1938

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Benchmarking macaque brain gene expression for horizontal and vertical translation

2025

OPEN

Title: Benchmarking macaque brain gene expression for horizontal and vertical translation

Author(s): Andrea I. Luppi, Zhen-Qi Liu, Justine Y. Hansen, Rodrigo Cofré, Meiqi Niu, Elena Kuzmin, Seán Froudist‐Walsh, Nicola Palomero‐Gallagher, Bratislav Mišić

Journal Name: Science Advances

Publisher: American Association for the Advancement of Science (AAAS)

Vol: 11

Issue #: 9

Start Page:

End Page:

Publication Date: 2025-02-28

Open Access(OA) Status: OPEN

License:

DOI - Digital Object Identifier: 10.1126/sciadv.ads6967

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Quantifying arm swing in Parkinson’s disease: a method accounting for arm activities during free-living gait

2025

OPEN

Title: Quantifying arm swing in Parkinson’s disease: a method accounting for arm activities during free-living gait

Author(s): Erik Post, Twan van Laarhoven, Yordan P. Raykov, Max A. Little, Jorik Nonnekes, Tom Heskes, Bastiaan R. Bloem, Luc J. W. Evers

Journal Name: Journal of NeuroEngineering and Rehabilitation

Publisher: Springer Science and Business Media LLC

Vol: 22

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-26

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1186/s12984-025-01578-z

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A framework to standardize gait study protocols in Parkinson's disease

2025

OPEN

Title: A framework to standardize gait study protocols in Parkinson's disease

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Journal Name: Journal of Parkinson’s Disease

Publisher: SAGE Publications

Vol: 15

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-25

Open Access(OA) Status: OPEN

License: cc-by-nc

DOI - Digital Object Identifier: 10.1177/1877718x241305626

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Citation Count: 0

A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

2025

OPEN

Title: A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

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Journal Name: Nature Communications

Publisher: Springer Science and Business Media LLC

Vol: 16

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-25

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41467-025-56833-7

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Transcriptomic responses of lung mesenchymal cells during pneumonia

2025

OPEN

Title: Transcriptomic responses of lung mesenchymal cells during pneumonia

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Journal Name: JCI Insight

Publisher: American Society for Clinical Investigation

Vol: 10

Issue #: 7

Start Page:

End Page:

Publication Date: 2025-02-25

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1172/jci.insight.177084

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Citation Count: 0

RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress

2025

OPEN

Title: RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress

Author(s): Janna Jernigan, Hannah A. Staley, Zachary Baty, MacKenzie L. Bolen, Beatriz Maffini Gomes, Jenny Holt, Cassandra L. Cole, Noelle Neighbarger, Kruthika Dheeravath, Andrea R. Merchak, Kelly B. Menees, Stephen A. Coombes, Malú G. Tansey

Journal Name: Journal of Neuroinflammation

Publisher: Springer Science and Business Media LLC

Vol: 22

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-24

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1186/s12974-024-03322-1

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Citation Count: 0

Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant

2025

OPEN

Title: Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant

Author(s): Shen‐Yang Lim, Tzi Shin Toh, Jia Wei Hor, Jia Lun Lim, Lei Cheng Lit, Azlina Ahmad, Yi Wen Tay, Jia Nee Foo, Ebonne Yulin Ng, Kalai Arasu Muthusamy, Norlinah Mohamed Ibrahim, Khairul Azmi Ibrahim, Louis C.S. Tan, Jannah Zulkefli, Anis Nadhirah Khairul Anuar, Kirsten Black, Paweł Lis, Fei Xie, Zhidong Cen, Kai Shi Lim, Katja Lohmann, Shalini Padmanabhan, Dario R. Alessi, Wei Luo, Eng‐King Tan, Esther Sammler, Ai Huey Tan

Journal Name: npj Parkinson's Disease

Publisher: Springer Science and Business Media LLC

Vol: 11

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-23

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1038/s41531-025-00884-6

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Citation Count: 1

AskBeacon—Performing genomic data exchange and analytics with natural language

2025

OPEN

Title: AskBeacon—Performing genomic data exchange and analytics with natural language

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Journal Name: Bioinformatics

Publisher: Oxford University Press (OUP)

Vol: 41

Issue #: 3

Start Page:

End Page:

Publication Date: 2025-02-22

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1093/bioinformatics/btaf079

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Predicting Parkinson’s disease trajectory using clinical and functional MRI features: A reproduction and replication study

2025

OPEN

Title: Predicting Parkinson’s disease trajectory using clinical and functional MRI features: A reproduction and replication study

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Journal Name: PLOS ONE

Publisher: Public Library of Science (PLoS)

Vol: 20

Issue #: 2

Start Page: e0317566

End Page: e0317566

Publication Date: 2025-02-21

Open Access(OA) Status: OPEN

License: cc-by

DOI - Digital Object Identifier: 10.1371/journal.pone.0317566

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Exploring the early drivers of pain in Parkinson’s disease

2025

OPEN

Title: Exploring the early drivers of pain in Parkinson’s disease

Author(s): Shiying Liu, Douglas D. Gunzler, Steven A. Gunzler, Dana C. Crawford, Farren Briggs

Journal Name: Scientific Reports

Publisher: Springer Science and Business Media LLC

Vol: 15

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-20

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1038/s41598-025-90678-w

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Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei

2025

OPEN

Title: Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei

Author(s): Vasileios Theologidis, Sara A. Ferreira, Nanna Møller Jensen, Diana Gomes Moreira, Ole A. Ahlgreen, Mads W. Hansen, Emilie D. Rosenberg, Mette Richner, Islam Faress, Hjalte Gram, Poul Henning Jensen, Per Borghammer, Jens R. Nyengaard, Marina Romero‐Ramos, Christian B. Vægter, Wilma D.J. van de Berg, Nathalie Van Den Berge, Asad Jan

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Publisher: Springer Science and Business Media LLC

Vol: 13

Issue #: 1

Start Page:

End Page:

Publication Date: 2025-02-17

Open Access(OA) Status: OPEN

License: cc-by-nc-nd

DOI - Digital Object Identifier: 10.1186/s40478-025-01948-7

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