1101 - 1150 of 6509 Results
Title
Year
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OPENTitle: Neuroimmunology of the Interleukins 13 and 4Journal Name: Brain SciencesPublisher: MDPI AGVol: 6Issue #: 2Start Page: 18End Page: 18Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/brainsci6020018Best OA location URL: https://www.mdpi.com/2076-3425/6/2/18/pdf?version=1465804812Citation Count: 102
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OPENTitle: Substrate Reduction Therapy Reverses Mitochondrial, mTOR, and Autophagy Alterations in a Cell Model of Gaucher DiseaseJournal Name: CellsPublisher: MDPI AGVol: 10Issue #: 9Start Page: 2286End Page: 2286Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/cells10092286Best OA location URL: https://www.mdpi.com/2073-4409/10/9/2286/pdf?version=1630925823Citation Count: 13
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OPENTitle: A novel homozygous KY variant causing a complex neurological disorderJournal Name: European Journal of Medical GeneticsPublisher: Elsevier BVVol: 63Issue #: 11Start Page: 104031End Page: 104031Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.ejmg.2020.104031Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7554104Citation Count: 5
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OPENTitle: Systems-level neurophysiological state characteristics for drug evaluation in an animal model of levodopa-induced dyskinesiaJournal Name: Journal of NeurophysiologyPublisher: American Physiological SocietyVol: 115Issue #: 3Start Page: 1713End Page: 1729Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1152/jn.00868.2015Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4809970Citation Count: 24
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OPENTitle: Neuromodulation targets pathological not physiological beta bursts during gait in Parkinson's diseaseJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 120Issue #:Start Page: 107End Page: 117Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2018.09.004Best OA location URL: https://doaj.org/article/2232316968e3403b8d7208ad3725eaf1Citation Count: 125
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OPENTitle: Orientation selective deep brain stimulationJournal Name: Journal of Neural EngineeringPublisher: IOP PublishingVol: 14Issue #: 1Start Page: 016016End Page: 016016Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1088/1741-2552/aa5238Best OA location URL: http://doi.org/10.1088/1741-2552/aa5238Citation Count: 48
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OPENTitle: α-Synuclein seed amplification assay positivity beyond synucleinopathiesJournal Name: eBioMedicinePublisher: Elsevier BVVol: 120Issue #:Start Page: 105925End Page: 105925Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.ebiom.2025.105925Best OA location URL: https://doi.org/10.1016/j.ebiom.2025.105925Citation Count: 0
- Manual segmentation of the fornix, fimbria, and alveus on high-resolution 3T MRI: Application via fully-automated mapping of the human memory circuit white and grey matter in healthy and pathological aging2016OPENTitle: Manual segmentation of the fornix, fimbria, and alveus on high-resolution 3T MRI: Application via fully-automated mapping of the human memory circuit white and grey matter in healthy and pathological agingJournal Name: NeuroImagePublisher: Elsevier BVVol: 170Issue #:Start Page: 132End Page: 150Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuroimage.2016.10.027Citation Count: 74
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OPENTitle: New aspects of USP30 biology in the regulation of pexophagyJournal Name: AutophagyPublisher: Informa UK LimitedVol: 15Issue #: 9Start Page: 1634End Page: 1637Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/15548627.2019.1615304Best OA location URL: https://www.tandfonline.com/doi/pdf/10.1080/15548627.2019.1615304?needAccess=trueCitation Count: 14
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OPENTitle: LRRK2 deficiency impacts ceramide metabolism in brainJournal Name: Biochemical and Biophysical Research CommunicationsPublisher: Elsevier BVVol: 478Issue #: 3Start Page: 1141End Page: 1146Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bbrc.2016.08.082Best OA location URL: https://discovery.ucl.ac.uk/1508867/1/Plotegher.pdfCitation Count: 58
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OPENTitle: Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trialJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 18Issue #: 8Start Page: 724End Page: 735Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(19)30141-3Best OA location URL: https://resolver.sub.uni-goettingen.de/purl?gro-2/133481Citation Count: 112
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OPENTitle: Serotonergic pathology and disease burden in the premotor and motor phase of A53T α-synuclein parkinsonism: a cross-sectional studyJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 18Issue #: 8Start Page: 748End Page: 759Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(19)30140-1Best OA location URL: https://kclpure.kcl.ac.uk/ws/files/113416685/MainText_Politis_RevisedManuscript_Clean.pdfCitation Count: 88
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OPENTitle: Temporal Characteristics of High-Frequency Lower-Limb Oscillation during Freezing of Gait in Parkinson’s DiseaseJournal Name: Parkinson's DiseasePublisher: WileyVol: 2014Issue #:Start Page: 1End Page: 7Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1155/2014/606427Best OA location URL: https://downloads.hindawi.com/journals/pd/2014/606427.pdfCitation Count: 25
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OPENTitle: Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neuronsJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 69Issue #:Start Page: 263End Page: 275Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2014.05.012Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4135465Citation Count: 31
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OPENTitle: Effectiveness of home-based and remotely supervised aerobic exercise in Parkinson's disease: a double-blind, randomised controlled trialJournal Name: The Lancet NeurologyPublisher: Elsevier BVVol: 18Issue #: 11Start Page: 998End Page: 1008Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/s1474-4422(19)30285-6Best OA location URL: http://www.thelancet.com/article/S1474442219302856/pdfCitation Count: 460
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OPENTitle: Mitochondrial therapies for Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 25Issue #: S1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.22781Best OA location URL: http://doi.org/10.1002/mds.22781Citation Count: 58
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OPENTitle: A Nigro−Vagal Pathway Controls Gastric Motility and Is Affected in a Rat Model of ParkinsonismJournal Name: GastroenterologyPublisher: Elsevier BVVol: 153Issue #: 6Start Page: 1581End Page: 1593Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1053/j.gastro.2017.08.069Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5705565Citation Count: 97
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OPENTitle: Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patientsJournal Name: Toxicology ReportsPublisher: Elsevier BVVol: 4Issue #:Start Page: 188End Page: 193Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.toxrep.2017.03.005Best OA location URL: https://ars.els-cdn.com/content/image/1-s2.0-S221475001730015X-fx1_lrg.jpgCitation Count: 28
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OPENTitle: PREFACE: Divergent roles of ER stress in neurodegeneration and brain disordersJournal Name: Brain ResearchPublisher: Elsevier BVVol: 1648Issue #:Start Page: 527End Page: 529Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.brainres.2016.09.014Best OA location URL: https://www.sciencedirect.com/science/article/am/pii/S0006899316306229?via%3DihubCitation Count: 1
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OPENTitle: Chronic exposure to dopamine agonists affects the integrity of striatal D2 receptors in Parkinson's patientsJournal Name: NeuroImage: ClinicalPublisher: Elsevier BVVol: 16Issue #:Start Page: 455End Page: 460Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nicl.2017.08.013Best OA location URL: https://doi.org/10.1016/j.nicl.2017.08.013Citation Count: 33
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OPENTitle: Genetic analysis of FMR1 repeat expansion in essential tremorJournal Name: Neuroscience LettersPublisher: Elsevier BVVol: 593Issue #:Start Page: 114End Page: 117Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neulet.2015.03.027Best OA location URL: http://doi.org/10.1016/j.neulet.2015.03.027Citation Count: 13
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OPENTitle: RETRACTED: ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In VivoJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 22Issue #: 10Start Page: 1753End Page: 1767Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-saDOI - Digital Object Identifier: 10.1038/mt.2014.129Best OA location URL: http://www.cell.com/article/S1525001616307808/pdfCitation Count: 82
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OPENTitle: Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson′s diseaseJournal Name: Brain ResearchPublisher: Elsevier BVVol: 1531Issue #:Start Page: 37End Page: 47Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.brainres.2013.07.025Best OA location URL: http://doi.org/10.1016/j.brainres.2013.07.025Citation Count: 28
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OPENTitle: A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?Journal Name: HippocampusPublisher: WileyVol: 27Issue #: 1Start Page: 3End Page: 11Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/hipo.22671Best OA location URL: https://archive-ouverte.unige.ch/unige:111733Citation Count: 162
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OPENTitle: A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood PressureJournal Name: The American Journal of Human GeneticsPublisher: Elsevier BVVol: 102Issue #: 3Start Page: 375End Page: 400Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.ajhg.2018.01.015Best OA location URL: http://www.cell.com/article/S000292971830017X/pdfCitation Count: 153
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OPENTitle: Isolating Visual and Proprioceptive Components of Motor Sequence Learning in ASDJournal Name: Autism ResearchPublisher: WileyVol: 9Issue #: 5Start Page: 563End Page: 569Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/aur.1537Best OA location URL: http://doi.org/10.1002/aur.1537Citation Count: 34
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OPENTitle: Olfactory identification in LRRK 2 G2019S mutation carriers: a relevant marker?Journal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 1Issue #: 9Start Page: 670End Page: 678Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.95Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.95Citation Count: 39
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OPENTitle: Targeting specific kinase substrates rescues increased colitis severity induced by the Crohn’s disease–linked LRRK2-N2081D variantJournal Name: Journal of Clinical InvestigationPublisher: American Society for Clinical InvestigationVol: 135Issue #: 19Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1172/jci190017Best OA location URL: https://doi.org/10.1172/jci190017Citation Count: 0
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OPENTitle: Understanding the Neurobiology of Cd200 and the Cd200 Receptor: A Therapeutic Target For Controlling Inflammation In Human Brains?Journal Name: Future NeurologyPublisher: Informa UK LimitedVol: 8Issue #: 3Start Page: 321End Page: 332Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.2217/fnl.13.14Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3815586Citation Count: 50
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OPENTitle: Acoustic Coordinated Reset Neuromodulation in a Real Life Patient Population with Chronic Tonal TinnitusJournal Name: BioMed Research InternationalPublisher: WileyVol: 2015Issue #:Start Page: 1End Page: 8Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1155/2015/569052Best OA location URL: https://downloads.hindawi.com/journals/bmri/2015/569052.pdfCitation Count: 24
- Enhanced histamine H2 excitation of striatal cholinergic interneurons in l-DOPA-induced dyskinesia2015OPENTitle: Enhanced histamine H2 excitation of striatal cholinergic interneurons in l-DOPA-induced dyskinesiaJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 76Issue #:Start Page: 67End Page: 76Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nbd.2015.01.003Best OA location URL: https://doi.org/10.1016/j.nbd.2015.01.003Citation Count: 43
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OPENTitle: The deterministic role of 5-mers in microRNA-gene targetingJournal Name: RNA BiologyPublisher: Informa UK LimitedVol:Issue #:Start Page: 1End Page: 7Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/15476286.2018.1462652Best OA location URL: https://www.tandfonline.com/doi/pdf/10.1080/15476286.2018.1462652?needAccess=trueCitation Count: 16
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OPENTitle: Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational effortsJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 140Issue #: 6Start Page: 1544End Page: 1547Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/awx107Best OA location URL: https://academic.oup.com/brain/article-pdf/140/6/1544/18186427/awx107.pdfCitation Count: 18
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OPENTitle: High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's diseaseJournal Name: Journal of Neuroscience MethodsPublisher: Elsevier BVVol: 261Issue #:Start Page: 117End Page: 127Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.jneumeth.2015.11.009Best OA location URL: http://linkinghub.elsevier.com/retrieve/pii/S0165-0270(15)00411-2Citation Count: 16
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OPENTitle: GBA mutations are associated with Rapid Eye Movement Sleep Behavior DisorderJournal Name: Annals of Clinical and Translational NeurologyPublisher: WileyVol: 2Issue #: 9Start Page: 941End Page: 945Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1002/acn3.228Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.228Citation Count: 137
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OPENTitle: Substantia nigra hyperechogenicity with LRRK2 G2019S mutationsJournal Name: Movement DisordersPublisher: WileyVol: 26Issue #: 5Start Page: 885End Page: 888Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.23644Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3082617Citation Count: 36
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OPENTitle: Benzoyl chloride derivatization with liquid chromatography–mass spectrometry for targeted metabolomics of neurochemicals in biological samplesJournal Name: Journal of Chromatography APublisher: Elsevier BVVol: 1446Issue #:Start Page: 78End Page: 90Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.chroma.2016.04.006Best OA location URL: http://doi.org/10.1016/j.chroma.2016.04.006Citation Count: 227
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OPENTitle: Predicting primary progressive aphasias with support vector machine approaches in structural MRI dataJournal Name: NeuroImage: ClinicalPublisher: Elsevier BVVol: 14Issue #:Start Page: 334End Page: 343Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nicl.2017.02.003Best OA location URL: https://doi.org/10.1016/j.nicl.2017.02.003Citation Count: 50
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OPENTitle: Over‐expression of an inactive mutant cathepsin D increases endogenous alpha‐synuclein and cathepsin B activity in SH‐SY5Y cellsJournal Name: Journal of NeurochemistryPublisher: WileyVol: 128Issue #: 6Start Page: 950End Page: 961Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/jnc.12497Best OA location URL: http://doi.org/10.1111/jnc.12497Citation Count: 38
- Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo2014OPENTitle: Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivoJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 137Issue #: 5Start Page: 1496End Page: 1513Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/awu057Best OA location URL: https://academic.oup.com/brain/article-pdf/137/5/1496/11140606/awu057.pdfCitation Count: 220
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OPENTitle: A comparative study of Lrrk2 function in primary neuronal culturesJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 16Issue #: 10Start Page: 650End Page: 655Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2010.08.018Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3159957Citation Count: 81
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OPENTitle: Metabotropic glutamate receptor 4 in the basal ganglia of parkinsonian monkeys: Ultrastructural localization and electrophysiological effects of activation in the striatopallidal complexJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 66Issue #:Start Page: 242End Page: 252Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2012.05.017Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3490034Citation Count: 41
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OPENTitle: The clinical significance of lower limb tremorsJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 65Issue #:Start Page: 165End Page: 171Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2019.06.007Best OA location URL: http://hdl.handle.net/20.500.11820/fcbc5316-6d53-418f-ba3a-a73208c6f186Citation Count: 13
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OPENTitle: Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharideJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 108Issue #:Start Page: 115End Page: 127Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2017.08.009Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5734673Citation Count: 63
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OPENTitle: Unraveling corticobasal syndrome and alien limb syndrome with structural brain imagingJournal Name: CortexPublisher: Elsevier BVVol: 117Issue #:Start Page: 33End Page: 40Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.cortex.2019.02.015Best OA location URL: https://doi.org/10.1016/j.cortex.2019.02.015Citation Count: 19
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OPENTitle: Alpha galactosidase A activity in Parkinson's diseaseJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 112Issue #:Start Page: 85End Page: 90Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2018.01.012Best OA location URL: https://doaj.org/article/2d3c35c920664143a7a6fbfadca77476Citation Count: 73
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OPENTitle: A Novel Lead Design for Modulation and Sensing of Deep Brain StructuresJournal Name: IEEE Transactions on Biomedical EngineeringPublisher: Institute of Electrical and Electronics Engineers (IEEE)Vol: 63Issue #: 1Start Page: 148End Page: 157Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1109/tbme.2015.2492921Best OA location URL: http://doi.org/10.1109/TBME.2015.2492921Citation Count: 38
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OPENTitle: Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrilsJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 129Issue #:Start Page: 67End Page: 78Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2019.05.012Best OA location URL: https://www.sciencedirect.com/science/article/pii/S096999611930124XCitation Count: 63
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OPENTitle: Dopamine transporter imaging for the diagnosis of multiple system atrophy cerebellar typeJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 63Issue #:Start Page: 199End Page: 203Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2019.02.006Best OA location URL: http://www.prd-journal.com/article/S1353802019300379/pdfCitation Count: 25
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OPENTitle: Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s DiseaseJournal Name: Cell ReportsPublisher: Elsevier BVVol: 22Issue #: 4Start Page: 930End Page: 940Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.celrep.2017.12.092Best OA location URL: http://www.cell.com/article/S2211124717319290/pdfCitation Count: 456
