1751 - 1800 of 6324 Results
Title
Year
- β‐amyloid and postural instability and gait difficulty in Parkinson's disease at risk for dementia2012OPENTitle: β‐amyloid and postural instability and gait difficulty in Parkinson's disease at risk for dementiaJournal Name: Movement DisordersPublisher: WileyVol: 28Issue #: 3Start Page: 296End Page: 301Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.25213Best OA location URL: https://hdl.handle.net/2027.42/97160Citation Count: 89
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OPENTitle: Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long termJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 135Issue #: 1Start Page: 65End Page: 83Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-017-1792-9Best OA location URL: https://link.springer.com/content/pdf/10.1007%2Fs00401-017-1792-9.pdfCitation Count: 184
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OPENTitle: Translation Initiator EIF4G1 Mutations in Familial Parkinson DiseaseJournal Name: The American Journal of Human GeneticsPublisher: Elsevier BVVol: 89Issue #: 3Start Page: 398End Page: 406Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.ajhg.2011.08.009Best OA location URL: http://www.cell.com/article/S0002929711003594/pdfCitation Count: 286
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OPENTitle: A Genome‐Wide Linkage Screen in the Amish with Parkinson Disease Points to Chromosome 6Journal Name: Annals of Human GeneticsPublisher: WileyVol: 75Issue #: 3Start Page: 351End Page: 358Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1469-1809.2011.00643.xBest OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1469-1809.2011.00643.xCitation Count: 10
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OPENTitle: Feasibility Study: Comparison of Frontal Cortex Needle Core Versus Open Biopsy for Detection of Characteristic Proteinopathies of Neurodegenerative DiseasesJournal Name: Journal of Neuropathology & Experimental NeurologyPublisher: Oxford University Press (OUP)Vol: 74Issue #: 9Start Page: 934End Page: 942Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1097/nen.0000000000000235Best OA location URL: https://academic.oup.com/jnen/article-pdf/74/9/934/8146595/74-9-934.pdfCitation Count: 13
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OPENTitle: Association of red cell distribution width with all-cause and cardiovascular-specific mortality in African American and white adults: a prospective cohort studyJournal Name: Journal of Translational MedicinePublisher: Springer Science and Business Media LLCVol: 15Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12967-017-1313-6Best OA location URL: https://translational-medicine.biomedcentral.com/track/pdf/10.1186/s12967-017-1313-6Citation Count: 27
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OPENTitle: Generation of Stable Transgenic C. elegans Using MicroinjectionJournal Name: Journal of Visualized ExperimentsPublisher: MyJove CorporationVol:Issue #: 18Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3791/833Best OA location URL: https://www.jove.com/pdf/833/generation-of-stable-transgenic-c-elegans-using-microinjectionCitation Count: 84
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OPENTitle: Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease GenesJournal Name: Journal of Visualized ExperimentsPublisher: MyJove CorporationVol:Issue #: 17Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3791/835Best OA location URL: https://www.jove.com/pdf/835/application-c-elegans-dopamine-neuron-degeneration-assay-forCitation Count: 46
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OPENTitle: Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed inXenopus laevisoocytesJournal Name: The Journal of PhysiologyPublisher: WileyVol: 586Issue #: 1Start Page: 227End Page: 245Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1113/jphysiol.2007.143172Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/2375544Citation Count: 97
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OPENTitle: Reliable Identification of Living Dopaminergic Neurons in Midbrain Cultures Using RNA Sequencing and TH-promoter-driven eGFP ExpressionJournal Name: Journal of Visualized ExperimentsPublisher: MyJove CorporationVol:Issue #: 120Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3791/54981Best OA location URL: https://www.jove.com/pdf/54981/reliable-identification-living-dopaminergic-neurons-midbrain-culturesCitation Count: 7
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OPENTitle: Host and Microbial Factors in Regulation of T Cells in the IntestineJournal Name: Frontiers in ImmunologyPublisher: Frontiers Media SAVol: 4Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fimmu.2013.00141Best OA location URL: https://www.frontiersin.org/articles/10.3389/fimmu.2013.00141/pdfCitation Count: 18
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OPENTitle: Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive PhosphateJournal Name: Journal of Visualized ExperimentsPublisher: MyJove CorporationVol:Issue #: 79Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3791/50523Best OA location URL: https://www.jove.com/pdf/50523/metabolic-labeling-leucine-rich-repeat-kinases-1-2-with-radioactiveCitation Count: 4
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OPENTitle: Detection of Protein UbiquitinationJournal Name: Journal of Visualized ExperimentsPublisher: MyJove CorporationVol:Issue #: 30Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3791/1293Best OA location URL: https://www.jove.com/pdf/1293/detection-of-protein-ubiquitinationCitation Count: 95
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OPENTitle: Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free AssaysJournal Name: Journal of Visualized ExperimentsPublisher: MyJove CorporationVol:Issue #: 126Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3791/55361Citation Count: 7
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OPENTitle: Subject-specific computational modeling of DBS in the PPTg areaJournal Name: Frontiers in Computational NeurosciencePublisher: Frontiers Media SAVol: 9Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fncom.2015.00093Best OA location URL: https://doi.org/10.3389/fncom.2015.00093Citation Count: 10
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OPENTitle: Neurogenic dysphagia with undigested macaroni and megaesophagus in familial dysautonomiaJournal Name: Clinical Autonomic ResearchPublisher: Springer Science and Business Media LLCVol: 28Issue #: 1Start Page: 125End Page: 126Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s10286-017-0487-6Citation Count: 12
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OPENTitle: MAPT haplotype diversity in multiple system atrophyJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 30Issue #:Start Page: 40End Page: 45Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2016.06.010Best OA location URL: http://doi.org/10.1016/j.parkreldis.2016.06.010Citation Count: 27
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OPENTitle: Lewy bodies in essential tremor are no different than in controlsJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 23Issue #:Start Page: 106End Page: 107Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2015.11.025Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5683710Citation Count: 7
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OPENTitle: Pantothenate kinase‐associated neurodegeneration is not a synucleinopathyJournal Name: Neuropathology and Applied NeurobiologyPublisher: WileyVol: 39Issue #: 2Start Page: 121End Page: 131Publication Date:Open Access(OA) Status: OPENLicense: unspecified-oaDOI - Digital Object Identifier: 10.1111/j.1365-2990.2012.01269.xBest OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2990.2012.01269.xCitation Count: 52
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OPENTitle: Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signalingJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 5Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep14125Best OA location URL: https://www.nature.com/articles/srep14125.pdfCitation Count: 38
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OPENTitle: Long-term Transgene Expression in the Central Nervous System Using DNA NanoparticlesJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 17Issue #: 4Start Page: 641End Page: 650Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/mt.2009.2Best OA location URL: https://doi.org/10.1038/mt.2009.2Citation Count: 77
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OPENTitle: Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tauJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 44Issue #: 1Start Page: 222End Page: 223Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41386-018-0204-8Best OA location URL: https://www.nature.com/articles/s41386-018-0204-8.pdfCitation Count: 1
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OPENTitle: Dopaminergic Lesions of the Dorsolateral Striatum in Rats Increase Delay Discounting in an Impulsive Choice TaskJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 10Issue #: 4Start Page: e0122063End Page: e0122063Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0122063Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0122063&type=printableCitation Count: 57
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OPENTitle: A Tangled Web – Tau and Sporadic Parkinson's DiseaseJournal Name: Frontiers in PsychiatryPublisher: Frontiers Media SAVol: 1Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fpsyt.2010.00150Best OA location URL: https://www.frontiersin.org/articles/10.3389/fpsyt.2010.00150/pdfCitation Count: 32
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OPENTitle: Automatic segmentation of the hippocampus for preterm neonates from early-in-life to term-equivalent ageJournal Name: NeuroImage: ClinicalPublisher: Elsevier BVVol: 9Issue #:Start Page: 176End Page: 193Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nicl.2015.07.019Best OA location URL: https://doi.org/10.1016/j.nicl.2015.07.019Citation Count: 38
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OPENTitle: Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non‐human primate after overexpression of GDNFJournal Name: Journal of Comparative NeurologyPublisher: WileyVol: 515Issue #: 1Start Page: 31End Page: 40Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/cne.22028Best OA location URL: http://doi.org/10.1002/cne.22028Citation Count: 40
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OPENTitle: Estrogen Receptor α Variants Affect Age at Onset of Alzheimer's Disease in a Multiethnic Female CohortJournal Name: Dementia and Geriatric Cognitive DisordersPublisher: S. Karger AGVol: 38Issue #: 3-4Start Page: 200End Page: 213Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1159/000355559Best OA location URL: https://karger.com/dem/article-pdf/38/3-4/200/2570057/000355559.pdfCitation Count: 25
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OPENTitle: Olfactory dysfunction in LRRK2 G2019S mutation carriersJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 77Issue #: 4Start Page: 319End Page: 324Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318227041cBest OA location URL: https://n.neurology.org/content/neurology/77/4/319.full.pdfCitation Count: 62
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OPENTitle: Pharmacologically distinct pramipexole-mediated akinesia vs. risk-taking in a rat model of Parkinson's diseaseJournal Name: Progress in Neuro-Psychopharmacology and Biological PsychiatryPublisher: Elsevier BVVol: 70Issue #:Start Page: 77End Page: 84Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.pnpbp.2016.05.004Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5410378Citation Count: 25
- Use, maintenance and dose effects of cognitive speed of processing training in Parkinson's disease2016OPENTitle: Use, maintenance and dose effects of cognitive speed of processing training in Parkinson's diseaseJournal Name: International Journal of NeurosciencePublisher: Informa UK LimitedVol: 127Issue #: 10Start Page: 841End Page: 848Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/00207454.2016.1269088Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8284743Citation Count: 9
- Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research2012OPENTitle: Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease ResearchJournal Name: PLoS ONEPublisher: Public Library of Science (PLoS)Vol: 7Issue #: 8Start Page: e43099End Page: e43099Publication Date:Open Access(OA) Status: OPENLicense: cc0DOI - Digital Object Identifier: 10.1371/journal.pone.0043099Best OA location URL: https://escholarship.org/uc/item/0hr9m7btCitation Count: 138
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OPENTitle: Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factorJournal Name: NeurosciencePublisher: Elsevier BVVol: 194Issue #:Start Page: 220End Page: 226Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuroscience.2011.07.072Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3408714Citation Count: 34
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OPENTitle: Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s diseaseJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-33921-xBest OA location URL: https://www.nature.com/articles/s41598-018-33921-x.pdfCitation Count: 104
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OPENTitle: Evaluation of Parkinson Disease Risk Variants as Expression-QTLsJournal Name: PLoS ONEPublisher: Public Library of Science (PLoS)Vol: 7Issue #: 10Start Page: e46199End Page: e46199Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0046199Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046199&type=printableCitation Count: 43
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OPENTitle: A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnoverJournal Name: Nature CommunicationsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41467-017-01103-4Best OA location URL: https://pub.dzne.de/record/139567Citation Count: 469
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OPENTitle: The Identification of Alpha-Synuclein as the First Parkinson Disease GeneJournal Name: Journal of Parkinson’s DiseasePublisher: SAGE PublicationsVol: 7Issue #: s1Start Page: S43End Page: S49Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.3233/jpd-179003Best OA location URL: https://content.iospress.com:443/download/journal-of-parkinsons-disease/jpd179003?id=journal-of-parkinsons-disease%2Fjpd179003Citation Count: 67
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OPENTitle: Antidepressant potential of metabotropic glutamate receptor mGlu2 and mGlu3 negative allosteric modulatorsJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 44Issue #: 1Start Page: 214End Page: 236Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41386-018-0192-8Best OA location URL: https://www.nature.com/articles/s41386-018-0192-8.pdfCitation Count: 17
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OPENTitle: Intake of antioxidant vitamins and risk of Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 31Issue #: 12Start Page: 1909End Page: 1914Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.26819Best OA location URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41263027Citation Count: 102
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OPENTitle: Pesticides that inhibit the ubiquitin–proteasome system: Effect measure modification by genetic variation in SKP1 in Parkinson׳s diseaseJournal Name: Environmental ResearchPublisher: Elsevier BVVol: 126Issue #:Start Page: 1End Page: 8Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.envres.2013.08.001Best OA location URL: http://doi.org/10.1016/j.envres.2013.08.001Citation Count: 48
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OPENTitle: Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase ParkinJournal Name: PLoS Computational BiologyPublisher: Public Library of Science (PLoS)Vol: 10Issue #: 11Start Page: e1003935End Page: e1003935Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pcbi.1003935Best OA location URL: https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003935&type=printableCitation Count: 109
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OPENTitle: Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase InhibitionJournal Name: Molecular NeurobiologyPublisher: Springer Science and Business Media LLCVol: 53Issue #: 8Start Page: 5161End Page: 5177Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s12035-015-9435-4Best OA location URL: https://link.springer.com/content/pdf/10.1007/s12035-015-9435-4.pdfCitation Count: 63
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OPENTitle: Apathy and Depression: Separate Factors in Parkinson's DiseaseJournal Name: Journal of the International Neuropsychological SocietyPublisher: Cambridge University Press (CUP)Vol: 17Issue #: 6Start Page: 1058End Page: 1066Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1017/s1355617711001068Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3302577Citation Count: 131
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OPENTitle: Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γAgonist against MPTPJournal Name: PPAR ResearchPublisher: WileyVol: 2013Issue #:Start Page: 1End Page: 16Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1155/2013/582809Best OA location URL: https://downloads.hindawi.com/journals/ppar/2013/582809.pdfCitation Count: 28
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OPENTitle: Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic ProteinsJournal Name: Methods in Molecular BiologyPublisher: Springer New YorkVol:Issue #:Start Page: 369End Page: 386Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/978-1-4939-7811-3_24Citation Count: 17
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OPENTitle: Sensitivity and specificity of the finger tapping task for the detection of psychogenic movement disordersJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 16Issue #: 3Start Page: 197End Page: 201Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2009.11.007Citation Count: 30
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OPENTitle: Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal FluidJournal Name: NeurotherapeuticsPublisher: Elsevier BVVol: 13Issue #: 1Start Page: 217End Page: 225Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s13311-015-0404-4Best OA location URL: http://doi.org/10.1007/s13311-015-0404-4Citation Count: 38
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OPENTitle: Pre- and Post- GPi DBS Neuropsychological Profiles in a Case of X-Linked Dystonia-ParkinsonismJournal Name: The Clinical NeuropsychologistPublisher: Informa UK LimitedVol: 25Issue #: 1Start Page: 141End Page: 159Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/13854046.2010.532812Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3070298Citation Count: 8
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OPENTitle: Exonic Re-Sequencing of the Chromosome 2q24.3 Parkinson’s Disease LocusJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 10Issue #: 6Start Page: e0128586End Page: e0128586Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0128586Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0128586&type=printableCitation Count: 1
- The Safety of Using Body-Transmit MRI in Patients with Implanted Deep Brain Stimulation Devices2015OPENTitle: The Safety of Using Body-Transmit MRI in Patients with Implanted Deep Brain Stimulation DevicesJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 10Issue #: 6Start Page: e0129077End Page: e0129077Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0129077Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0129077&type=printableCitation Count: 55
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OPENTitle: Functional Role of the Disulfide Isomerase ERp57 in Axonal RegenerationJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 10Issue #: 9Start Page: e0136620End Page: e0136620Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0136620Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0136620&type=printableCitation Count: 54