2451 - 2500 of 6516 Results
Title
Year
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OPENTitle: MKK6 binds and regulates expression of Parkinson’s disease‐related protein LRRK2Journal Name: Journal of NeurochemistryPublisher: WileyVol: 112Issue #: 6Start Page: 1593End Page: 1604Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1471-4159.2010.06568.xBest OA location URL: http://doi.org/10.1111/j.1471-4159.2010.06568.xCitation Count: 101
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OPENTitle: Association of Parkinson Disease with Structural and Regulatory Variants in the HLA RegionJournal Name: The American Journal of Human GeneticsPublisher: Elsevier BVVol: 93Issue #: 5Start Page: 984End Page: 993Publication Date:Open Access(OA) Status: OPENLicense: publisher-specific-oaDOI - Digital Object Identifier: 10.1016/j.ajhg.2013.10.009Best OA location URL: http://www.cell.com/article/S0002929713004667/pdfCitation Count: 167
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OPENTitle: Lentiviral Overexpression of GRK6 Alleviates l -Dopa–Induced Dyskinesia in Experimental Parkinson’s DiseaseJournal Name: Science Translational MedicinePublisher: American Association for the Advancement of Science (AAAS)Vol: 2Issue #: 28Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1126/scitranslmed.3000664Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/2933751Citation Count: 135
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OPENTitle: Ser(P)‐1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 31Issue #: 10Start Page: 1543End Page: 1550Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.26686Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5053851Citation Count: 181
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OPENTitle: Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neuronsJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1750-1326-4-34Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-4-34Citation Count: 90
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OPENTitle: Pantothenate kinase‐associated neurodegeneration is not a synucleinopathyJournal Name: Neuropathology and Applied NeurobiologyPublisher: WileyVol: 39Issue #: 2Start Page: 121End Page: 131Publication Date:Open Access(OA) Status: OPENLicense: unspecified-oaDOI - Digital Object Identifier: 10.1111/j.1365-2990.2012.01269.xBest OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2990.2012.01269.xCitation Count: 52
- Neurogenic dysphagia with undigested macaroni and megaesophagus in familial dysautonomia2017OPENTitle: Neurogenic dysphagia with undigested macaroni and megaesophagus in familial dysautonomiaJournal Name: Clinical Autonomic ResearchPublisher: Springer Science and Business Media LLCVol: 28Issue #: 1Start Page: 125End Page: 126Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s10286-017-0487-6Citation Count: 12
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OPENTitle: MAPT haplotype diversity in multiple system atrophyJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 30Issue #:Start Page: 40End Page: 45Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2016.06.010Best OA location URL: http://doi.org/10.1016/j.parkreldis.2016.06.010Citation Count: 27
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OPENTitle: Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signalingJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 5Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/srep14125Best OA location URL: https://www.nature.com/articles/srep14125.pdfCitation Count: 38
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OPENTitle: Lewy bodies in essential tremor are no different than in controlsJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 23Issue #:Start Page: 106End Page: 107Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.parkreldis.2015.11.025Best OA location URL: http://doi.org/10.1016/j.parkreldis.2015.11.025Citation Count: 7
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OPENTitle: Long-term Transgene Expression in the Central Nervous System Using DNA NanoparticlesJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 17Issue #: 4Start Page: 641End Page: 650Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/mt.2009.2Best OA location URL: http://www.cell.com/article/S152500161631557X/pdfCitation Count: 77
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OPENTitle: Automatic segmentation of the hippocampus for preterm neonates from early-in-life to term-equivalent ageJournal Name: NeuroImage: ClinicalPublisher: Elsevier BVVol: 9Issue #:Start Page: 176End Page: 193Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.nicl.2015.07.019Best OA location URL: https://doi.org/10.1016/j.nicl.2015.07.019Citation Count: 38
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OPENTitle: Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tauJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 44Issue #: 1Start Page: 222End Page: 223Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41386-018-0204-8Best OA location URL: https://www.nature.com/articles/s41386-018-0204-8.pdfCitation Count: 1
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OPENTitle: Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non‐human primate after overexpression of GDNFJournal Name: Journal of Comparative NeurologyPublisher: WileyVol: 515Issue #: 1Start Page: 31End Page: 40Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/cne.22028Best OA location URL: http://doi.org/10.1002/cne.22028Citation Count: 40
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OPENTitle: Estrogen Receptor α Variants Affect Age at Onset of Alzheimer's Disease in a Multiethnic Female CohortJournal Name: Dementia and Geriatric Cognitive DisordersPublisher: S. Karger AGVol: 38Issue #: 3-4Start Page: 200End Page: 213Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1159/000355559Best OA location URL: https://karger.com/dem/article-pdf/38/3-4/200/2570057/000355559.pdfCitation Count: 25
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OPENTitle: Olfactory dysfunction in LRRK2 G2019S mutation carriersJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 77Issue #: 4Start Page: 319End Page: 324Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318227041cBest OA location URL: https://n.neurology.org/content/neurology/77/4/319.full.pdfCitation Count: 62
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OPENTitle: Chipping away at diagnostics for neurodegenerative diseasesJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 35Issue #: 2Start Page: 148End Page: 156Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2009.02.016Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/2753504Citation Count: 20
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OPENTitle: Pharmacologically distinct pramipexole-mediated akinesia vs. risk-taking in a rat model of Parkinson's diseaseJournal Name: Progress in Neuro-Psychopharmacology and Biological PsychiatryPublisher: Elsevier BVVol: 70Issue #:Start Page: 77End Page: 84Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.pnpbp.2016.05.004Best OA location URL: http://doi.org/10.1016/j.pnpbp.2016.05.004Citation Count: 25
- Use, maintenance and dose effects of cognitive speed of processing training in Parkinson's disease2016OPENTitle: Use, maintenance and dose effects of cognitive speed of processing training in Parkinson's diseaseJournal Name: International Journal of NeurosciencePublisher: Informa UK LimitedVol: 127Issue #: 10Start Page: 841End Page: 848Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1080/00207454.2016.1269088Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/8284743Citation Count: 9
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OPENTitle: Evaluation of Parkinson Disease Risk Variants as Expression-QTLsJournal Name: PLoS ONEPublisher: Public Library of Science (PLoS)Vol: 7Issue #: 10Start Page: e46199End Page: e46199Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0046199Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046199&type=printableCitation Count: 43
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OPENTitle: The Identification of Alpha-Synuclein as the First Parkinson Disease GeneJournal Name: Journal of Parkinson’s DiseasePublisher: SAGE PublicationsVol: 7Issue #: s1Start Page: S43End Page: S49Publication Date:Open Access(OA) Status: OPENLicense: cc-by-ncDOI - Digital Object Identifier: 10.3233/jpd-179003Best OA location URL: https://content.iospress.com:443/download/journal-of-parkinsons-disease/jpd179003?id=journal-of-parkinsons-disease%2Fjpd179003Citation Count: 67
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OPENTitle: Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factorJournal Name: NeurosciencePublisher: Elsevier BVVol: 194Issue #:Start Page: 220End Page: 226Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuroscience.2011.07.072Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3408714Citation Count: 34
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OPENTitle: Antidepressant potential of metabotropic glutamate receptor mGlu2 and mGlu3 negative allosteric modulatorsJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 44Issue #: 1Start Page: 214End Page: 236Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41386-018-0192-8Best OA location URL: https://www.nature.com/articles/s41386-018-0192-8.pdfCitation Count: 17
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OPENTitle: Intake of antioxidant vitamins and risk of Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 31Issue #: 12Start Page: 1909End Page: 1914Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.26819Best OA location URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41263027Citation Count: 102
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OPENTitle: Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutationsJournal Name: AutophagyPublisher: Informa UK LimitedVol: 15Issue #: 1Start Page: 113End Page: 130Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1080/15548627.2018.1509818Best OA location URL: https://www.tandfonline.com/doi/pdf/10.1080/15548627.2018.1509818?needAccess=trueCitation Count: 197
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OPENTitle: Impact of Alzheimer's Disease, Lewy Body and Vascular Co-Pathologies on Clinical Transition to Dementia in a National Autopsy CohortJournal Name: Dementia and Geriatric Cognitive DisordersPublisher: S. Karger AGVol: 42Issue #: 1-2Start Page: 106End Page: 116Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1159/000448243Best OA location URL: http://doi.org/10.1159/000448243Citation Count: 18
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OPENTitle: Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycleJournal Name: Biochemical JournalPublisher: Portland Press Ltd.Vol: 456Issue #: 1Start Page: 119End Page: 128Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1042/bj20121772Best OA location URL: http://doi.org/10.1042/BJ20121772Citation Count: 94
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OPENTitle: Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase InhibitionJournal Name: Molecular NeurobiologyPublisher: Springer Science and Business Media LLCVol: 53Issue #: 8Start Page: 5161End Page: 5177Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s12035-015-9435-4Best OA location URL: https://link.springer.com/content/pdf/10.1007/s12035-015-9435-4.pdfCitation Count: 63
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OPENTitle: Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cellsJournal Name: Nature CommunicationsPublisher: Springer Science and Business Media LLCVol: 3Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/ncomms1669Best OA location URL: https://www.nature.com/articles/ncomms1669.pdfCitation Count: 243
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OPENTitle: Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization databaseJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page: 6End Page: 6Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1750-1326-4-6Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-4-6Citation Count: 10
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OPENTitle: Non-radioactive in vitro PINK1 Kinase Assays Using Ubiquitin or Parkin as SubstrateJournal Name: BIO-PROTOCOLPublisher: Bio-Protocol, LLCVol: 6Issue #: 19Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.21769/bioprotoc.1946Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5448420Citation Count: 6
- Hormesis2012OPENTitle: HormesisJournal Name: AutophagyPublisher: Informa UK LimitedVol: 8Issue #: 6Start Page: 997End Page: 1001Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.4161/auto.20748Best OA location URL: https://www.tandfonline.com/doi/pdf/10.4161/auto.20748?needAccess=trueCitation Count: 66
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OPENTitle: Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian miceJournal Name: Journal of Clinical InvestigationPublisher: American Society for Clinical InvestigationVol: 118Issue #: 1Start Page: 149End Page: 160Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1172/jci32273Best OA location URL: http://doi.org/10.1172/JCI32273Citation Count: 179
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OPENTitle: A screening tool to detect clinical manganese neurotoxicityJournal Name: NeuroToxicologyPublisher: Elsevier BVVol: 64Issue #:Start Page: 12End Page: 18Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuro.2017.02.009Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5587364Citation Count: 6
- Failure of Sequential Pallidal and Motor Thalamus DBS for Rapid‐Onset Dystonia‐Parkinsonism (DYT12)2017OPENTitle: Failure of Sequential Pallidal and Motor Thalamus DBS for Rapid‐Onset Dystonia‐Parkinsonism (DYT12)Journal Name: Movement Disorders Clinical PracticePublisher: WileyVol: 5Issue #: 4Start Page: 444End Page: 445Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mdc3.12559Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.12559Citation Count: 11
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OPENTitle: Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate BrainJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 18Issue #: 3Start Page: 588End Page: 593Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/mt.2009.286Best OA location URL: http://www.cell.com/article/S1525001616323085/pdfCitation Count: 127
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OPENTitle: Functional Neuroprotection and Efficient Regulation of GDNF Using Destabilizing Domains in a Rodent Model of Parkinson’s DiseaseJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 21Issue #: 12Start Page: 2169End Page: 2180Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/mt.2013.169Best OA location URL: http://www.cell.com/article/S1525001616309431/pdfCitation Count: 55
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OPENTitle: Striatal Pleiotrophin Overexpression Provides Functional and Morphological Neuroprotection in the 6-Hydroxydopamine ModelJournal Name: Molecular TherapyPublisher: Elsevier BVVol: 20Issue #: 3Start Page: 544End Page: 554Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/mt.2011.216Best OA location URL: http://www.cell.com/article/S1525001616305111/pdfCitation Count: 31
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OPENTitle: The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activityJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 12Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13024-017-0174-zBest OA location URL: https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-017-0174-zCitation Count: 76
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OPENTitle: Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathologyJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 54Issue #:Start Page: 175End Page: 186Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2017.03.007Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5862548Citation Count: 31
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OPENTitle: Analysis of COQ2gene in multiple system atrophyJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 9Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1750-1326-9-44Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/counter/pdf/10.1186/1750-1326-9-44Citation Count: 45
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OPENTitle: Multiple system atrophy is not caused by C9orf72 hexanucleotide repeat expansionsJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 36Issue #: 2Start Page: 1223.e1End Page: 1223.e2Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2014.08.033Best OA location URL: http://doi.org/10.1016/j.neurobiolaging.2014.08.033Citation Count: 30
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OPENTitle: Pathophysiology of manganese-associated neurotoxicityJournal Name: NeuroToxicologyPublisher: Elsevier BVVol: 33Issue #: 4Start Page: 881End Page: 886Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuro.2011.12.010Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3350837Citation Count: 129
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OPENTitle: The timing and amount of vagus nerve stimulation during rehabilitative training affect poststroke recovery of forelimb strengthJournal Name: NeuroReportPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 25Issue #: 9Start Page: 676End Page: 682Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1097/wnr.0000000000000154Best OA location URL: http://doi.org/10.1097/WNR.0000000000000154Citation Count: 105
- Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's disease2009OPENTitle: Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's diseaseJournal Name: Neuroscience LettersPublisher: Elsevier BVVol: 452Issue #: 3Start Page: 277End Page: 280Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neulet.2009.01.071Best OA location URL: http://doi.org/10.1016/j.neulet.2009.01.071Citation Count: 34
- Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration2013OPENTitle: Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administrationJournal Name: Neuroscience LettersPublisher: Elsevier BVVol: 538Issue #:Start Page: 3End Page: 8Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neulet.2013.01.035Citation Count: 10
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OPENTitle: Histone H3 acetylation in the postmortem Parkinson’s disease primary motor cortexJournal Name: Neuroscience LettersPublisher: Elsevier BVVol: 627Issue #:Start Page: 121End Page: 125Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neulet.2016.05.060Best OA location URL: http://doi.org/10.1016/j.neulet.2016.05.060Citation Count: 55
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OPENTitle: Evaluation of D2 and D3 dopamine receptor selective compounds on l-dopa-dependent abnormal involuntary movements in ratsJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 56Issue #: 6-7Start Page: 956End Page: 969Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2009.01.019Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4106465Citation Count: 53
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OPENTitle: Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsyJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 136Issue #: 5Start Page: 709End Page: 727Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-018-1900-5Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00401-018-1900-5.pdfCitation Count: 59
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OPENTitle: Extracellular vesicle sorting of α-Synuclein is regulated by sumoylationJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 129Issue #: 5Start Page: 695End Page: 713Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-015-1408-1Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00401-015-1408-1.pdfCitation Count: 158