3951 - 4000 of 6420 Results
Title
Year
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OPENTitle: Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson’s diseaseJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 12Issue #: 9Start Page: e0184117End Page: e0184117Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0184117Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184117&type=printableCitation Count: 17
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OPENTitle: MAPT p.V363I mutationJournal Name: Neurology GeneticsPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 5Issue #: 4Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1212/nxg.0000000000000347Best OA location URL: https://ng.neurology.org/content/nng/5/4/e347.full.pdfCitation Count: 13
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OPENTitle: Genetic risk of Parkinson disease and progression:Journal Name: Neurology GeneticsPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 5Issue #: 4Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1212/nxg.0000000000000348Best OA location URL: https://ng.neurology.org/content/nng/5/4/e348.full.pdfCitation Count: 148
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OPENTitle: Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysisJournal Name: Nature NeurosciencePublisher: Springer Science and Business Media LLCVol: 22Issue #: 8Start Page: 1248End Page: 1257Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41593-019-0457-5Citation Count: 242
- Characterization of oromotor and limb motor dysfunction in the DJ1 -/- model of Parkinson disease2017OPENTitle: Characterization of oromotor and limb motor dysfunction in the DJ1 -/- model of Parkinson diseaseJournal Name: Behavioural Brain ResearchPublisher: Elsevier BVVol: 339Issue #:Start Page: 47End Page: 56Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.bbr.2017.10.036Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5729095Citation Count: 22
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OPENTitle: Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeysJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-24362-7Best OA location URL: https://www.nature.com/articles/s41598-018-24362-7.pdfCitation Count: 29
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OPENTitle: Neuroimaging Analysis of the Dopamine Basis for Apathetic Behaviors in an MPTP-Lesioned Primate ModelJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 10Issue #: 7Start Page: e0132064End Page: e0132064Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0132064Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0132064&type=printableCitation Count: 25
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OPENTitle: Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic developmentJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 10Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41598-020-63559-7Best OA location URL: https://www.nature.com/articles/s41598-020-63559-7.pdfCitation Count: 60
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OPENTitle: Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokinesJournal Name: Science AdvancesPublisher: American Association for the Advancement of Science (AAAS)Vol: 9Issue #: 16Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1126/sciadv.ade1282Best OA location URL: https://doi.org/10.1126/sciadv.ade1282Citation Count: 32
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OPENTitle: Structure of LRRK1 and mechanisms of autoinhibition and activationJournal Name: Nature Structural & Molecular BiologyPublisher: Springer Science and Business Media LLCVol: 30Issue #: 11Start Page: 1735End Page: 1745Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41594-023-01109-1Best OA location URL: https://www.nature.com/articles/s41594-023-01109-1.pdfCitation Count: 7
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OPENTitle: TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse modelsJournal Name: Nature NeurosciencePublisher: Springer Science and Business Media LLCVol: 27Issue #: 5Start Page: 873End Page: 885Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41593-024-01610-wBest OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/11102654Citation Count: 23
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OPENTitle: From a deep learning model back to the brain—Identifying regional predictors and their relation to agingJournal Name: Human Brain MappingPublisher: WileyVol: 41Issue #: 12Start Page: 3235End Page: 3252Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc, cc-by-ncDOI - Digital Object Identifier: 10.1002/hbm.25011Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25011Citation Count: 87
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OPENTitle: MAPT haplotype–stratified GWAS reveals differential association for AD risk variantsJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 16Issue #: 7Start Page: 983End Page: 1002Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-by, cc-byDOI - Digital Object Identifier: 10.1002/alz.12099Best OA location URL: https://doi.org/10.1002/alz.12099Citation Count: 37
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OPENTitle: In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contactsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 119Issue #: 29Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-by, cc-byDOI - Digital Object Identifier: 10.1073/pnas.2203769119Best OA location URL: https://doi.org/10.1073/pnas.2203769119Citation Count: 62
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OPENTitle: Deficiency of the frontotemporal dementia gene GRN results in gangliosidosisJournal Name: Nature CommunicationsPublisher: Springer Science and Business Media LLCVol: 13Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41467-022-33500-9Best OA location URL: https://www.nature.com/articles/s41467-022-33500-9.pdfCitation Count: 73
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OPENTitle: New insights into the genetic etiology of Alzheimer’s disease and related dementiasJournal Name: Nature GeneticsPublisher: Springer Science and Business Media LLCVol: 54Issue #: 4Start Page: 412End Page: 436Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41588-022-01024-zBest OA location URL: https://www.nature.com/articles/s41588-022-01024-z.pdfCitation Count: 1694
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OPENTitle: Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson’s diseaseJournal Name: Nature CommunicationsPublisher: Springer Science and Business Media LLCVol: 14Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41467-023-39652-6Best OA location URL: https://www.nature.com/articles/s41467-023-39652-6.pdfCitation Count: 28
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OPENTitle: Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubulesJournal Name: Nature Structural & Molecular BiologyPublisher: Springer Science and Business Media LLCVol: 29Issue #: 12Start Page: 1196End Page: 1207Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41594-022-00863-yBest OA location URL: https://www.nature.com/articles/s41594-022-00863-y.pdfCitation Count: 47
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OPENTitle: Structure of LRRK2 in Parkinson’s disease and model for microtubule interactionJournal Name: NaturePublisher: Springer Science and Business Media LLCVol: 588Issue #: 7837Start Page: 344End Page: 349Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41586-020-2673-2Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/7726071Citation Count: 203
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OPENTitle: Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9Journal Name: NeuronPublisher: Elsevier BVVol: 110Issue #: 5Start Page: 824End Page: 840.e10Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-nd, cc-by-nc-nd, cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.neuron.2021.12.031Best OA location URL: http://www.cell.com/article/S089662732101076X/pdfCitation Count: 81
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OPENTitle: Loss of SYNJ1 dual phosphatase activity leads to early onset refractory seizures and progressive neurological declineJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 139Issue #: 9Start Page: 2420End Page: 2430Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/aww180Best OA location URL: https://academic.oup.com/brain/article-pdf/139/9/2420/17944760/aww180.pdfCitation Count: 77
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OPENTitle: Remote smartphone monitoring of Parkinson’s disease and individual response to therapyJournal Name: Nature BiotechnologyPublisher: Springer Science and Business Media LLCVol: 40Issue #: 4Start Page: 480End Page: 487Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41587-021-00974-9Best OA location URL: http://hdl.handle.net/2066/252104Citation Count: 117
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OPENTitle: Brain-restricted mTOR inhibition with binary pharmacologyJournal Name: NaturePublisher: Springer Science and Business Media LLCVol: 609Issue #: 7928Start Page: 822End Page: 828Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41586-022-05213-yBest OA location URL: https://www.nature.com/articles/s41586-022-05213-y.pdfCitation Count: 60
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OPENTitle: A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s diseaseJournal Name: Nature MedicinePublisher: Springer Science and Business Media LLCVol: 31Issue #: 5Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-nd, cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/s41591-025-03565-2Best OA location URL: https://www.nature.com/articles/s41591-025-03565-2.pdfCitation Count: 19
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OPENTitle: Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusionsJournal Name: NeuronPublisher: Elsevier BVVol: 112Issue #: 17Start Page: 2886End Page: 2909.e16Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-by, cc-byDOI - Digital Object Identifier: 10.1016/j.neuron.2024.06.002Best OA location URL: http://www.cell.com/article/S0896627324004094/pdfCitation Count: 12
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OPENTitle: Genetic variants and functional pathways associated with resilience to Alzheimer’s diseaseJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 143Issue #: 8Start Page: 2561End Page: 2575Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc, cc-by-ncDOI - Digital Object Identifier: 10.1093/brain/awaa209Best OA location URL: https://academic.oup.com/brain/article-pdf/143/8/2561/37356057/awaa209.pdfCitation Count: 126
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OPENTitle: A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1Journal Name: CellPublisher: Elsevier BVVol: 154Issue #: 4Start Page: 737End Page: 747Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.cell.2013.07.030Best OA location URL: http://www.cell.com/article/S009286741300901X/pdfCitation Count: 252
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OPENTitle: From policy to practice: Lessons learned from an open science funding initiativeJournal Name: PLOS Computational BiologyPublisher: Public Library of Science (PLoS)Vol: 19Issue #: 12Start Page: e1011626End Page: e1011626Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1371/journal.pcbi.1011626Best OA location URL: https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011626&type=printableCitation Count: 3
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OPENTitle: Use of Glycolysis‐Enhancing Drugs and Risk of Parkinson's DiseaseJournal Name: Movement DisordersPublisher: WileyVol: 37Issue #: 11Start Page: 2210End Page: 2216Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1002/mds.29184Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.29184Citation Count: 23
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OPENTitle: A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 78Issue #: 16Start Page: 1229End Page: 1236Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e3182516244Best OA location URL: https://n.neurology.org/content/neurology/78/16/1229.full.pdfCitation Count: 325
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OPENTitle: α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicityJournal Name: Nature GeneticsPublisher: Springer Science and Business Media LLCVol: 41Issue #: 3Start Page: 308End Page: 315Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/ng.300Best OA location URL: http://doi.org/10.1038/ng.300Citation Count: 527
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OPENTitle: The unfolded protein response is activated in the olfactory system in Alzheimer’s diseaseJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1186/s40478-020-00986-7Best OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-020-00986-7Citation Count: 37
- Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity2005OPENTitle: Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicityJournal Name: BMC NeurosciencePublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1186/1471-2202-6-71Best OA location URL: https://bmcneurosci.biomedcentral.com/counter/pdf/10.1186/1471-2202-6-71Citation Count: 66
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OPENTitle: Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP BiosensorJournal Name: Molecular PharmacologyPublisher: Elsevier BVVol: 74Issue #: 3Start Page: 585End Page: 594Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1124/mol.108.048884Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3766527Citation Count: 149
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OPENTitle: EndoMAP.v1 charts the structural landscape of human early endosome complexesJournal Name: NaturePublisher: Springer Science and Business Media LLCVol: 643Issue #: 8070Start Page: 252End Page: 261Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s41586-025-09059-yBest OA location URL: https://www.nature.com/articles/s41586-025-09059-y.pdfCitation Count: 0
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OPENTitle: Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2Journal Name: Science AdvancesPublisher: American Association for the Advancement of Science (AAAS)Vol: 11Issue #: 23Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1126/sciadv.adt2050Best OA location URL: https://doi.org/10.1126/sciadv.adt2050Citation Count: 0
- BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response2011OPENTitle: BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein responseJournal Name: The EMBO JournalPublisher: Springer Science and Business Media LLCVol: 30Issue #: 21Start Page: 4465End Page: 4478Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/emboj.2011.318Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/emboj.2011.318Citation Count: 112
- Stochastic electrotransport selectively enhances the transport of highly electromobile molecules2015OPENTitle: Stochastic electrotransport selectively enhances the transport of highly electromobile moleculesJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 112Issue #: 46Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1510133112Best OA location URL: https://www.pnas.org/content/pnas/112/46/E6274.full.pdfCitation Count: 237
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OPENTitle: Phosphoglycerate kinase is a central leverage point in Parkinson’s disease–driven neuronal metabolic deficitsJournal Name: Science AdvancesPublisher: American Association for the Advancement of Science (AAAS)Vol: 10Issue #: 34Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1126/sciadv.adn6016Best OA location URL: https://doi.org/10.1126/sciadv.adn6016Citation Count: 8
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OPENTitle: Triglycerides are an important fuel reserve for synapse function in the brainJournal Name: Nature MetabolismPublisher: Springer Science and Business Media LLCVol: 7Issue #: 7Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1038/s42255-025-01321-xBest OA location URL: https://www.nature.com/articles/s42255-025-01321-x.pdfCitation Count: 0
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OPENTitle: Pitx3 is required for development of substantia nigra dopaminergic neuronsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 100Issue #: 7Start Page: 4245End Page: 4250Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0230529100Best OA location URL: http://doi.org/10.1073/pnas.0230529100Citation Count: 382
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OPENTitle: JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degenerationJournal Name: Journal of NeurochemistryPublisher: WileyVol: 107Issue #: 6Start Page: 1578End Page: 1588Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1471-4159.2008.05713.xBest OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2008.05713.x?download=trueCitation Count: 79
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OPENTitle: Regulation of Physiologic Actions of LRRK2: Focus on AutophagyJournal Name: Neurodegenerative DiseasesPublisher: S. Karger AGVol: 10Issue #: 1-4Start Page: 238End Page: 241Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1159/000332599Best OA location URL: https://www.karger.com/Article/Pdf/332599Citation Count: 39
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OPENTitle: Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tauJournal Name: Journal of Clinical InvestigationPublisher: American Society for Clinical InvestigationVol: 125Issue #: 2Start Page: 681End Page: 686Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1172/jci78421Best OA location URL: http://doi.org/10.1172/JCI78421Citation Count: 194
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OPENTitle: Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 PhosphorylationJournal Name: Journal of Visualized ExperimentsPublisher: MyJove CorporationVol:Issue #: 157Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3791/58956Citation Count: 11
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OPENTitle: Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorderJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 5Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-018-0073-1Best OA location URL: https://www.nature.com/articles/s41531-018-0073-1.pdfCitation Count: 30
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OPENTitle: Improving Prediction of Falls and Cognitive Impairment in Parkinson Disease: Protocol for a Decentralized Observational StudyJournal Name: JMIR Research ProtocolsPublisher: JMIR Publications Inc.Vol: 14Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.2196/71955Best OA location URL: https://doi.org/10.2196/71955Citation Count: 0
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OPENTitle: Impact of motor fluctuations on real-life gait in Parkinson’s patientsJournal Name: Gait & PosturePublisher: Elsevier BVVol: 62Issue #:Start Page: 388End Page: 394Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.gaitpost.2018.03.045Best OA location URL: https://publications.aston.ac.uk/id/eprint/33121/1/1_s2.0_S0966636218302832_main.pdfCitation Count: 30
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OPENTitle: Heritability estimates of cortical anatomy: The influence and reliability of different estimation strategiesJournal Name: NeuroImagePublisher: Elsevier BVVol: 178Issue #:Start Page: 78End Page: 91Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuroimage.2018.05.014Best OA location URL: https://eprints.lancs.ac.uk/id/eprint/125120/1/1_s2.0_S1053811918304129_main.pdfCitation Count: 21
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OPENTitle: Feasibility of large-scale deployment of multiple wearable sensors in Parkinson's diseaseJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 12Issue #: 12Start Page: e0189161End Page: e0189161Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0189161Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0189161&type=printableCitation Count: 162