4251 - 4300 of 6171 Results
Title
Year
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OPENTitle: Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2Journal Name: Neurochemical ResearchPublisher: Springer Science and Business Media LLCVol: 44Issue #: 6Start Page: 1446End Page: 1459Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s11064-018-2650-4Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6450775Citation Count: 9
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OPENTitle: Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with diseaseJournal Name: Molecular NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 13Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s13024-018-0282-4Best OA location URL: https://molecularneurodegeneration.biomedcentral.com/track/pdf/10.1186/s13024-018-0282-4Citation Count: 198
- Naftazone in advanced Parkinson's disease: An acute L-DOPA challenge randomized controlled trial2018OPENTitle: Naftazone in advanced Parkinson's disease: An acute L-DOPA challenge randomized controlled trialJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 60Issue #:Start Page: 51End Page: 56Publication Date:Open Access(OA) Status: OPENLicense: other-oaDOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.10.005Best OA location URL: http://www.prd-journal.com/article/S1353802018304310/pdfCitation Count: 16
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OPENTitle: Abstracts from the 50th European Society of Human Genetics Conference: PostersJournal Name: European Journal of Human GeneticsPublisher: Springer Science and Business Media LLCVol: 26Issue #: S1Start Page: 113End Page: 819Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41431-018-0247-7Best OA location URL: https://www.nature.com/articles/s41431-018-0247-7.pdfCitation Count: 3
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OPENTitle: Importance of low diagnostic Accuracy for early Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 33Issue #: 10Start Page: 1551End Page: 1554Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27485Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6544441Citation Count: 104
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OPENTitle: Modulation of intracellular calcium signaling by microRNA-34a-5pJournal Name: Cell Death & DiseasePublisher: Springer Science and Business Media LLCVol: 9Issue #: 10Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41419-018-1050-7Best OA location URL: https://www.nature.com/articles/s41419-018-1050-7.pdfCitation Count: 28
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OPENTitle: Regional vesicular acetylcholine transporter distribution in human brain: A [18F]fluoroethoxybenzovesamicol positron emission tomography studyJournal Name: Journal of Comparative NeurologyPublisher: WileyVol: 526Issue #: 17Start Page: 2884End Page: 2897Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/cne.24541Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cne.24541Citation Count: 58
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OPENTitle: CSF Aβ1–42 level is associated with cognitive decline in early Parkinson’s disease with rapid eye movement sleep behavior disorderJournal Name: Translational NeurodegenerationPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40035-018-0129-5Best OA location URL: https://translationalneurodegeneration.biomedcentral.com/track/pdf/10.1186/s40035-018-0129-5Citation Count: 11
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OPENTitle: USP 14 inhibition corrects an in vivo model of impaired mitophagyJournal Name: EMBO Molecular MedicinePublisher: Springer Science and Business Media LLCVol: 10Issue #: 11Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.15252/emmm.201809014Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/emmm.201809014Citation Count: 90
- Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat2018OPENTitle: Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the ratJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-018-0066-0Best OA location URL: https://www.nature.com/articles/s41531-018-0066-0.pdfCitation Count: 56
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OPENTitle: Lewy body pathology in Alzheimer's disease: A clinicopathological prospective studyJournal Name: Acta Neurologica ScandinavicaPublisher: WileyVol: 139Issue #: 1Start Page: 76End Page: 81Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/ane.13028Citation Count: 42
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OPENTitle: Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's DiseaseJournal Name: PROTEOMICSPublisher: WileyVol: 18Issue #: 20Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/pmic.201800108Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6283072Citation Count: 63
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OPENTitle: Unraveling connectivity changes due to dopaminergic therapy in chronically treated Parkinson’s disease patientsJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 8Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-018-31988-0Best OA location URL: https://www.nature.com/articles/s41598-018-31988-0.pdfCitation Count: 21
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OPENTitle: Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative DisordersJournal Name: JAMAPublisher: American Medical Association (AMA)Vol: 320Issue #: 11Start Page: 1151End Page: 1151Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1001/jama.2018.12917Best OA location URL: https://jamanetwork.com/journals/jama/articlepdf/2702872/jama_ossenkoppele_2018_pc_180007.pdfCitation Count: 373
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OPENTitle: β2‐adrenoreceptor medications and risk of Parkinson diseaseJournal Name: Annals of NeurologyPublisher: WileyVol: 84Issue #: 5Start Page: 683End Page: 693Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/ana.25341Citation Count: 72
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OPENTitle: Common and rare GCH1 variants are associated with Parkinson's diseaseJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 73Issue #:Start Page: 231.e1End Page: 231.e6Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2018.09.008Citation Count: 29
- Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK22018OPENTitle: Insights into the Influence of Specific Splicing Events on the Structural Organization of LRRK2Journal Name: International Journal of Molecular SciencesPublisher: MDPI AGVol: 19Issue #: 9Start Page: 2784End Page: 2784Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3390/ijms19092784Best OA location URL: https://www.mdpi.com/1422-0067/19/9/2784/pdf?version=1537093660Citation Count: 2
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OPENTitle: Modeling and prediction of clinical symptom trajectories in Alzheimer’s disease using longitudinal dataJournal Name: PLOS Computational BiologyPublisher: Public Library of Science (PLoS)Vol: 14Issue #: 9Start Page: e1006376End Page: e1006376Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pcbi.1006376Best OA location URL: https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006376&type=printableCitation Count: 134
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OPENTitle: Autonomic dysfunction and white matter microstructural changes in drug-naïve patients with Parkinson’s diseaseJournal Name: PeerJPublisher: PeerJVol: 6Issue #:Start Page: e5539End Page: e5539Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.7717/peerj.5539Best OA location URL: https://peerj.com/articles/5539.pdfCitation Count: 18
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OPENTitle: Multi-objective particle swarm optimization for postoperative deep brain stimulation targeting of subthalamic nucleus pathwaysJournal Name: Journal of Neural EngineeringPublisher: IOP PublishingVol: 15Issue #: 6Start Page: 066020End Page: 066020Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1088/1741-2552/aae12fBest OA location URL: https://europepmc.org/articles/pmc6424118?pdf=renderCitation Count: 35
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OPENTitle: Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric diseaseJournal Name: Nature NeurosciencePublisher: Springer Science and Business Media LLCVol: 21Issue #: 10Start Page: 1482End Page: 1492Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41593-018-0223-0Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6334654Citation Count: 95
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OPENTitle: Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tauJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 44Issue #: 1Start Page: 222End Page: 223Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41386-018-0204-8Best OA location URL: https://www.nature.com/articles/s41386-018-0204-8.pdfCitation Count: 1
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OPENTitle: Antidepressant potential of metabotropic glutamate receptor mGlu2 and mGlu3 negative allosteric modulatorsJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 44Issue #: 1Start Page: 214End Page: 236Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41386-018-0192-8Best OA location URL: https://www.nature.com/articles/s41386-018-0192-8.pdfCitation Count: 17
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OPENTitle: Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson’s diseaseJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 6Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-018-0596-zBest OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0596-zCitation Count: 70
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OPENTitle: Early detection of Parkinson’s disease through patient questionnaire and predictive modellingJournal Name: International Journal of Medical InformaticsPublisher: Elsevier BVVol: 119Issue #:Start Page: 75End Page: 87Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.ijmedinf.2018.09.008Best OA location URL: https://arxiv.org/pdf/1810.01855Citation Count: 75
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OPENTitle: Impaired hepatic amyloid-beta degradation in Alzheimer’s diseaseJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 13Issue #: 9Start Page: e0203659End Page: e0203659Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0203659Best OA location URL: https://doi.org/10.1371/journal.pone.0203659Citation Count: 66
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OPENTitle: Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagyJournal Name: PLOS GeneticsPublisher: Public Library of Science (PLoS)Vol: 14Issue #: 9Start Page: e1007561End Page: e1007561Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pgen.1007561Best OA location URL: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1007561&type=printableCitation Count: 39
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OPENTitle: Benefits and risks of unilateral and bilateral ventral intermediate nucleus deep brain stimulation for axial essential tremor symptomsJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 60Issue #:Start Page: 126End Page: 132Publication Date:Open Access(OA) Status: OPENLicense: other-oaDOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.09.004Best OA location URL: https://doi.org/10.1016/j.parkreldis.2018.09.004Citation Count: 43
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OPENTitle: Neuromodulation targets pathological not physiological beta bursts during gait in Parkinson's diseaseJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 120Issue #:Start Page: 107End Page: 117Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2018.09.004Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6422345Citation Count: 125
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OPENTitle: Impact of dyskinesia on activities of daily living in Parkinson's disease: Results from pooled phase 3 ADS-5102 clinical trialsJournal Name: Parkinsonism & Related DisordersPublisher: Elsevier BVVol: 60Issue #:Start Page: 118End Page: 125Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.parkreldis.2018.09.005Best OA location URL: https://doi.org/10.1016/j.parkreldis.2018.09.005Citation Count: 29
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OPENTitle: Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin miceJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 120Issue #:Start Page: 76End Page: 87Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.nbd.2018.09.003Best OA location URL: https://doi.org/10.1016/j.nbd.2018.09.003Citation Count: 18
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OPENTitle: Validation of diffusion tensor imaging measures of nigrostriatal neurons in macaquesJournal Name: PLOS ONEPublisher: Public Library of Science (PLoS)Vol: 13Issue #: 9Start Page: e0202201End Page: e0202201Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0202201Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0202201&type=printableCitation Count: 16
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OPENTitle: Destabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the BrainJournal Name: Molecular Therapy - Methods & Clinical DevelopmentPublisher: Elsevier BVVol: 11Issue #:Start Page: 29End Page: 39Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.omtm.2018.08.008Best OA location URL: http://www.cell.com/article/S2329050118300895/pdfCitation Count: 17
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OPENTitle: L-DOPA functionalized, multi-branched gold nanoparticles as brain-targeted nano-vehiclesJournal Name: Nanomedicine: Nanotechnology, Biology and MedicinePublisher: Elsevier BVVol: 15Issue #: 1Start Page: 1End Page: 11Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nano.2018.08.011Best OA location URL: http://hdl.handle.net/10044/1/63483Citation Count: 87
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OPENTitle: Nucleus Basalis of Meynert Stimulation for Dementia: Theoretical and Technical ConsiderationsJournal Name: Frontiers in NeurosciencePublisher: Frontiers Media SAVol: 12Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fnins.2018.00614Best OA location URL: https://doi.org/10.3389/fnins.2018.00614Citation Count: 33
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OPENTitle: Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imagingJournal Name: NeuroImagePublisher: Elsevier BVVol: 184Issue #:Start Page: 293End Page: 316Publication Date:Open Access(OA) Status: OPENLicense: other-oaDOI - Digital Object Identifier: 10.1016/j.neuroimage.2018.08.068Best OA location URL: https://www.sciencedirect.com/science/article/am/pii/S1053811918307663?via%3DihubCitation Count: 659
- Modifiable vascular risk factors, white matter disease and cognition in early Parkinson's disease2018OPENTitle: Modifiable vascular risk factors, white matter disease and cognition in early Parkinson's diseaseJournal Name: European Journal of NeurologyPublisher: WileyVol: 26Issue #: 2Start Page: 246End Page: 246Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/ene.13797Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/6329649Citation Count: 50
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OPENTitle: Algorithmic Complexity of EEG for Prognosis of Neurodegeneration in Idiopathic Rapid Eye Movement Behavior Disorder (RBD)Journal Name: Annals of Biomedical EngineeringPublisher: Springer Science and Business Media LLCVol: 47Issue #: 1Start Page: 282End Page: 296Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s10439-018-02112-0Best OA location URL: https://zenodo.org/record/3507853Citation Count: 27
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OPENTitle: Antibody biomarker for de novo Parkinson disease: attempted validationJournal Name: npj Parkinson's DiseasePublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41531-018-0064-2Best OA location URL: https://www.nature.com/articles/s41531-018-0064-2.pdfCitation Count: 11
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OPENTitle: Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutationsJournal Name: AutophagyPublisher: Informa UK LimitedVol: 15Issue #: 1Start Page: 113End Page: 130Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1080/15548627.2018.1509818Best OA location URL: https://www.tandfonline.com/doi/pdf/10.1080/15548627.2018.1509818?needAccess=trueCitation Count: 193
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OPENTitle: Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s diseaseJournal Name: Journal of NeuroinflammationPublisher: Springer Science and Business Media LLCVol: 15Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12974-018-1286-2Best OA location URL: http://link.springer.com/content/pdf/10.1186/s12974-018-1286-2.pdfCitation Count: 81
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OPENTitle: TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s diseaseJournal Name: Journal of Experimental MedicinePublisher: Rockefeller University PressVol: 215Issue #: 9Start Page: 2247End Page: 2264Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-saDOI - Digital Object Identifier: 10.1084/jem.20180484Best OA location URL: https://rupress.org/jem/article-pdf/215/9/2247/1171465/jem_20180484.pdfCitation Count: 65
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OPENTitle: Proteomic and functional data sets on synaptic mitochondria from rats with genetic ablation of ParkinJournal Name: Data in BriefPublisher: Elsevier BVVol: 20Issue #:Start Page: 568End Page: 572Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.dib.2018.08.053Best OA location URL: https://doi.org/10.1016/j.dib.2018.08.053Citation Count: 2
- Smaller subcortical volume in Parkinson patients with rapid eye movement sleep behavior disorder2018OPENTitle: Smaller subcortical volume in Parkinson patients with rapid eye movement sleep behavior disorderJournal Name: Brain Imaging and BehaviorPublisher: Springer Science and Business Media LLCVol: 13Issue #: 5Start Page: 1352End Page: 1360Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s11682-018-9939-4Best OA location URL: https://link.springer.com/content/pdf/10.1007/s11682-018-9939-4.pdfCitation Count: 30
- Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins2018OPENTitle: Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteinsJournal Name: EMBO reportsPublisher: Springer Science and Business Media LLCVol: 19Issue #: 10Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.15252/embr.201745680Best OA location URL: https://onlinelibrary.wiley.com/doi/pdf/10.15252/embr.201745680Citation Count: 51
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OPENTitle: Subthalamic nucleus deep brain stimulation reduces freezing of gait subtypes and patterns in Parkinson's diseaseJournal Name: Brain StimulationPublisher: Elsevier BVVol: 11Issue #: 6Start Page: 1404End Page: 1406Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.brs.2018.08.016Best OA location URL: http://www.brainstimjrnl.com/article/S1935861X18302997/pdfCitation Count: 9
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OPENTitle: Increased substantia nigra echogenicity in LRRK2 family members without mutationsJournal Name: Movement DisordersPublisher: WileyVol: 33Issue #: 9Start Page: 1504End Page: 1505Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.27443Best OA location URL: https://europepmc.org/articles/pmc6346431?pdf=renderCitation Count: 2
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OPENTitle: Antibody‐based methods for the measurement of α‐synuclein concentration in human cerebrospinal fluid – method comparison and round robin studyJournal Name: Journal of NeurochemistryPublisher: WileyVol: 149Issue #: 1Start Page: 126End Page: 138Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1111/jnc.14569Best OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.14569Citation Count: 47
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OPENTitle: Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer’s and Parkinson’s disease models of neurodegenerationJournal Name: Human Molecular GeneticsPublisher: Oxford University Press (OUP)Vol:Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/hmg/ddy308Citation Count: 30
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OPENTitle: Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsyJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 136Issue #: 5Start Page: 709End Page: 727Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-018-1900-5Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00401-018-1900-5.pdfCitation Count: 59