2061 - 2070 of 9165 Results
Title
Year
- Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal Model2011OPENTitle: Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4) with Oral Efficacy in an Antiparkinsonian Animal ModelJournal Name: Journal of Medicinal ChemistryPublisher: American Chemical Society (ACS)Vol: 54Issue #: 21Start Page: 7639End Page: 7647Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/jm200956qCitation Count: 61
- Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)2009OPENTitle: Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)Journal Name: Journal of Medicinal ChemistryPublisher: American Chemical Society (ACS)Vol: 52Issue #: 14Start Page: 4115End Page: 4118Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/jm9005065Citation Count: 81
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OPENTitle: 7T MRI subthalamic nucleus atlas for use with 3T MRIJournal Name: Journal of Medical ImagingPublisher: SPIE-Intl Soc Optical EngVol: 5Issue #: 01Start Page: 1End Page: 1Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1117/1.jmi.5.1.015002Best OA location URL: https://www.spiedigitallibrary.org/journals/journal-of-medical-imaging/volume-5/issue-1/015002/7T-MRI-subthalamic-nucleus-atlas-for-use-with-3T-MRI/10.1117/1.JMI.5.1.015002.pdfCitation Count: 18
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OPENTitle: A Role for Neuronal Alpha-Synuclein in Gastrointestinal ImmunityJournal Name: Journal of Innate ImmunityPublisher: S. Karger AGVol: 9Issue #: 5Start Page: 456End Page: 463Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1159/000477990Best OA location URL: https://www.karger.com/Article/Pdf/477990Citation Count: 296
- Discovery, Synthesis, and Structure−Activity Relationship Development of a Series of N-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in Rats2011OPENTitle: Discovery, Synthesis, and Structure−Activity Relationship Development of a Series of N-(4-Acetamido)phenylpicolinamides as Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 (mGlu4) with CNS Exposure in RatsJournal Name: Journal of Medicinal ChemistryPublisher: American Chemical Society (ACS)Vol: 54Issue #: 4Start Page: 1106End Page: 1110Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/jm101271sCitation Count: 48
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OPENTitle: Structure–Activity Relationship of N,N′-Disubstituted Pyrimidinetriones as CaV1.3 Calcium Channel-Selective Antagonists for Parkinson’s DiseaseJournal Name: Journal of Medicinal ChemistryPublisher: American Chemical Society (ACS)Vol: 56Issue #: 11Start Page: 4786End Page: 4797Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1021/jm4005048Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4595045Citation Count: 30
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OPENTitle: Isolation of a Human Single Chain Antibody Fragment Against Oligomeric α-Synuclein that Inhibits Aggregation and Prevents α-Synuclein-induced ToxicityJournal Name: Journal of Molecular BiologyPublisher: Elsevier BVVol: 368Issue #: 4Start Page: 1132End Page: 1144Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.jmb.2007.02.089Best OA location URL: http://doi.org/10.1016/j.jmb.2007.02.089Citation Count: 155
- Sustained efficacy and safety of repeated incobotulinumtoxinA (Xeomin®) injections in blepharospasm2013OPENTitle: Sustained efficacy and safety of repeated incobotulinumtoxinA (Xeomin®) injections in blepharospasmJournal Name: Journal of Neural TransmissionPublisher: Springer Science and Business Media LLCVol: 120Issue #: 9Start Page: 1345End Page: 1353Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00702-013-0998-9Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00702-013-0998-9.pdfCitation Count: 66
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OPENTitle: LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell modelsJournal Name: Journal of Molecular MedicinePublisher: Springer Science and Business Media LLCVol: 91Issue #: 4Start Page: 513End Page: 522Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00109-012-0984-yBest OA location URL: https://link.springer.com/content/pdf/10.1007/s00109-012-0984-y.pdfCitation Count: 80
- Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities2011RESTRICTEDTitle: Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding ActivitiesJournal Name: Journal of Molecular BiologyPublisher: Elsevier BVVol: 412Issue #: 1Start Page: 94End Page: 110Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.jmb.2011.07.033Citation Count: 127