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  • Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: Cross-talk between E3s in the endoplasmic reticulum
    2009
    Summary Details
    OPEN
    Title: Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: Cross-talk between E3s in the endoplasmic reticulum
    Author(s): Ayelet Shmueli, Yien Che Tsai, Mei Yang, M Braun, Allan M. Weissman
    Journal Name: Biochemical and Biophysical Research Communications
    Publisher: Elsevier BV
    Vol: 390
    Issue #: 3
    Start Page: 758
    End Page: 762
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.bbrc.2009.10.045
    Citation Count: 54
  • 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
    2010
    Summary Details
    OPEN
    Title: 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
    Author(s): R. Jeremy Nichols, Nicolas Dzamko, Nicholas A. Morrice, David G. Campbell, Mária Deák, Alban Ordureau, Thomas Macartney, Youren Tong, Jie Shen, Alan R. Prescott, Dario R. Alessi
    Journal Name: Biochemical Journal
    Publisher: Portland Press Ltd.
    Vol: 430
    Issue #: 3
    Start Page: 393
    End Page: 404
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1042/bj20100483
    Best OA location URL: https://portlandpress.com/biochemj/article-pdf/430/3/393/878058/bj4300393.pdf
    Citation Count: 385
  • Treatment With Cholinesterase Inhibitors and Memantine of Patients in the Alzheimer's Disease Neuroimaging Initiative
    2011
    Summary Details
    OPEN
    Title: Treatment With Cholinesterase Inhibitors and Memantine of Patients in the Alzheimer's Disease Neuroimaging Initiative
    Author(s): Lon S. Schneider, Philip S. Insel, Michael W. Weiner
    Journal Name: Archives of Neurology
    Publisher: American Medical Association (AMA)
    Vol: 68
    Issue #: 1
    Start Page: 58
    End Page: 58
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1001/archneurol.2010.343
    Citation Count: 151
  • Heterogeneity of Cholinergic Denervation in Parkinson's Disease without Dementia
    2012
    Summary Details
    OPEN
    Title: Heterogeneity of Cholinergic Denervation in Parkinson's Disease without Dementia
    Author(s): Nicolaas I. Bohnen, Martijn L.T.M. Müller, Vikas Kotagal, Robert A. Koeppe, Michael R. Kilbourn, Sid Gilman, Roger L. Albin, Kirk A. Frey
    Journal Name: Journal of Cerebral Blood Flow & Metabolism
    Publisher: SAGE Publications
    Vol: 32
    Issue #: 8
    Start Page: 1609
    End Page: 1617
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1038/jcbfm.2012.60
    Best OA location URL: https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2012.60
    Citation Count: 174
  • Metabolic network expression in parkinsonism: Clinical and dopaminergic correlations
    2016
    Summary Details
    OPEN
    Title: Metabolic network expression in parkinsonism: Clinical and dopaminergic correlations
    Author(s): Ji Hyun Ko, Chong Sik Lee, David Eidelberg
    Journal Name: Journal of Cerebral Blood Flow & Metabolism
    Publisher: SAGE Publications
    Vol: 37
    Issue #: 2
    Start Page: 683
    End Page: 693
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1177/0271678x16637880
    Best OA location URL: https://journals.sagepub.com/doi/pdf/10.1177/0271678X16637880
    Citation Count: 58
  • Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
    2009
    Summary Details
    OPEN
    Title: Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
    Author(s): Hui Xiong, Danling Wang, Linan Chen, Yeun Su Choo, Hong Ma, Chengyuan Tang, Kun Xia, Wei Jiang, Ze’ev A. Ronai, Xiaoxi Zhuang, Zhuohua Zhang
    Journal Name: Journal of Clinical Investigation
    Publisher: American Society for Clinical Investigation
    Vol: 119
    Issue #: 3
    Start Page: 650
    End Page: 660
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1172/jci37617
    Best OA location URL: http://doi.org/10.1172/JCI37617
    Citation Count: 376
  • α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
    2011
    Summary Details
    OPEN
    Title: α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
    Author(s): Christian Hansen, Élodie Angot, Ann‐Louise Bergström, Jennifer A. Steiner, Laura Pieri, Gesine Paul, Tiago F. Outeiro, Ronald Melki, Pekka Kallunki, Karina Fog, Jiayi Li, Patrik Brundin
    Journal Name: Journal of Clinical Investigation
    Publisher: American Society for Clinical Investigation
    Vol: 121
    Issue #: 2
    Start Page: 715
    End Page: 725
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1172/jci43366
    Best OA location URL: https://resolver.sub.uni-goettingen.de/purl?gs-1/7841
    Citation Count: 789
  • Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients
    2011
    Summary Details
    OPEN
    Title: Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients
    Author(s): Hua She, Qian Yang, Kennie R. Shepherd, Yoland Smith, Gary W. Miller, Claudia Testa, Zixu Mao
    Journal Name: Journal of Clinical Investigation
    Publisher: American Society for Clinical Investigation
    Vol: 121
    Issue #: 3
    Start Page: 930
    End Page: 940
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1172/jci43871
    Citation Count: 152
  • Clinical signs in functional (psychogenic) gait disorders: a brief survey
    2016
    Summary Details
    OPEN
    Title: Clinical signs in functional (psychogenic) gait disorders: a brief survey
    Author(s): Leonard L. Sokol, Alberto J. Espay
    Journal Name: Journal of Clinical Movement Disorders
    Publisher: Springer Science and Business Media LLC
    Vol: 3
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1186/s40734-016-0031-1
    Best OA location URL: https://clinicalmovementdisorders.biomedcentral.com/counter/pdf/10.1186/s40734-016-0031-1
    Citation Count: 23
  • Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators
    2008
    Summary Details
    OPEN
    Title: Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators
    Author(s): Colleen M. Niswender, Evan P. Lebois, Qingwei Luo, Kwang‐Ho Kim, Hubert Muchalski, Huiyong Yin, P. Jeffrey Conn, Craig W. Lindsley
    Journal Name: Bioorganic & Medicinal Chemistry Letters
    Publisher: Elsevier BV
    Vol: 18
    Issue #: 20
    Start Page: 5626
    End Page: 5630
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.bmcl.2008.08.087
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3182458
    Citation Count: 58
  • Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    2010
    Summary Details
    OPEN
    Title: Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    Author(s): Heather L. Melrose, Justus C. Dächsel, Bahareh Behrouz, S. Lincoln, Mei Yue, Kelly M. Hinkle, Caroline Kent, Elena Korvatska, Julie P. Taylor, L.M. Witten, Yian Qi Liang, Joel E. Beevers, Mona Boules, Brittany N. Dugger, Vanida A. Serna, A. Gaukhman, Xin Yu, Monica Castanedes‐Casey, Adam Braithwaite, Sina Ogholikhan, Nanlong Yu, D.I. Bass, G. Tyndall, Daniela Berg, Dennis W. Dickson, Christopher Janus, Matthew J. Farrer
    Journal Name: Neurobiology of Disease
    Publisher: Elsevier BV
    Vol: 40
    Issue #: 3
    Start Page: 503
    End Page: 517
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.nbd.2010.07.010
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/2955774
    Citation Count: 266
  • LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease
    2010
    Summary Details
    OPEN
    Title: LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease
    Author(s): Chen Yao, Rabih El Khoury, Wen Wang, Tara A. Byrd, Elizabeth A. Pehek, Colin Thacker, Xiongwei Zhu, Mark A. Smith, Amy L. Wilson‐Delfosse, Shu G. Chen
    Journal Name: Neurobiology of Disease
    Publisher: Elsevier BV
    Vol: 40
    Issue #: 1
    Start Page: 73
    End Page: 81
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.nbd.2010.04.002
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/2926296
    Citation Count: 143
  • Sequencing of the GBA coactivator, Saposin C, in Parkinson disease
    2018
    Summary Details
    OPEN
    Title: Sequencing of the GBA coactivator, Saposin C, in Parkinson disease
    Author(s): Bouchra Ouled Amar Bencheikh, Etienne Léveillé, Jennifer A. Ruskey, Dan Spiegelman, Christopher Liong, Edward A. Fon, Guy A. Rouleau, Yves Dauvilliers, Nicolas Dupré, Roy N. Alcalay, Ziv Gan‐Or
    Journal Name: Neurobiology of Aging
    Publisher: Elsevier BV
    Vol: 72
    Issue #:
    Start Page: 187.e1
    End Page: 187.e3
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2018.06.034
    Citation Count: 22
  • Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
    2011
    Summary Details
    OPEN
    Title: Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
    Author(s): Michael J. Devine, Mina Ryten, Petr Vodička, Alison J. Thomson, Tom Burdon, Henry Houlden, Fatima Cavaleri, Masumi Nagano, Nicola J. Drummond, Jan‐Willem Taanman, Anthony H.V. Schapira, Katrina Gwinn, John Hardy, Patrick A. Lewis, Tilo Kunath
    Journal Name: Nature Communications
    Publisher: Springer Science and Business Media LLC
    Vol: 2
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-sa
    DOI - Digital Object Identifier: 10.1038/ncomms1453
    Best OA location URL: https://www.nature.com/articles/ncomms1453.pdf
    Citation Count: 445
  • Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
    2015
    Summary Details
    OPEN
    Title: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
    Author(s): Ulf Dettmer, Andrew J. Newman, Frank Soldner, Eric S. Luth, Nora C. Kim, Victoria E. von Saucken, John Sanderson, Rudolf Jaenisch, Tim Bartels, Dennis J. Selkoe
    Journal Name: Nature Communications
    Publisher: Springer Science and Business Media LLC
    Vol: 6
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/ncomms8314
    Best OA location URL: https://www.nature.com/articles/ncomms8314.pdf
    Citation Count: 280
  • Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
    2016
    Summary Details
    OPEN
    Title: Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
    Author(s): Qingde Zhou, Allen Yen, Grzegorz Rymarczyk, Hirohide Asai, Chelsea Trengrove, Nadine Aziz, Michael T. Kirber, Gustavo Mostoslavsky, Tsuneya Ikezu, Benjamin Wolozin, Victoria M. Bolotina, Qingde Zhou, Allen Yen, Grzegorz Rymarczyk, Hirohide Asai, Chelsea Trengrove, Nadine Aziz, Michael T. Kirber, Gustavo Mostoslavsky, Tsuneya Ikezu, Benjamin Wolozin, Victoria M. Bolotina
    Journal Name: Nature Communications
    Publisher: Springer Science and Business Media LLC
    Vol: 7
    Issue #: 1
    Start Page: 10332
    End Page: 10332
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/ncomms10332
    Best OA location URL: https://www.nature.com/articles/ncomms10332.pdf
    Citation Count: 94
  • O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease
    2015
    Summary Details
    OPEN
    Title: O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease
    Author(s): Nicholas P. Marotta, Yu Lin, Yuka E. Lewis, Mark R. Ambroso, Balyn W. Zaro, Maxwell T. Roth, Don B. Arnold, Ralf Langen, Matthew R. Pratt
    Journal Name: Nature Chemistry
    Publisher: Springer Science and Business Media LLC
    Vol: 7
    Issue #: 11
    Start Page: 913
    End Page: 920
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1038/nchem.2361
    Best OA location URL: http://doi.org/10.1038/nchem.2361
    Citation Count: 253
  • Tardive Dyskinesia: Therapeutic Options for an Increasingly Common Disorder
    2013
    Summary Details
    OPEN
    Title: Tardive Dyskinesia: Therapeutic Options for an Increasingly Common Disorder
    Author(s): Leslie Cloud, Deepti Zutshi, Stewart A. Factor
    Journal Name: Neurotherapeutics
    Publisher: Elsevier BV
    Vol: 11
    Issue #: 1
    Start Page: 166
    End Page: 176
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1007/s13311-013-0222-5
    Best OA location URL: https://link.springer.com/content/pdf/10.1007/s13311-013-0222-5.pdf
    Citation Count: 106
  • A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy
    2014
    Summary Details
    OPEN
    Title: A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy
    Author(s): Franziska Richter, Sheila M. Fleming, Melanie B. Watson, Vincent Lemesre, Lee Pellegrino, Brian Ranes, Chunni Zhu, Farzad Mortazavi, Caitlin Mulligan, Pedrom C. Sioshansi, Sindalana Hean, Krystal De La Rosa, Richie Khanna, John J. Flanagan, David J. Lockhart, Brandon A. Wustman, Sean W. Clark, Marie‐Françoise Chesselet
    Journal Name: Neurotherapeutics
    Publisher: Elsevier BV
    Vol: 11
    Issue #: 4
    Start Page: 840
    End Page: 856
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1007/s13311-014-0294-x
    Best OA location URL: https://link.springer.com/content/pdf/10.1007/s13311-014-0294-x.pdf
    Citation Count: 98
  • Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
    2010
    Summary Details
    OPEN
    Title: Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
    Author(s): Thomas G. Beach, Charles H. Adler, Lucia I. Sue, Linda Vedders, Lih-Fen Lue, Charles L. White, Haru Akiyama, John N. Caviness, Holly A. Shill, Marwan N. Sabbagh, Douglas G. Walker
    Journal Name: Acta Neuropathologica
    Publisher: Springer Science and Business Media LLC
    Vol: 119
    Issue #: 6
    Start Page: 689
    End Page: 702
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1007/s00401-010-0664-3
    Citation Count: 795
  • Heterogeneous neuropathological findings in Parkinson’s disease with mild cognitive impairment
    2010
    Summary Details
    OPEN
    Title: Heterogeneous neuropathological findings in Parkinson’s disease with mild cognitive impairment
    Author(s): Charles H. Adler, John N. Caviness, Marwan N. Sabbagh, Holly A. Shill, Donald J. Connor, Lucia I. Sue, Virgilio Gerald H. Evidente, Erika Driver‐Dunckley, Thomas G. Beach
    Journal Name: Acta Neuropathologica
    Publisher: Springer Science and Business Media LLC
    Vol: 120
    Issue #: 6
    Start Page: 827
    End Page: 828
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1007/s00401-010-0744-4
    Citation Count: 84
  • Latent growth-curve analysis reveals that worsening Parkinson’s disease quality of life is driven by depression.
    2014
    Summary Details
    OPEN
    Title: Latent growth-curve analysis reveals that worsening Parkinson’s disease quality of life is driven by depression.
    Author(s): Jacob D. Jones, Michael Marsiske, Michael S. Okun, Dawn Bowers
    Journal Name: Neuropsychology
    Publisher: American Psychological Association (APA)
    Vol: 29
    Issue #: 4
    Start Page: 603
    End Page: 609
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1037/neu0000158
    Best OA location URL: http://doi.org/10.1037/neu0000158
    Citation Count: 20
  • Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease
    2013
    Summary Details
    OPEN
    Title: Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease
    Author(s): Kurt M. Lucin, Caitlin E. O’Brien, Gregor Bieri, Eva Czirr, Kira I. Mosher, Rachelle Abbey, Diego Mastroeni, Joseph Rogers, Brian Spencer, Eliezer Masliah, Tony Wyss‐Coray
    Journal Name: Neuron
    Publisher: Elsevier BV
    Vol: 79
    Issue #: 5
    Start Page: 873
    End Page: 886
    Publication Date:
    Open Access(OA) Status: OPEN
    License: publisher-specific-oa
    DOI - Digital Object Identifier: 10.1016/j.neuron.2013.06.046
    Best OA location URL: http://www.cell.com/article/S089662731300562X/pdf
    Citation Count: 345
  • The Linked Clinical Trials initiative (LCT) for Parkinson's disease
    2018
    Summary Details
    RESTRICTED
    Title: The Linked Clinical Trials initiative (LCT) for Parkinson's disease
    Author(s): Patrik Brundin, Richard Wyse
    Journal Name: European Journal of Neuroscience
    Publisher: Wiley
    Vol: 49
    Issue #: 3
    Start Page: 307
    End Page: 315
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1111/ejn.14175
    Citation Count: 19
  • Recent Advances in Cholinergic Imaging and Cognitive Decline—Revisiting the Cholinergic Hypothesis of Dementia
    2018
    Summary Details
    OPEN
    Title: Recent Advances in Cholinergic Imaging and Cognitive Decline—Revisiting the Cholinergic Hypothesis of Dementia
    Author(s): Nicolaas I. Bohnen, Michel J. Grothe, Nicola J. Ray, Martijn L.T.M. Müller, Stefan Teipel
    Journal Name: Current Geriatrics Reports
    Publisher: Springer Science and Business Media LLC
    Vol: 7
    Issue #: 1
    Start Page: 1
    End Page: 11
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1007/s13670-018-0234-4
    Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/5831510
    Citation Count: 108
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