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5701 - 5750 of 8571 Results
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  • Summary Details
    OPEN
    Title: Proteomic identification of proteins in the human brain: Towards a more comprehensive understanding of neurodegenerative disease
    Journal Name: PROTEOMICS – Clinical Applications
    Publisher: Wiley
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1002/prca.200800043
    Citation Count: 27
  • Summary Details
    OPEN
    Title: Derivation of midbrain dopamine neurons from human embryonic stem cells
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0404700101
    Citation Count: 984
  • Summary Details
    OPEN
    Title: Neuroectodermal differentiation from mouse multipotent adult progenitor cells
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1834196100
    Citation Count: 356
  • Summary Details
    OPEN
    Title: Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinson's disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0405313101
    Citation Count: 320
  • Summary Details
    OPEN
    Title: Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0501282102
    Citation Count: 683
  • Summary Details
    OPEN
    Title: Molecular markers of early Parkinson's disease based on gene expression in blood
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0610204104
    Citation Count: 493
  • Summary Details
    OPEN
    Title: Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0606401103
    Citation Count: 164
  • Summary Details
    OPEN
    Title: Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0602116103
    Citation Count: 136
  • Summary Details
    OPEN
    Title: Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0605208103
    Citation Count: 571
  • Summary Details
    OPEN
    Title: Physiology versus pathology in Parkinson's disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0704254104
    Citation Count: 11
  • Summary Details
    OPEN
    Title: Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0704908104
    Citation Count: 416
  • Summary Details
    OPEN
    Title: Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0704091104
    Citation Count: 347
  • Summary Details
    OPEN
    Title: Murine models of acute neuronopathic Gaucher disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0708086104
    Citation Count: 188
  • Summary Details
    OPEN
    Title: Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0705363105
    Citation Count: 249
  • Summary Details
    OPEN
    Title: GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0802437105
    Citation Count: 258
  • Summary Details
    OPEN
    Title: Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0900096106
    Citation Count: 428
  • Summary Details
    OPEN
    Title: R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0906334106
    Citation Count: 287
  • Summary Details
    OPEN
    Title: Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0810996106
    Citation Count: 140
  • Summary Details
    OPEN
    Title: Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0902396106
    Citation Count: 219
  • Summary Details
    OPEN
    Title: Targeting neural precursors in the adult brain rescues injured dopamine neurons
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0905125106
    Citation Count: 95
  • Summary Details
    OPEN
    Title: Unexpected expression of α- and β-globin in mesencephalic dopaminergic neurons and glial cells
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.0813216106
    Citation Count: 256
  • Summary Details
    OPEN
    Title: Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1004676107
    Citation Count: 488
  • Summary Details
    OPEN
    Title: In vivo demonstration that α-synuclein oligomers are toxic
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1100976108
    Citation Count: 1385
  • Summary Details
    OPEN
    Title: Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1012500108
    Citation Count: 88
  • Summary Details
    OPEN
    Title: Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1217296110
    Citation Count: 115
  • Summary Details
    OPEN
    Title: Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1309991110
    Citation Count: 174
  • Summary Details
    OPEN
    Title: Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1318306111
    Citation Count: 350
  • Summary Details
    OPEN
    Title: A soluble α-synuclein construct forms a dynamic tetramer
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1113260108
    Best OA location URL:
    Citation Count: 439
  • Summary Details
    OPEN
    Title: Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1312701111
    Citation Count: 114
  • Summary Details
    OPEN
    Title: Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1203223109
    Citation Count: 95
  • Summary Details
    OPEN
    Title: Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1205102109
    Citation Count: 86
  • Summary Details
    OPEN
    Title: Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1323285111
    Citation Count: 109
  • Summary Details
    OPEN
    Title: Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1321845111
    Citation Count: 198
  • Summary Details
    OPEN
    Title: Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1220399110
    Citation Count: 191
  • Summary Details
    OPEN
    Title: CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1519430112
    Citation Count: 29
  • Summary Details
    OPEN
    Title: α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1417883112
    Citation Count: 139
  • Summary Details
    OPEN
    Title: Abrogation of α-synuclein–mediated dopaminergic neurodegeneration in LRRK2-deficient rats
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1403215111
    Citation Count: 206
  • Summary Details
    OPEN
    Title: Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1522872114
    Citation Count: 113
  • Summary Details
    OPEN
    Title: Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1509742112
    Citation Count: 177
  • Summary Details
    OPEN
    Title: Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1608784113
    Citation Count: 53
  • Summary Details
    OPEN
    Title: Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson’s disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1621218114
    Citation Count: 34
  • Summary Details
    OPEN
    Title: Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson’s disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1713849115
    Citation Count: 185
  • Summary Details
    OPEN
    Title: Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease
    Journal Name: Proceedings of the National Academy of Sciences
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1073/pnas.1718946115
    Citation Count: 106
  • Summary Details
    OPEN
    Title: Quantification of brain cholinergic denervation in dementia with Lewy bodies using PET imaging with [18F]-FEOBV
    Journal Name: Molecular Psychiatry
    Publisher: Springer Science and Business Media LLC
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1038/s41380-018-0130-5
    Citation Count: 62
  • Summary Details
    OPEN
    Title: Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 Vectors
    Journal Name: Molecular Therapy
    Publisher: Elsevier BV
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/mt.2010.114
    Citation Count: 80
  • Summary Details
    OPEN
    Title: Long-term Transgene Expression in the Central Nervous System Using DNA Nanoparticles
    Journal Name: Molecular Therapy
    Publisher: Elsevier BV
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/mt.2009.2
    Citation Count: 77
  • Summary Details
    OPEN
    Title: Interventional MRI-guided Putaminal Delivery of AAV2-GDNF for a Planned Clinical Trial in Parkinson's Disease
    Journal Name: Molecular Therapy
    Publisher: Elsevier BV
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/mt.2011.11
    Citation Count: 135
  • Summary Details
    OPEN
    Title: Striatal Pleiotrophin Overexpression Provides Functional and Morphological Neuroprotection in the 6-Hydroxydopamine Model
    Journal Name: Molecular Therapy
    Publisher: Elsevier BV
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/mt.2011.216
    Citation Count: 30
  • Summary Details
    OPEN
    Title: Functional Neuroprotection and Efficient Regulation of GDNF Using Destabilizing Domains in a Rodent Model of Parkinson’s Disease
    Journal Name: Molecular Therapy
    Publisher: Elsevier BV
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/mt.2013.169
    Citation Count: 55
  • Summary Details
    OPEN
    Title: Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain
    Journal Name: Molecular Therapy
    Publisher: Elsevier BV
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/mt.2009.286
    Citation Count: 125
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