2701 - 2750 of 8808 Results
Title
Year
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OPENTitle: Essential tremor and Parkinson's disease: Lack of a linkJournal Name: Movement DisordersPublisher: WileyVol: 26Issue #: 3Start Page: 372End Page: 377Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.23509Citation Count: 62
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OPENTitle: Noninvasive optical inhibition with a red-shifted microbial rhodopsinJournal Name: Nature NeurosciencePublisher: Springer Science and Business Media LLCVol: 17Issue #: 8Start Page: 1123End Page: 1129Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/nn.3752Best OA location URL: http://doi.org/10.1038/nn.3752Citation Count: 542
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OPENTitle: Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 103Issue #: 49Start Page: 18757End Page: 18762Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0606401103Citation Count: 165
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OPENTitle: Sex-specific genetic predictors of Alzheimer’s disease biomarkersJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 136Issue #: 6Start Page: 857End Page: 872Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-018-1881-4Citation Count: 106
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OPENTitle: Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagyJournal Name: Human Molecular GeneticsPublisher: Oxford University Press (OUP)Vol: 23Issue #: 16Start Page: 4201End Page: 4214Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/hmg/ddu138Best OA location URL: https://academic.oup.com/hmg/article-pdf/23/16/4201/1737006/ddu138.pdfCitation Count: 221
- MitoPark mice mirror the slow progression of key symptoms and L‐DOPA response in Parkinson's disease2009OPENTitle: MitoPark mice mirror the slow progression of key symptoms and L‐DOPA response in Parkinson's diseaseJournal Name: Genes, Brain and BehaviorPublisher: WileyVol: 9Issue #: 2Start Page: 173End Page: 181Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1601-183x.2009.00542.xBest OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1601-183X.2009.00542.xCitation Count: 104
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OPENTitle: Imaging of microglia in patients with neurodegenerative disordersJournal Name: Frontiers in PharmacologyPublisher: Frontiers Media SAVol: 3Issue #:Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.3389/fphar.2012.00096Best OA location URL: https://kclpure.kcl.ac.uk/portal/en/publications/389ab5ad-f662-40b8-981e-c6f04a287c58Citation Count: 112
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OPENTitle: Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's diseaseJournal Name: BrainPublisher: Oxford University Press (OUP)Vol: 135Issue #: 11Start Page: 3355End Page: 3370Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/brain/aws254Best OA location URL: https://resolver.sub.uni-goettingen.de/purl?gs-1/9499Citation Count: 169
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OPENTitle: Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s DiseaseJournal Name: PLoS ONEPublisher: Public Library of Science (PLoS)Vol: 8Issue #: 8Start Page: e70274End Page: e70274Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0070274Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0070274&type=printableCitation Count: 178
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OPENTitle: Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population‐based elderly cohortJournal Name: Alzheimer's & DementiaPublisher: WileyVol: 12Issue #: 12Start Page: 1226End Page: 1234Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.jalz.2016.06.001Best OA location URL: http://doi.org/10.1016/j.jalz.2016.06.001Citation Count: 127
- CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease2012OPENTitle: CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s DiseaseJournal Name: Journal of Neuroimmune PharmacologyPublisher: Springer Science and Business Media LLCVol: 7Issue #: 4Start Page: 927End Page: 938Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s11481-012-9402-zBest OA location URL: https://link.springer.com/content/pdf/10.1007/s11481-012-9402-z.pdfCitation Count: 300
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OPENTitle: Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissueJournal Name: Acta Neuropathologica CommunicationsPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s40478-016-0371-yBest OA location URL: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-016-0371-yCitation Count: 68
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OPENTitle: Differential regulation of Mn-superoxide dismutase in neurons and astroglia by HIV-1 gp120: Implications for HIV-associated dementiaJournal Name: Free Radical Biology and MedicinePublisher: Elsevier BVVol: 42Issue #: 12Start Page: 1866End Page: 1878Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.freeradbiomed.2007.03.022Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/1955471Citation Count: 50
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OPENTitle: Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microgliaJournal Name: Journal of NeuroinflammationPublisher: Springer Science and Business Media LLCVol: 11Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/s12974-014-0164-9Best OA location URL: https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/s12974-014-0164-9Citation Count: 31
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OPENTitle: α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and NeurodegenerationJournal Name: Cell ReportsPublisher: Elsevier BVVol: 7Issue #: 6Start Page: 2054End Page: 2065Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1016/j.celrep.2014.05.033Best OA location URL: https://doi.org/10.1016/j.celrep.2014.05.033Citation Count: 313
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OPENTitle: Short- and Long-Term Effects of LRRK2 on Axon and Dendrite GrowthJournal Name: PLoS ONEPublisher: Public Library of Science (PLoS)Vol: 8Issue #: 4Start Page: e61986End Page: e61986Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1371/journal.pone.0061986Best OA location URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061986&type=printableCitation Count: 48
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OPENTitle: LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson’s diseaseJournal Name: Human Molecular GeneticsPublisher: Oxford University Press (OUP)Vol: 26Issue #: 22Start Page: 4340End Page: 4351Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1093/hmg/ddx320Best OA location URL: https://academic.oup.com/hmg/article-pdf/26/22/4340/24339268/ddx320.pdfCitation Count: 90
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OPENTitle: Peripheral Administration of the Selective Inhibitor of Soluble Tumor Necrosis Factor (TNF) XPro®1595 Attenuates Nigral Cell Loss and Glial Activation in 6-OHDA Hemiparkinsonian RatsJournal Name: Journal of Parkinson's DiseasePublisher: SAGE PublicationsVol: 4Issue #: 3Start Page: 349End Page: 360Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jpd-140410Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4154985Citation Count: 103
- Reduced uptake of [ 18 F]FDOPA PET in asymptomatic welders with occupational manganese exposure2011OPENTitle: Reduced uptake of [ 18 F]FDOPA PET in asymptomatic welders with occupational manganese exposureJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 76Issue #: 15Start Page: 1296End Page: 1301Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e3182152830Best OA location URL: https://n.neurology.org/content/neurology/76/15/1296.full.pdfCitation Count: 83
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OPENTitle: Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple SclerosisJournal Name: Biological PsychiatryPublisher: Elsevier BVVol: 80Issue #: 1Start Page: 62End Page: 72Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1016/j.biopsych.2015.11.022Best OA location URL: https://kclpure.kcl.ac.uk/ws/files/46558917/1_s2.0_S0006322315010252_main.pdfCitation Count: 134
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OPENTitle: VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's diseaseJournal Name: Neurobiology of DiseasePublisher: Elsevier BVVol: 37Issue #: 2Start Page: 330End Page: 338Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.nbd.2009.10.011Citation Count: 74
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OPENTitle: A role for a novel protein, nucleolin, in Parkinson's diseaseJournal Name: Neuroscience LettersPublisher: Elsevier BVVol: 459Issue #: 1Start Page: 11End Page: 15Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neulet.2009.04.060Best OA location URL: http://doi.org/10.1016/j.neulet.2009.04.060Citation Count: 46
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OPENTitle: Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 110Issue #: 2Start Page: 636End Page: 641Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1220399110Best OA location URL: https://www.pnas.org/content/pnas/110/2/636.full.pdfCitation Count: 193
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OPENTitle: In vitro high affinity α‐synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain1Journal Name: Journal of NeurochemistryPublisher: WileyVol: 105Issue #: 4Start Page: 1428End Page: 1437Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/j.1471-4159.2008.05245.xBest OA location URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2008.05245.xCitation Count: 92
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OPENTitle: Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 109Issue #: 39Start Page: 15918End Page: 15923Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1205102109Best OA location URL: https://www.pnas.org/content/pnas/109/39/15918.full.pdfCitation Count: 87
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OPENTitle: A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathologyJournal Name: Nature NeurosciencePublisher: Springer Science and Business Media LLCVol: 22Issue #: 1Start Page: 47End Page: 56Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41593-018-0298-7Citation Count: 217
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OPENTitle: In vivo demonstration that α-synuclein oligomers are toxicJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 108Issue #: 10Start Page: 4194End Page: 4199Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1100976108Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3053976Citation Count: 1395
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OPENTitle: The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactionsJournal Name: Scientific ReportsPublisher: Springer Science and Business Media LLCVol: 7Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1038/s41598-017-05760-9Best OA location URL: https://www.nature.com/articles/s41598-017-05760-9.pdfCitation Count: 64
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OPENTitle: Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodiesJournal Name: mAbsPublisher: Informa UK LimitedVol: 4Issue #: 6Start Page: 686End Page: 693Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.4161/mabs.21696Best OA location URL: https://www.tandfonline.com/doi/pdf/10.4161/mabs.21696?needAccess=trueCitation Count: 68
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OPENTitle: Age-specific penetrance ofLRRK2G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 ConsortiumJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 85Issue #: 1Start Page: 89End Page: 95Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0000000000001708Best OA location URL: https://n.neurology.org/content/neurology/85/1/89.full.pdfCitation Count: 158
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OPENTitle: Pure hereditary spastic paraplegia due to a de novo mutation in the NIPA1 geneJournal Name: European Journal of NeurologyPublisher: WileyVol: 21Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1111/ene.12284Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4138605Citation Count: 8
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OPENTitle: Pre- and post-synaptic cortical cholinergic deficits are proportional to amyloid plaque presence and density at preclinical stages of Alzheimer’s diseaseJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 122Issue #: 1Start Page: 49End Page: 60Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1007/s00401-011-0831-1Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3362487Citation Count: 93
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OPENTitle: The relationship between obsessive‐compulsive symptoms and PARKIN genotype: The CORE‐PD studyJournal Name: Movement DisordersPublisher: WileyVol: 30Issue #: 2Start Page: 278End Page: 283Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.26065Best OA location URL: http://doi.org/10.1002/mds.26065Citation Count: 19
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OPENTitle: Peptidoglycan recognition protein genes and risk of Parkinson's diseaseJournal Name: Movement DisordersPublisher: WileyVol: 29Issue #: 9Start Page: 1171End Page: 1180Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.25895Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4777298Citation Count: 48
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OPENTitle: Results of the citalopram to enhance cognition in Huntington disease trialJournal Name: Movement DisordersPublisher: WileyVol: 29Issue #: 3Start Page: 401End Page: 405Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.25750Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3960314Citation Count: 59
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OPENTitle: The Unified Parkinson�s Disease Rating Scale as a predictor of peak aerobic capacity and ambulatory functionJournal Name: The Journal of Rehabilitation Research and DevelopmentPublisher: Journal of Rehabilitation Research & DevelopmentVol: 49Issue #: 8Start Page: 1269End Page: 1269Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1682/jrrd.2011.06.0103Citation Count: 27
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OPENTitle: Reliability of a new scale for essential tremorJournal Name: Movement DisordersPublisher: WileyVol: 27Issue #: 12Start Page: 1567End Page: 1569Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mds.25162Best OA location URL: http://doi.org/10.1002/mds.25162Citation Count: 211
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OPENTitle: Impaired perception of biological motion in Parkinson’s disease.Journal Name: NeuropsychologyPublisher: American Psychological Association (APA)Vol: 30Issue #: 6Start Page: 720End Page: 730Publication Date:Open Access(OA) Status: OPENLicense: other-oaDOI - Digital Object Identifier: 10.1037/neu0000276Best OA location URL: https://doi.org/10.1037/neu0000276Citation Count: 51
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OPENTitle: Evaluation of the D3 dopamine receptor selective antagonist PG01037 on l-dopa-dependent abnormal involuntary movements in ratsJournal Name: NeuropharmacologyPublisher: Elsevier BVVol: 56Issue #: 6-7Start Page: 944End Page: 955Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neuropharm.2009.01.020Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3820009Citation Count: 46
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OPENTitle: Morphological Alterations in the Thalamus, Striatum, and Pallidum in Autism Spectrum DisorderJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 41Issue #: 11Start Page: 2627End Page: 2637Publication Date:Open Access(OA) Status: OPENLicense: cc-by-nc-ndDOI - Digital Object Identifier: 10.1038/npp.2016.64Best OA location URL: https://www.nature.com/articles/npp201664.pdfCitation Count: 148
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OPENTitle: Prefrontal White Matter Structure Mediates the Influence of GAD1 on Working MemoryJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 41Issue #: 9Start Page: 2224End Page: 2231Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/npp.2016.14Best OA location URL: https://www.nature.com/articles/npp201614.pdfCitation Count: 27
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OPENTitle: mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shellJournal Name: NeuropsychopharmacologyPublisher: Springer Science and Business Media LLCVol: 43Issue #: 10Start Page: 2075End Page: 2082Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1038/s41386-018-0049-1Best OA location URL: https://www.nature.com/articles/s41386-018-0049-1.pdfCitation Count: 30
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OPENTitle: Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppressionJournal Name: Neural DevelopmentPublisher: Springer Science and Business Media LLCVol: 4Issue #: 1Start Page:End Page:Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1186/1749-8104-4-11Best OA location URL: https://neuraldevelopment.biomedcentral.com/counter/pdf/10.1186/1749-8104-4-11Citation Count: 40
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OPENTitle: Presence of Striatal Amyloid Plaques in Parkinson's Disease Dementia Predicts Concomitant Alzheimer's Disease: Usefulness for Amyloid ImagingJournal Name: Journal of Parkinson’s DiseasePublisher: SAGE PublicationsVol: 2Issue #: 1Start Page: 57End Page: 65Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.3233/jpd-2012-11073Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3423968Citation Count: 40
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OPENTitle: Expert Testimony at the Food and Drug Administration: Who Wants the Truth?Journal Name: Narrative Inquiry in BioethicsPublisher: Project MUSEVol: 1Issue #: 2Start Page: 78End Page: 82Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1353/nib.2011.0046Citation Count: 0
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OPENTitle: Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s diseaseJournal Name: Acta NeuropathologicaPublisher: Springer Science and Business Media LLCVol: 129Issue #: 4Start Page: 565End Page: 583Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1007/s00401-015-1395-2Best OA location URL: https://link.springer.com/content/pdf/10.1007/s00401-015-1395-2.pdfCitation Count: 50
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OPENTitle: Models for LRRK2-Linked ParkinsonismJournal Name: Parkinson's DiseasePublisher: WileyVol: 2011Issue #:Start Page: 1End Page: 16Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.4061/2011/942412Best OA location URL: https://downloads.hindawi.com/journals/pd/2011/942412.pdfCitation Count: 35
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OPENTitle: Atypical presentation of late‐onset Tay‐sachs diseaseJournal Name: Muscle & NervePublisher: WileyVol: 49Issue #: 5Start Page: 768End Page: 771Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1002/mus.24146Best OA location URL: http://doi.org/10.1002/mus.24146Citation Count: 37
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OPENTitle: Mitochondrial DNA haplogroups and mutations in children with acquired central demyelinationJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 76Issue #: 9Start Page: 774End Page: 780Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e31820ee1bbBest OA location URL: https://n.neurology.org/content/neurology/76/9/774.full.pdfCitation Count: 17
- Glucocerebrosidase mutations are not a common risk factor for Parkinson disease in North Africa2009RESTRICTEDTitle: Glucocerebrosidase mutations are not a common risk factor for Parkinson disease in North AfricaJournal Name: Neuroscience LettersPublisher: Elsevier BVVol: 477Issue #: 2Start Page: 57End Page: 60Publication Date:Open Access(OA) Status: RESTRICTEDLicense:DOI - Digital Object Identifier: 10.1016/j.neulet.2009.11.066Citation Count: 25