2951 - 3000 of 8620 Results
Title
Year
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OPENTitle: Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseasesJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 38Issue #:Start Page: 214.e7End Page: 214.e10Publication Date:Open Access(OA) Status: OPENLicense: cc-by, cc-byDOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2015.10.028Best OA location URL: https://doi.org/10.1016/j.neurobiolaging.2015.10.028Citation Count: 87
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OPENTitle: Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's diseaseJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 34Issue #: 8Start Page: 2077.e11End Page: 2077.e18Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2013.02.016Best OA location URL: http://doi.org/10.1016/j.neurobiolaging.2013.02.016Citation Count: 140
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OPENTitle: Multiple system atrophy is not caused by C9orf72 hexanucleotide repeat expansionsJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 36Issue #: 2Start Page: 1223.e1End Page: 1223.e2Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2014.08.033Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/4315721Citation Count: 30
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OPENTitle: Mutational analysis of parkin and PINK1 in multiple system atrophyJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 32Issue #: 3Start Page: 548.e5End Page: 548.e7Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2009.11.020Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3934211Citation Count: 21
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OPENTitle: Microglial responses to dopamine in a cell culture model of Parkinson's diseaseJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 30Issue #: 11Start Page: 1805End Page: 1817Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2008.01.001Citation Count: 109
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OPENTitle: MAPT H1 haplotype is a risk factor for essential tremor and multiple system atrophyJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 76Issue #: 7Start Page: 670End Page: 672Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e31820c30c1Best OA location URL: http://n.neurology.org/content/neurology/76/7/670.full.pdfCitation Count: 72
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OPENTitle: Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's diseaseJournal Name: Neurobiology of AgingPublisher: Elsevier BVVol: 36Issue #: 12Start Page: 3121End Page: 3129Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1016/j.neurobiolaging.2015.08.017Best OA location URL: http://doi.org/10.1016/j.neurobiolaging.2015.08.017Citation Count: 54
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OPENTitle: Quantitative EEG as a predictive biomarker for Parkinson disease dementiaJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 77Issue #: 2Start Page: 118End Page: 124Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318224af8dBest OA location URL: https://n.neurology.org/content/neurology/77/2/118.full.pdfCitation Count: 201
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OPENTitle: Olfaction in Parkin heterozygotes and compound heterozygotesJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 76Issue #: 4Start Page: 319End Page: 326Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e31820882aaBest OA location URL: https://n.neurology.org/content/neurology/76/4/319.full.pdfCitation Count: 48
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OPENTitle: Olfactory dysfunction in LRRK2 G2019S mutation carriersJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 77Issue #: 4Start Page: 319End Page: 324Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318227041cBest OA location URL: https://n.neurology.org/content/neurology/77/4/319.full.pdfCitation Count: 62
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OPENTitle: Mitochondrial DNA haplogroups and mutations in children with acquired central demyelinationJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 76Issue #: 9Start Page: 774End Page: 780Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e31820ee1bbBest OA location URL: https://n.neurology.org/content/neurology/76/9/774.full.pdfCitation Count: 17
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OPENTitle: A family with parkinsonism, essential tremor, restless legs syndrome, and depressionJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 76Issue #: 19Start Page: 1623End Page: 1630Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318219fb42Best OA location URL: https://n.neurology.org/content/neurology/76/19/1623.full.pdfCitation Count: 28
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OPENTitle: Quantifying physical decline in juvenile neuronal ceroid lipofuscinosis (Batten disease)Journal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 77Issue #: 20Start Page: 1801End Page: 1807Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318237f649Best OA location URL: https://n.neurology.org/content/neurology/77/20/1801.full.pdfCitation Count: 56
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OPENTitle: Stress and the risk of multiple sclerosisJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 76Issue #: 22Start Page: 1866End Page: 1871Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e31821d74c5Best OA location URL: https://n.neurology.org/content/neurology/76/22/1866.full.pdfCitation Count: 68
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OPENTitle: Quantitative telemedicine ratings in Batten diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 77Issue #: 20Start Page: 1808End Page: 1811Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e3182377e29Citation Count: 27
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OPENTitle: GFAP mutations, age at onset, and clinical subtypes in Alexander diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 77Issue #: 13Start Page: 1287End Page: 1294Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e3182309f72Best OA location URL: https://n.neurology.org/content/neurology/77/13/1287.full.pdfCitation Count: 230
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OPENTitle: Habitual intake of dietary flavonoids and risk of Parkinson diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 78Issue #: 15Start Page: 1138End Page: 1145Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e31824f7fc4Best OA location URL: https://n.neurology.org/content/neurology/78/15/1138.full.pdfCitation Count: 313
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OPENTitle: Large-scale replication and heterogeneity in Parkinson disease genetic lociJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 79Issue #: 7Start Page: 659End Page: 667Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318264e353Best OA location URL: https://n.neurology.org/content/neurology/79/7/659.full.pdfCitation Count: 128
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OPENTitle: Activity enhances dopaminergic long-duration response in Parkinson diseaseJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 78Issue #: 15Start Page: 1146End Page: 1149Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e31824f8056Best OA location URL: https://n.neurology.org/content/neurology/78/15/1146.full.pdfCitation Count: 28
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OPENTitle: Network correlates of disease severity in multiple system atrophyJournal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 78Issue #: 16Start Page: 1237End Page: 1244Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318250d7fdBest OA location URL: https://n.neurology.org/content/neurology/78/16/1237.full.pdfCitation Count: 56
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OPENTitle: Evidence-based guideline: Pharmacologic treatment of chorea in Huntington disease [RETIRED]Journal Name: NeurologyPublisher: Ovid Technologies (Wolters Kluwer Health)Vol: 79Issue #: 6Start Page: 597End Page: 603Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1212/wnl.0b013e318263c443Best OA location URL: https://n.neurology.org/content/neurology/79/6/597.full.pdfCitation Count: 159
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OPENTitle: Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γAgonist against MPTPJournal Name: PPAR ResearchPublisher: WileyVol: 2013Issue #:Start Page: 1End Page: 16Publication Date:Open Access(OA) Status: OPENLicense: cc-byDOI - Digital Object Identifier: 10.1155/2013/582809Best OA location URL: https://downloads.hindawi.com/journals/ppar/2013/582809.pdfCitation Count: 28
- Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a2003OPENTitle: Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5aJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 100Issue #: 22Start Page: 12747End Page: 12752Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1534900100Best OA location URL: http://doi.org/10.1073/pnas.1534900100Citation Count: 359
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OPENTitle: Neuroectodermal differentiation from mouse multipotent adult progenitor cellsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 100Issue #: suppl_1Start Page: 11854End Page: 11860Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1834196100Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/304098Citation Count: 356
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OPENTitle: Derivation of midbrain dopamine neurons from human embryonic stem cellsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 101Issue #: 34Start Page: 12543End Page: 12548Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0404700101Best OA location URL: http://doi.org/10.1073/pnas.0404700101Citation Count: 984
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OPENTitle: Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinson's diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 101Issue #: 50Start Page: 17510End Page: 17515Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0405313101Best OA location URL: http://doi.org/10.1073/pnas.0405313101Citation Count: 320
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OPENTitle: The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during agingJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 101Issue #: 26Start Page: 9843End Page: 9848Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0403495101Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/470762Citation Count: 461
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OPENTitle: Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stressJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 102Issue #: 14Start Page: 5215End Page: 5220Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0501282102Best OA location URL: http://doi.org/10.1073/pnas.0501282102Citation Count: 686
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OPENTitle: Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 103Issue #: 49Start Page: 18757End Page: 18762Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0606401103Best OA location URL: http://doi.org/10.1073/pnas.0606401103Citation Count: 164
- Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice2006OPENTitle: Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant miceJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 103Issue #: 41Start Page: 15242End Page: 15247Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0602116103Best OA location URL: http://doi.org/10.1073/pnas.0602116103Citation Count: 137
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OPENTitle: Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neuronsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 104Issue #: 4Start Page: 1325End Page: 1330Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0605208103Best OA location URL: http://doi.org/10.1073/pnas.0605208103Citation Count: 571
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OPENTitle: Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cellsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 104Issue #: 29Start Page: 12175End Page: 12180Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0704091104Best OA location URL: https://www.pnas.org/doi/pdf/10.1073/pnas.0704091104Citation Count: 347
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OPENTitle: Molecular markers of early Parkinson's disease based on gene expression in bloodJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 104Issue #: 3Start Page: 955End Page: 960Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0610204104Best OA location URL: http://doi.org/10.1073/pnas.0610204104Citation Count: 493
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OPENTitle: Physiology versus pathology in Parkinson's diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 104Issue #: 29Start Page: 11867End Page: 11868Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0704254104Best OA location URL: http://doi.org/10.1073/pnas.0704254104Citation Count: 11
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OPENTitle: Impaired dopamine release and synaptic plasticity in the striatum of PINK1 -deficient miceJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 104Issue #: 27Start Page: 11441End Page: 11446Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0702717104Best OA location URL: https://www.pnas.org/doi/pdf/10.1073/pnas.0702717104Citation Count: 522
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OPENTitle: Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTPJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 105Issue #: 5Start Page: 1716End Page: 1721Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0705363105Best OA location URL: http://doi.org/10.1073/pnas.0705363105Citation Count: 249
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OPENTitle: Murine models of acute neuronopathic Gaucher diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 104Issue #: 44Start Page: 17483End Page: 17488Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0708086104Citation Count: 188
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OPENTitle: GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synucleinJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 105Issue #: 31Start Page: 10907End Page: 10912Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0802437105Best OA location URL: https://www.pnas.org/content/pnas/105/31/10907.full.pdfCitation Count: 258
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OPENTitle: Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 104Issue #: 47Start Page: 18754End Page: 18759Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0704908104Best OA location URL: http://doi.org/10.1073/pnas.0704908104Citation Count: 416
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OPENTitle: Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegenerationJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 106Issue #: 33Start Page: 14063End Page: 14068Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0900096106Best OA location URL: http://doi.org/10.1073/pnas.0900096106Citation Count: 428
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OPENTitle: R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in miceJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 106Issue #: 34Start Page: 14622End Page: 14627Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0906334106Best OA location URL: http://doi.org/10.1073/pnas.0906334106Citation Count: 287
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OPENTitle: Targeting neural precursors in the adult brain rescues injured dopamine neuronsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 106Issue #: 32Start Page: 13570End Page: 13575Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0905125106Best OA location URL: https://europepmc.org/articles/pmc2714762?pdf=renderCitation Count: 95
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OPENTitle: Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neuronsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 106Issue #: 7Start Page: 2429End Page: 2434Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0810996106Best OA location URL: http://doi.org/10.1073/pnas.0810996106Citation Count: 141
- Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells2009OPENTitle: Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cellsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 106Issue #: 18Start Page: 7613End Page: 7618Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0902396106Best OA location URL: http://doi.org/10.1073/pnas.0902396106Citation Count: 219
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OPENTitle: In vivo demonstration that α-synuclein oligomers are toxicJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 108Issue #: 10Start Page: 4194End Page: 4199Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1100976108Best OA location URL: https://www.ncbi.nlm.nih.gov/pmc/articles/3053976Citation Count: 1395
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OPENTitle: Unexpected expression of α- and β-globin in mesencephalic dopaminergic neurons and glial cellsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 106Issue #: 36Start Page: 15454End Page: 15459Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.0813216106Best OA location URL: http://www.pnas.org/content/106/36/15454.full.pdfCitation Count: 256
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OPENTitle: Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged miceJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 107Issue #: 21Start Page: 9879End Page: 9884Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1004676107Best OA location URL: http://doi.org/10.1073/pnas.1004676107Citation Count: 488
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OPENTitle: Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomasJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 108Issue #: 4Start Page: 1439End Page: 1444Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1012500108Citation Count: 88
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OPENTitle: Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson diseaseJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 109Issue #: 39Start Page: 15918End Page: 15923Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1205102109Best OA location URL: https://www.pnas.org/content/pnas/109/39/15918.full.pdfCitation Count: 87
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OPENTitle: Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutationsJournal Name: Proceedings of the National Academy of SciencesPublisher: Proceedings of the National Academy of SciencesVol: 109Issue #: 26Start Page: 10322End Page: 10327Publication Date:Open Access(OA) Status: OPENLicense:DOI - Digital Object Identifier: 10.1073/pnas.1203223109Best OA location URL: https://www.pnas.org/content/pnas/109/26/10322.full.pdfCitation Count: 97