… Degenerative disease of the central nervous system, such as Alzheimer's and Parkinson's disease, are … proteins through an active cellular garbage collection system called the proteasome. In pathological situations … studies have increasingly suggested that this scavenging system is impaired and can lead to an accumulation of …

… The complement system is composed of a series of proteins which react with … removal of microorganisms and tissue debris by the immune system, but excessive activation of this system can result in cellular injury; inappropriate …

… controlled with medications acting on the dopaminergic system or with deep brain stimulation. Indirect evidence … will be the most direct test of the role of cholinergic systems in gait and balance. Hypothesis: We hypothesize that cholinergic systems contribute to mobility such that measures of gait, …

… The development of high efficiency, central nervous system (CNS) targeting AAV-based gene therapies is necessary … AAV9, but with variable effect depending on animal system, strain, and delivery route. As most … of intracisternal infusions of AAV.PHP.eB as an optimal system to distribute CNS gene therapies in preclinical …

… between immune cells in the peripheral and central nervous systems in age-related neurodegenerative disorders such as … provide therapeutic targets to treat the impaired immune system in Parkinson’s. She obtained her doctorate in …

… that guide strategy management, planning, and control of multiple projects. Enrich decision making around key … Manage competing resources and priorities across multiple teams • Incorporate measurement strategies to … organize and structure work • Ability to multitask across multiple projects under tight timelines and complex …