… controlled with medications acting on the dopaminergic system or with deep brain stimulation. Indirect evidence … will be the most direct test of the role of cholinergic systems in gait and balance. Hypothesis: We hypothesize that cholinergic systems contribute to mobility such that measures of gait, …

… The development of high efficiency, central nervous system (CNS) targeting AAV-based gene therapies is necessary … AAV9, but with variable effect depending on animal system, strain, and delivery route. As most … of intracisternal infusions of AAV.PHP.eB as an optimal system to distribute CNS gene therapies in preclinical …

… peptide receptor 2 (VPAC2), which affects the immune system by turning neurotoxic (causes nervous system damage) activities to neurotrophic (promotes nervous system growth) activities. Here, we aim to explore …

… on immune cells found in both the peripheral nervous system and the brain. The peripheral nervous system includes all of the nerves that branch out from the … between immune cells in the central and peripheral nervous systems to alter the alpha-synuclein-induced inflammatory …

… candidates that could cause inflammation in the nervous system. One likely candidate involves the activity of … this activity can induce inflammation in the nervous system. Study Design: We will first look for evidence of … signs of inflammation. Because cells of the central nervous system (neurons, astrocytes and microglia) can be grown in a …

… for detecting gait freezing episodes and develop a system for applying stimulation parameters tailored to … develop and make available a deep brain stimulation (DBS) system that automatically detects gait freezing episodes and … stimulation to minimize freezing episodes using a novel DBS system that allows for chronic brain recording. The safety …