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Pre-Clinical Models of Parkinson's Disease
… an internal control and the adaptability of this model for multiple species. Disadvantage: Use of supraphysiological … to area of injection while pathology in PD often occurs in multiple brain regions and peripheral tissues Virus can … lesion with a protracted time course Pathology in multiple brain regions relevant for PD Good for studies …
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Hao Wu, PhD
… Dr. Wu focuses on studying how components of the immune system assemble and communicate. Dr. Wu’s laboratory focuses … development for diseases that involve the immune system, including cardiovascular, neurodegenerative and …
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Role of GBA in Mitochondrial Antigen Presentation
… neurons in the brain. We propose that the immune system plays a key role in the death of dopaminergic neurons … PD via a mechanism called autoimmunity, when the immune system starts to attack our own cells. The lysosome, a small … and autoimmunity will allow us to target the immune system for the development of novel therapeutic approaches. …
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Analysis of the ENS Using Routine Colonic Biopsies as a Biomarker for PD: Optimizing Detection of Alpha-Synuclein Pathology and Assessment in LRRK2 Patients
… from a prior grant: Analysis of the Enteric Nervous System Using Routine Colonic Biopsies: A Biomarker of … funded by MJFF, we have shown that the enteric nervous system was readily analyzed using routine colonic biopsies … larger scale surveys; second, to study the enteric nervous system (ENS) using colonic biopsies in patients with a …
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eWeek Profiles Digital Innovation from The Michael J. Fox Foundation
April 26, 2012
… the usability of the tool, “ Users can search the matching system without creating a profile by answering three … stage of diagnosis. A key to the three-question matching system is its simplicity.” Read more on Fox Trial Finder …
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Peter Vangheluwe, PhD
… and since 2012 has led the Laboratory of Cellular Transport Systems. His research focuses on lysosomal transport systems that are implicated in Parkinson’s disease (PD) in …