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Cytokine Production by Adaptive Immune Cells in Parkinson’s Disease: Response to Diverse Biological Stimuli
… Many studies indicate a role for the adaptive immune system in Parkinson’s disease. Our study will produce … that may cause inflammation and degeneration of the nervous system. Cytokines are crucial in controlling the growth and activity of other immune system cells and blood cells, and these differences could be …
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Activation of Transposable Elements as a Trigger of Neuroinflammation in Parkinson’s Disease
… factors can potentially trigger inflammation in the nervous system. One possible candidate is the activation of … that this activity can induce inflammation in the nervous system and contribute to PD pathology. Study Design: We … signs of inflammation. Because cells of the central nervous system (neurons, astrocytes and microglia) can be grown in …
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Ann Marie Janson Lang, MD, PhD
… actions of nicotine on lesioned nigrostriatal dopamine systems’. After seeing her first parkinsonian patients and … a research team working on injury and repair of the nervous system. Her expertise in Quantitative Neuroscience … or repair the partially injured nigrostriatal dopamine system. Janson Lang serves in the board of the Swedish …
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Characterizing NOD2 Genetic Landscape Driving Risk of Parkinson’s Disease
… The NOD2 protein plays a key role in how the immune system detects bacteria and protects the gut. Recent … By exploring the role of NOD2 in the brain, gut and immune system, we hope to uncover new clues about what causes PD … the risk of PD by altering gene expression and immune system activity in the brain and body. Study Design: We will …
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An AMP-PD Resource of Allele Calls for Polymorphic Determinants of Immune Function
… Study Rationale: The immune system plays a complex role in Parkinson’s disease (PD), … is often inaccurate. To fully understand how the immune system affects PD, researchers need a precise method to … participants, revealing connections between the immune system and the disease that prior, less accurate standard …
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Real-time Monitoring of Targeting, Delivery and Spread of Therapeutic Agents in the Brain
… (OCT) imaging. OCT is a real-time optical imaging system that produces high-resolution images of the brain. It … Outcome: The most important outcome will be to provide a system that gives real time intraoperative feedback on … research team has integrated the OCT probe with a delivery system that allows the delivery of viral vectors to targets …