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Determining the Role of Proteins Associated with Parkinson’s Disease in T cell-Mediated Destruction of Dopamine Neurons
… proteins associated with PD significantly impact the immune system, suggesting that PD might be an autoimmune disease. … initiated by inherited or age-related defects in the immune system whereby infections drive production of autoimmune T … pave the way for early treatments targeting the immune system, potentially preventing PD. The identification of a …
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Development of Biochemical Assays for LRRK1
… biochemical assays for LRRK1. Project Description : Multiple approaches will be taken to both produce active, …
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Validation of CD4 T Cell Dependent Neurotoxicity in an Alpha-Synuclein Model of Parkinson's Disease
… their way through clinical trials for disorders including multiple sclerosis. It is important to assess whether …
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Current and projected future economic burden of Parkinson's disease in the U.S
June 2, 2020
… the U.S. (2017) and projections for the next two decades. Multiple data sources were used to estimate the costs of PD, …
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Plasma-borne indicators of inflammasome activity in Parkinson’s disease patients
November 13, 2020
… PD patient plasma for evidence of inflammasome activity. Multiple circulating inflammasome proteins were detected …
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Validation of RRx-001 as a Novel Disease-modifying Therapeutic for Parkinson's Disease
… Study Design: We will test the effectiveness of RRx-001 in multiple pre-clinical models of Parkinson’s disease and also …