… lie in the development and physiology of the nervous system, with a special focus on homeogenes and homeoprotein … CNRS Research Unit Development and Evolution of the Nervous System at Ecole Normale Supérieure and member of the French …

… My brain research program has a central theme of integrated systems biology in which molecular mechanisms associated … drug abuse and degenerative diseases of the central nervous system are studied. The ultimate goal of these studies is to …

… of transmembrane receptors, the role of the ubiquitin system in protein regulation, and in development of … to manipulate specific components of the ubiquitin system as a basis for therapeutics. Dr. Weissman has been …

… abnormal cellular proteins via the ubiquitin-proteasome system. It has been hypothesized that parkin is important in … is to be tested, it is crucial that the experimental system allows for the examination of what happens when …

… of a separate, relatively autonomous, ‘enteric nervous system’ (ENS) located in the stomach and intestines that … treatments with a higher likelihood of success. An animal system that mimics parkinsonian GI dysfunction would provide … and was associated with dysfunction in the enteric nervous system. This has provided an animal model for delayed …

… the MPTP-induced degenerative process in the nigrostriatal system will be assessed. Relevance to Diagnosis/Treatment of … expression of alpha synuclein in the nigrostriatal system. If successful, this can be applied to other regions … delivery of microRNA’s 7 and 153 protect the nigrostriatal system from MPTP toxicity.   …