… a protein that protects axons in the peripheral nervous system can similarly protect axons in the brain.  We first … benefit. Then we examined the integrity of the dopamine system. The neurturin conferred protection of the dopamine … NMAT did not confer protection of the axons in the dopamine system. …

… will test the toxicity of these mutants in an experimental system by investigating dopaminergic loss in the substantia … The dual approach (in vitro characterization in a cell free system and the in vivo approach) will allow us to correlate … we tested the toxicity of these mutants in an experimental system by investigating dopaminergic loss in the substantia …

… Project Description:  The study aims to develop a Web-based system to monitor subjects in their homes with miniature … measure the severity of Parkinson’s symptoms. The Web-based system will provide videoconferencing capability, access to … Outcome: The project will provide the first Web-based system to remotely access sensor data recorded from …

… influenced by both sympathetic and parasympathetic nervous system and is thus a reliable method of studying the autonomic nervous system. Several time and frequency domain parameters will be … it will indicate that changes in the peripheral nervous system are an early pre-motor feature of PD and may provide …

… complicated than “good” or “bad.” It has important immune system functions, such as fighting off infection. But when … they hamper both chronic inflammation and beneficial immune system functions. However, another immune system target, called inflammasomes, may be the key to …

… of toxic alpha-synuclein spread throughout the nervous system. His group also develops therapeutic strategies for …