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Alkahest Begins Phase II Trial of Plasma-Based Therapy
December 7, 2018
… an IV infusion. Alkahest is recruiting volunteers at multiple sites, who have Parkinson's disease and cognitive …
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Characterization of a humanized A53T alpha-synuclein (aSyn A53T KI) and alpha-synuclein KO (aSyn KO) models
October 20, 2019
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Genome-wide Association Study in Parkinson’s Disease Among an East Asian Population
… have lacked sufficient sample size. We would like to pull multiple Asian centers together and run a genome-wide …
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Effects of Post-translational Modifications on Alpha-synuclein Aggregation
… Study Design: Alpha-synuclein variants with individual or multiple post-translational modifications will be generated …
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Chaperones of Alpha-synuclein for Membrane Fusion Involved in Synaptic Transmission
… these aims, we will use cell-free preparations and multiple biophysical, biochemical and molecular assays, …
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Analysis and Amplification of Pathological Alpha-synuclein from Brain Tissue
… study is to solve these technical challenges and to systematically analyze the properties of misfolded … purified misfolded alpha-synuclein from patients and to systematically study the properties of misfolded alpha-synuclein in Parkinson’s brains using multiple models. Moreover, we also propose to establish a …