… We recently demonstrated that strong immune system stimulation created by treating pre-clinical models … can have a restorative effect on nigrostriatal dopamine system integrity and limit potentially deleterious …

… have provided the field with tools that can be used to systematically investigate roles for LRRK2 during neuronal … neurons grown in culture have served as an excellent model system in which to evaluate neural differentiation. The pre-clinical and culture model systems together will permit us to determine definitively …

… not only affect movement but also the autonomic nervous system. Since most people start developing the disease in … diseases with involvement of the autonomic nervous system. While this process will begin in the participating …

… tract -- influences the development of the nervous system, affects behavior and contributes to various disorders of the nervous system. Because non-genetic factors appear to play a role in …

… on alpha-synuclein folding. We are studying a simplified system in which sphingolipid can be maintained at more … sources could be undertaken using the current experimental system in order to identify compounds that would prevent …

… the brain stem as the first region in the central nervous system to be affected by alpha-synuclein aggregation. Since DMX is an integral part of the autonomic nervous system, it is postulated that damage to this brain region …